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Gene Review

Guca1a  -  guanylate cyclase activator 1a (retina)

Mus musculus

Synonyms: GC-A, GCAP 1, Gcap, Gcap1, Guanylate cyclase activator 1A, ...
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Disease relevance of Guca1a


High impact information on Guca1a

  • This feedback loop was disrupted in mouse rods lacking guanylate cyclase activating proteins GCAP1 and GCAP2 (GCAPs(-/-)) [2].
  • Ca(2+) regulates the activity of guanylate cyclase (GC) and the synthesis of cGMP by acting on a GC-activating protein (GCAP) [3].
  • In this communication, we explored the role of GCAP1 in cone photoreceptors by using electroretinograms (ERGs) [4].
  • Guanylate cyclase-activating protein (GCAP) 1 rescues cone recovery kinetics in GCAP1/GCAP2 knockout mice [4].
  • When GCAP1 is expressed in transgenic mice on a GCAP null background, it restores the wild-type flash responses in rod photoreceptors [4].

Biological context of Guca1a


Anatomical context of Guca1a

  • To investigate the extent of this phenomenon we examined additional photoreceptor proteins that might undergo light-driven translocation, focusing on three Ca(2+)-binding proteins, recoverin and guanylate cyclase activating proteins 1 (GCAP1) and GCAP2 [7].
  • Mastoparan potently stimulated catalytic activity of guanylate cyclase-coupled atrial natriuretic factor receptor (GC-A/ANF-R), both in the plasma membranes and intact Leydig tumor (MA-10) cells [8].

Associations of Guca1a with chemical compounds

  • The data establish a role for mastoparan in the ANF-dependent stimulation of GC-A/ANF-R catalytic activity, both in the plasma membrane preparations and intact Leydig tumor (MA-10) cells [8].

Other interactions of Guca1a

  • To the contrary, no translocation of rhodopsin kinase itself or either GCAP was identified [7].

Analytical, diagnostic and therapeutic context of Guca1a


  1. Mouse models to study GCAP functions in intact photoreceptors. Mendez, A., Chen, J. Adv. Exp. Med. Biol. (2002) [Pubmed]
  2. Dynamics of cyclic GMP synthesis in retinal rods. Burns, M.E., Mendez, A., Chen, J., Baylor, D.A. Neuron (2002) [Pubmed]
  3. GCAP1 rescues rod photoreceptor response in GCAP1/GCAP2 knockout mice. Howes, K.A., Pennesi, M.E., Sokal, I., Church-Kopish, J., Schmidt, B., Margolis, D., Frederick, J.M., Rieke, F., Palczewski, K., Wu, S.M., Detwiler, P.B., Baehr, W. EMBO J. (2002) [Pubmed]
  4. Guanylate cyclase-activating protein (GCAP) 1 rescues cone recovery kinetics in GCAP1/GCAP2 knockout mice. Pennesi, M.E., Howes, K.A., Baehr, W., Wu, S.M. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  5. Molecular characterization of human and mouse photoreceptor guanylate cyclase-activating protein (GCAP) and chromosomal localization of the human gene. Subbaraya, I., Ruiz, C.C., Helekar, B.S., Zhao, X., Gorczyca, W.A., Pettenati, M.J., Rao, P.N., Palczewski, K., Baehr, W. J. Biol. Chem. (1994) [Pubmed]
  6. Gene array and expression of mouse retina guanylate cyclase activating proteins 1 and 2. Howes, K., Bronson, J.D., Dang, Y.L., Li, N., Zhang, K., Ruiz, C., Helekar, B., Lee, M., Subbaraya, I., Kolb, H., Chen, J., Baehr, W. Invest. Ophthalmol. Vis. Sci. (1998) [Pubmed]
  7. Recoverin undergoes light-dependent intracellular translocation in rod photoreceptors. Strissel, K.J., Lishko, P.V., Trieu, L.H., Kennedy, M.J., Hurley, J.B., Arshavsky, V.Y. J. Biol. Chem. (2005) [Pubmed]
  8. Modulation of guanylate cyclase-coupled atrial natriuretic factor receptor activity by mastoparan and ANF in murine Leydig tumor cells: role of G-proteins. Khurana, M.L., Pandey, K.N. Biochim. Biophys. Acta (1994) [Pubmed]
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