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MeSH Review

Heart-Lung Machine

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Disease relevance of Heart-Lung Machine


Psychiatry related information on Heart-Lung Machine


High impact information on Heart-Lung Machine

  • Administration of a kallikrein-trypsin inhibitor, trasylol (A. G. Bayer), infused into the heart-lung machine, prevented the decrease of kininogen [3].
  • This difference was -139.04 in on-pump cases and -90.51 in off-pump cases, primarily a function of the fact that higher heparin doses and therefore longer ACTs were used in patients having operations using the heart-lung machine [4].
  • As an alternative, intraaortic infusion of potassium chloride through the arterial line from the heart-lung machine was investigated [1].
  • In an in vitro setting with a heart-lung machine primed with fresh whole blood and saline solution, the C3 activation products C3b, iC3b, and C3c and the terminal complement complex were measured in double-antibody enzyme immunosorbent assays [5].
  • Group II (10 patients) received 75% of the calculated protamine dose within 10 minutes after termination of bypass and the remainder after transfusion of all blood in the heart-lung machine [6].

Biological context of Heart-Lung Machine

  • Hydroxyethyl starch was used as the exclusive artificial colloid for acute normovolemic hemodilution, priming of the heart lung machine, and for intra- and postoperative plasma volume substitution from induction of anesthesia until 16 hr after the end of surgery [7].
  • One hundred and four individuals representing a cross-section of the United States who function as operators of heart-lung machines during open heart surgery (perfusionists) were studied using both internal and external models based on the works of Eric Berne and Karen Horney [8].

Associations of Heart-Lung Machine with chemical compounds

  • The increase in prostaglandin E2 was influenced by the heart-lung machine itself (as demonstrated by a closed "bypass" circuit) and by lung bypass [9].
  • Curves relating left ventricular end-diastolic pressure (EDP) to echocardiographically determined end-diastolic diameter (EDD) were determined during the transfusion of volume from the reservoir of the heart-lung machine (EDP varied from 5 to 35 mm Hg) before and during nitroprusside administration (1 to 4 mcg/kg/min) [10].
  • Phospholipase A activity was determined in human plasma with biological 32P-labelled phosphatidylethanolamine from rat liver following cardiac operations with the aid of the heart-lung-machine [11].
  • Pentoxifylline was initially administered in the prime of the heart-lung machine in coronary patients and intra-arterially in peripheral vascular patients [12].
  • A Tribute to Frank F Alibritten, Jr. Origin of the left ventricular vent during the early years of open-heart surgery with the Gibbon heart-lung machine [13].

Gene context of Heart-Lung Machine


  1. Conversion of postischemic ventricular fibrillation with intraaortic infusion of potassium chloride. Ovrum, E., Tangen, G., Holen, E.A., Ringdal, M.A., Istad, R. Ann. Thorac. Surg. (1995) [Pubmed]
  2. Lorazepam in open-heart surgery--plasma concentrations before, during and after bypass following different dose regimens. Boscoe, M.J., Dawling, S., Thompson, M.A., Jones, R.M. Anaesthesia and intensive care. (1984) [Pubmed]
  3. Inhibition of kinin formation by a kallikrein inhibitor during extracorporeal circulation in open-heart surgery. Nagaoka, H., Katori, M. Circulation (1975) [Pubmed]
  4. New technology, old standards: disparate activated clotting time measurements by the Hemochron Jr compared with the standard Hemochron. Aylsworth, C.L., Stefan, F., Woitas, K., Rieger, R.H., LeBoutillier, M., DiSesa, V.J. Ann. Thorac. Surg. (2004) [Pubmed]
  5. Complement activation during extracorporeal circulation. In vitro comparison of Duraflo II heparin-coated and uncoated oxygenator circuits. Svennevig, J.L., Geiran, O.R., Karlsen, H., Pedersen, T., Mollnes, T.E., Kongsgard, U., Frøysaker, T. J. Thorac. Cardiovasc. Surg. (1993) [Pubmed]
  6. Comparison of two protocols for heparin neutralization by protamine after cardiopulmonary bypass. Arén, C., Feddersen, K., Rådegran, K. J. Thorac. Cardiovasc. Surg. (1987) [Pubmed]
  7. A novel hydroxyethyl starch (Voluven) for effective perioperative plasma volume substitution in cardiac surgery. Gallandat Huet, R.C., Siemons, A.W., Baus, D., van Rooyen-Butijn, W.T., Haagenaars, J.A., van Oeveren, W., Bepperling, F. Canadian journal of anaesthesia = Journal canadien d'anesthésie. (2000) [Pubmed]
  8. The cardiovascular perfusionist as a model for the successful technologist in high stress situations. Friday, P.J., Mook, W.J. The Journal of the Society of Occupational Medicine. (1991) [Pubmed]
  9. Prostaglandin E2, prostacyclin, and thromboxane changes during nonpulsatile cardiopulmonary bypass in humans. Faymonville, M.E., Deby-Dupont, G., Larbuisson, R., Deby, C., Bodson, L., Limet, R., Lamy, M. J. Thorac. Cardiovasc. Surg. (1986) [Pubmed]
  10. Effect of nitroprusside on end-diastolic pressure-diameter relations of the human left ventricle after pericardiotomy. Wong, C.Y., Spotnitz, H.M. J. Thorac. Cardiovasc. Surg. (1981) [Pubmed]
  11. Some examples of the clinical importance of the basic and heparin-induced phospholipase A in human plasma. Olthoff, D., Rüstow, B., Kunze, D. Clin. Chim. Acta (1982) [Pubmed]
  12. Can aortocoronary and peripheral venous bypass graft patency be improved by the administration of pentoxifylline on a long-term basis? Angelides, N.S., Minas, C. Cardiologia (Rome, Italy) (1999) [Pubmed]
  13. A Tribute to Frank F Alibritten, Jr. Origin of the left ventricular vent during the early years of open-heart surgery with the Gibbon heart-lung machine. Hedlund, K.D. Texas Heart Institute journal / from the Texas Heart Institute of St. Luke's Episcopal Hospital, Texas Children's Hospital. (2001) [Pubmed]
  14. John H. Gibbon, Jr. Part I. The development of the first successful heart-lung machine. Hill, J.D. Ann. Thorac. Surg. (1982) [Pubmed]
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