- Epithelial toll-like receptor 5 is constitutively localized in the mouse cecum and exhibits distinctive down-regulation during experimental colitis. Ortega-Cava, C.F., Ishihara, S., Rumi, M.A., Aziz, M.M., Kazumori, H., Yuki, T., Mishima, Y., Moriyama, I., Kadota, C., Oshima, N., Amano, Y., Kadowaki, Y., Ishimura, N., Kinoshita, Y. Clinical and vaccine immunology : CVI. (2006)