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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Immunohistochemical demonstration of choline acetyltransferase-immunoreactive preganglionic nerve fibers in guinea pig autonomic ganglia.

The distribution of choline acetyltransferase (ChoAcTase)-like immunoreactivity in the superior cervical ganglion and the stellate ganglion was analyzed with immunohistochemistry. A dense network of ChoAcTase-immunoreactive nerve fibers was observed in both ganglia studied. The ChoAcTase-positive fibers were found in all parts of the ganglia but had a differential distribution, giving rise to a patchy staining pattern. After preganglionic denervation of the superior cervical ganglia, all ChoAcTase-positive fibers disappeared. For comparison, the distributions of enkephalin- and neuropeptide Y-like immunoreactivity were analyzed. In the stellate ganglion, the enkephalin-positive fibers had a marked regional distribution. Areas with the highest enkephalin-fiber density seemed to contain low numbers of ChoAcTase-positive fibers and vice versa. The findings give evidence for occurrence of acetylcholine synthesis in preganglionic fibers in paravertebral sympathetic ganglia.[1]

References

  1. Immunohistochemical demonstration of choline acetyltransferase-immunoreactive preganglionic nerve fibers in guinea pig autonomic ganglia. Lindh, B., Staines, W., Hökfelt, T., Terenius, L., Salvaterra, P.M. Proc. Natl. Acad. Sci. U.S.A. (1986) [Pubmed]
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