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Gene Review

CHAT  -  choline O-acetyltransferase

Sus scrofa

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Disease relevance of CHAT


Psychiatry related information on CHAT


High impact information on CHAT


Chemical compound and disease context of CHAT


Biological context of CHAT


Anatomical context of CHAT


Associations of CHAT with chemical compounds

  • The enzyme choline acetyltransferase catalyses the biosynthesis of the neurotransmitter acetylcholine and constitutes a specific marker of cholinergic system [16].
  • The absence of significant changes in the total amount of the neuronal enzyme, choline acetyltransferase, per ventricle contrasted with the observed increases in the myocardial enzyme, carnitine acetyltransferase [1].
  • Diaminobenzidine and tetramethylbenzidine were used as chromogens to distinguish ChAT (protein) and VIP (peptide) immunoreactivities [20].
  • PPPFL fixative is more reliable for simultaneously preserving ChAT and VIP immunoreactivities than were periodate-lysine-paraformaldehyde (PLP) fixative, Zamboni's fixative, or 2% paraformaldehyde solution alone [20].
  • ChAT was measured by the synthesis of 3H-acetylcholine in the presence of 3H-acetyl CoA and choline [17].

Co-localisations of CHAT


Other interactions of CHAT


Analytical, diagnostic and therapeutic context of CHAT


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  10. cDNA cloning, sequence analysis, and chromosomal localization of the gene for human carnitine palmitoyltransferase. Finocchiaro, G., Taroni, F., Rocchi, M., Martin, A.L., Colombo, I., Tarelli, G.T., DiDonato, S. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
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  12. Nitric oxide synthase, choline acetyltransferase, catecholamine enzymes and neuropeptides and their colocalization in the anterior pelvic ganglion, the inferior mesenteric ganglion and the hypogastric nerve of the male guinea pig. Elfvin, L.G., Holmberg, K., Emson, P., Schemann, M., Hökfelt, T. J. Chem. Neuroanat. (1997) [Pubmed]
  13. Effect of total or partial uterus extirpation on uterus-projecting neurons in porcine inferior mesenteric ganglion. A. Changes in expression of transmitter-synthesizing enzymes--tyrosine hydroxylase, dopamine beta-hydroxylase and choline acetyltransferase. Wasowicz, K. Polish journal of veterinary sciences. (2003) [Pubmed]
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  17. Biochemical evidence for cholinergic activity in retinal blood vessels. Ferrari-Dileo, G., Davis, E.B., Anderson, D.R. Invest. Ophthalmol. Vis. Sci. (1989) [Pubmed]
  18. Distinct contributions of high- and low-voltage-activated calcium currents to afterhyperpolarizations in cholinergic nucleus basalis neurons of the guinea pig. Williams, S., Serafin, M., Mühlethaler, M., Bernheim, L. J. Neurosci. (1997) [Pubmed]
  19. Nerve growth factor-mediated induction of choline acetyltransferase in PC12 cells: evaluation of the site of action of nerve growth factor and the involvement of lysosomal degradation products of nerve growth factor. Heumann, R., Schwab, M., Merkl, R., Thoenen, H. J. Neurosci. (1984) [Pubmed]
  20. Cholinergic and VIPergic innervation in cerebral arteries: a sequential double-labeling immunohistochemical study. Miao, F.J., Lee, T.J. J. Cereb. Blood Flow Metab. (1990) [Pubmed]
  21. Localization of dynorphin B-like and alpha-neoendorphin-like immunoreactivities in the guinea pig organ of Corti. Altschuler, R.A., Hoffman, D.W., Reeks, K.A., Fex, J. Hear. Res. (1985) [Pubmed]
  22. Action of bradykinin in the submucosal plexus of guinea pig small intestine. Hu, H.Z., Gao, N., Liu, S., Ren, J., Wang, X., Xia, Y., Wood, J.D. J. Pharmacol. Exp. Ther. (2004) [Pubmed]
  23. Heterogeneous expression of SNAP-25 and synaptic vesicle proteins by central and peripheral inputs to sympathetic neurons. Gibbins, I.L., Jobling, P., Teo, E.H., Matthew, S.E., Morris, J.L. J. Comp. Neurol. (2003) [Pubmed]
  24. Muscular innervation of the proximal duodenum of the guinea pig. Iino, S. Arch. Histol. Cytol. (2000) [Pubmed]
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  26. Choline acetyltransferase-containing neurons in rodent brain demonstrated by immunohistochemistry. Kimura, H., McGeer, P.L., Peng, F., McGeer, E.G. Science (1980) [Pubmed]
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  28. Inputs from intrinsic primary afferent neurons to nitric oxide synthase-immunoreactive neurons in the myenteric plexus of guinea pig ileum. Li, Z.S., Furness, J.B. Cell Tissue Res. (2000) [Pubmed]
  29. Preganglionic sympathetic neurones, innervating the guinea pig adrenal medulla, immunohistochemically contain choline acetyltransferase and also leu-enkephalin. Colombo-Benkmann, M., Heym, C., Schemann, M. Neurosci. Lett. (1995) [Pubmed]
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