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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Human thrombopoietin: gene structure, cDNA sequence, expression, and chromosomal localization.

Thrombopoietin ( TPO), a lineage-specific cytokine affecting the proliferation and maturation of megakaryocytes from committed progenitor cells, is believed to be the major physiological regulator of circulating platelet levels. Recently we have isolated a cDNA encoding a ligand for the murine c-mpl protooncogene and shown it to be TPO. By employing a murine cDNA probe, we have isolated a gene encoding human TPO from a human genomic library. The TPO locus spans over 6 kb and has a structure similar to that of the erythropoietin gene ( EPO). Southern blot analysis of human genomic DNA reveals a hybridization pattern consistent with a single gene locus. The locus was mapped by in situ hybridization of metaphase chromosome preparations to chromosome 3q26-27, a site where a number of chromosomal abnormalities associated with thrombocythemia in cases of acute myeloid leukemia have been mapped. A human TPO cDNA was isolated by PCR from kidney mRNA. The cDNA encodes a protein with 80% identity to previously described murine TPO and is capable of initiating a proliferative signal to murine interleukin 3-dependent BaF3 cells expressing the murine or human TPO receptor.[1]


  1. Human thrombopoietin: gene structure, cDNA sequence, expression, and chromosomal localization. Foster, D.C., Sprecher, C.A., Grant, F.J., Kramer, J.M., Kuijper, J.L., Holly, R.D., Whitmore, T.E., Heipel, M.D., Bell, L.A., Ching, A.F. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
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