Gene Review:
MPL - MPL proto-oncogene, thrombopoietin receptor
Homo sapiens
Synonyms:
C-MPL, CD110, MPLV, Myeloproliferative leukemia protein, Proto-oncogene c-Mpl, ...
- MPLW515L Is a Novel Somatic Activating Mutation in Myelofibrosis with Myeloid Metaplasia. Pikman, Y., Lee, B.H., Mercher, T., McDowell, E., Ebert, B.L., Gozo, M., Cuker, A., Wernig, G., Moore, S., Galinsky, I., Deangelo, D.J., Clark, J.J., Lee, S.J., Golub, T.R., Wadleigh, M., Gilliland, D.G., Levine, R.L. PLoS Med. (2006)
- Molecular cloning and characterization of MPL, the human homolog of the v-mpl oncogene: identification of a member of the hematopoietic growth factor receptor superfamily. Vigon, I., Mornon, J.P., Cocault, L., Mitjavila, M.T., Tambourin, P., Gisselbrecht, S., Souyri, M. Proc. Natl. Acad. Sci. U.S.A. (1992)
- Familial essential thrombocythemia associated with a dominant-positive activating mutation of the c-MPL gene, which encodes for the receptor for thrombopoietin. Ding, J., Komatsu, H., Wakita, A., Kato-Uranishi, M., Ito, M., Satoh, A., Tsuboi, K., Nitta, M., Miyazaki, H., Iida, S., Ueda, R. Blood (2004)
- A putative truncated cytokine receptor gene transduced by the myeloproliferative leukemia virus immortalizes hematopoietic progenitors. Souyri, M., Vigon, I., Penciolelli, J.F., Heard, J.M., Tambourin, P., Wendling, F. Cell (1990)
- Use of adjuvant containing mycobacterial cell-wall skeleton, monophosphoryl lipid A, and squalane in malaria circumsporozoite protein vaccine. Rickman, L.S., Gordon, D.M., Wistar, R., Krzych, U., Gross, M., Hollingdale, M.R., Egan, J.E., Chulay, J.D., Hoffman, S.L. Lancet (1991)
- Advances in vaccine adjuvants. Singh, M., O'Hagan, D. Nat. Biotechnol. (1999)
- Differential staining of Western blots of human secreted glycoproteins from serum, milk, saliva, and seminal fluid using lectins displaying diverse sugar specificities. Gilboa-Garber, N., Lerrer, B., Lesman-Movshovich, E., Dgani, O. Electrophoresis (2005)
- Enhanced immunogenicity of a recombinant genital warts vaccine adjuvanted with monophosphoryl lipid A. Thompson, H.S., Davies, M.L., Watts, M.J., Mann, A.E., Holding, F.P., O'Neill, T., Beech, J.T., Thompson, S.J., Leesman, G.D., Ulrich, J.T. Vaccine (1998)
- Neuropsychiatric systemic lupus erythematosus presenting as amyotrophic lateral sclerosis. Maldonado, M.E., Williams, R.C., Adair, J.C., Hart, B.L., Gregg, L., Sibbitt, W.L. J. Rheumatol. (2002)
- Enhancement of antigen-specific immunity via the TLR4 ligands MPL adjuvant and Ribi.529. Evans, J.T., Cluff, C.W., Johnson, D.A., Lacy, M.J., Persing, D.H., Baldridge, J.R. Expert review of vaccines. (2003)
- Low Mpl receptor expression in a pedigree with familial platelet disorder with predisposition to acute myelogenous leukemia and a novel AML1 mutation. Heller, P.G., Glembotsky, A.C., Gandhi, M.J., Cummings, C.L., Pirola, C.J., Marta, R.F., Kornblihtt, L.I., Drachman, J.G., Molinas, F.C. Blood (2005)
- A novel MPL point mutation resulting in thrombopoietin-independent activation. Abe, M., Suzuki, K., Inagaki, O., Sassa, S., Shikama, H. Leukemia (2002)
- The human homolog of the myeloproliferative virus maps to chromosome band 1p34. Le Coniat, M., Souyri, M., Vigon, I., Wendling, F., Tambourin, P., Berger, R. Hum. Genet. (1989)
- Association of single nucleotide polymorphisms in the thrombopoietin-receptor gene, but not the thrombopoietin gene, with differences in platelet count. Zeng, S.M., Murray, J.C., Widness, J.A., Strauss, R.G., Yankowitz, J. Am. J. Hematol. (2004)
- Thrombocytosis in preterm infants: a possible involvement of thrombopoietin receptor gene expression. Nakayama, H., Ihara, K., Hikino, S., Yamamoto, J., Nagatomo, T., Takemoto, M., Hara, T. J. Mol. Med. (2005)
- Hereditary thrombocythaemia is a genetically heterogeneous disorder: exclusion of TPO and MPL in two families with hereditary thrombocythaemia. Wiestner, A., Padosch, S.A., Ghilardi, N., Cesar, J.M., Odriozola, J., Shapiro, A., Skoda, R.C. Br. J. Haematol. (2000)
- Expression of thrombopoietin and thrombopoietin receptor MPL in human leukemia-lymphoma and solid tumor cell lines. Graf, G., Dehmel, U., Drexler, H.G. Leuk. Res. (1996)
- Expression of c-Mpl and c-Mpl ligand gene in hematopoietic cells of individuals with and without myeloproliferative disorders and leukemia cell lines. Sasaki, A., Katoh, O., Kawaishi, K., Hyodo, H., Kimura, A., Satow, Y., Kuramoto, A. Int. J. Hematol. (1995)
- Cytosolic Ca(2+) levels and DNA synthesis of human umbilical vein endothelial cell cultures are unresponsive to thrombopoietin treatment. Metzen, E., Giesen, G., Fandrey, J., Jelkmann, W. Cell. Physiol. Biochem. (2001)
- Enhanced humoral and memory B cellular immunity using HPV16/18 L1 VLP vaccine formulated with the MPL/aluminium salt combination (AS04) compared to aluminium salt only. Giannini, S.L., Hanon, E., Moris, P., Van Mechelen, M., Morel, S., Dessy, F., Fourneau, M.A., Colau, B., Suzich, J., Losonksy, G., Martin, M.T., Dubin, G., Wettendorff, M.A. Vaccine (2006)
- A well-tolerated grass pollen-specific allergy vaccine containing a novel adjuvant, monophosphoryl lipid A, reduces allergic symptoms after only four preseasonal injections. Drachenberg, K.J., Wheeler, A.W., Stuebner, P., Horak, F. Allergy (2001)
- Native and asialo-Tamm-Horsfall glycoproteins as important ligands for the detection of GalNAc beta 1-->and Gal beta 1-->4GlcNAc active lectins. Wu, A.M., Watkins, W.M., Song, S.C., Herp, A., Wu, J.H. Biochem. Biophys. Res. Commun. (1995)
- Analysis of the thrombopoietin receptor (MPL) promoter implicates GATA and Ets proteins in the coregulation of megakaryocyte-specific genes. Deveaux, S., Filipe, A., Lemarchandel, V., Ghysdael, J., Roméo, P.H., Mignotte, V. Blood (1996)
- Cloning and characterization of the human megakaryocyte growth and development factor (MGDF) gene. Chang, M.S., McNinch, J., Basu, R., Shutter, J., Hsu, R.Y., Perkins, C., Mar, V., Suggs, S., Welcher, A., Li, L. J. Biol. Chem. (1995)
- Evidence for MPL W515L/K mutations in hematopoietic stem cells in primitive myelofibrosis. Chaligné, R., James, C., Tonetti, C., Besancenot, R., Le Couédic, J.P., Fava, F., Mazurier, F., Godin, I., Maloum, K., Larbret, F., Lécluse, Y., Vainchenker, W., Giraudier, S. Blood (2007)
- Inhibition of TPO-induced MEK or mTOR activity induces opposite effects on the ploidy of human differentiating megakaryocytes. Guerriero, R., Parolini, I., Testa, U., Samoggia, P., Petrucci, E., Sargiacomo, M., Chelucci, C., Gabbianelli, M., Peschle, C. J. Cell. Sci. (2006)
- The cytoplasmic domain of Mpl receptor transduces exclusive signals in embryonic and fetal hematopoietic cells. Challier, C., Cocault, L., Berthier, R., Binart, N., Dusanter-Fourt, I., Uzan, G., Souyri, M. Blood (2002)
- The biologic properties of recombinant human thrombopoietin in the proliferation and megakaryocytic differentiation of acute myeloblastic leukemia cells. Matsumura, I., Kanakura, Y., Kato, T., Ikeda, H., Horikawa, Y., Ishikawa, J., Kitayama, H., Nishiura, T., Tomiyama, Y., Miyazaki, H., Matsuzawa, Y. Blood (1996)
- Basic sciences of the myeloproliferative diseases: pathogenic mechanisms of ET and PV. Gale, R.E. Int. J. Hematol. (2002)
- Phorbol ester PMA induces expression of the thrombopoietin receptor MPL in leukemia cells. Graf, G., Zaborski, M., Quentmeier, H., Drexler, H.G. Leuk. Lymphoma (1996)
- Circulating thrombopoietin as an in vivo growth factor for blast cells in acute myeloid leukemia. Corazza, F., Hermans, C., D'Hondt, S., Ferster, A., Kentos, A., Benoît, Y., Sariban, E. Blood (2006)
- Human thrombopoietin levels are high when thrombocytopenia is due to megakaryocyte deficiency and low when due to increased platelet destruction. Emmons, R.V., Reid, D.M., Cohen, R.L., Meng, G., Young, N.S., Dunbar, C.E., Shulman, N.R. Blood (1996)
- Endogenous serum thrombopoietin concentrations in patients with myelodysplastic syndromes. Zwierzina, H., Rollinger-Holzinger, I., Nuessler, V., Herold, M., Meng, Y.G. Leukemia (1998)