Disease relevance of Clomesone

• However, all analogues sensitized SF767 glioma cells to the cytotoxic effects of 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea, 1,3-bis(2-chloroethyl)-1-nitrosourea, and clomesone to the same degree [1].
• Clomesone also exhibited activity against other murine tumors (P388 leukemia, B16 melanoma, Lewis lung carcinoma, and M5076 sarcoma) [2].
• Clomesone exhibited significant antitumor activity against the murine L1210 leukemia implanted i.p., s.c., and intracerebrally (i.c.). Activity against s.c.-implanted tumor was largely independent of schedule and route of administration [2].
• 2-Chloroethyl (methylsulfonyl)methanesulfonate is highly active against P388 leukemia in vivo; the majority of leukemic mice treated with this compound at 50 mg/kg per day, qd 1-5, survived more than 30 days and about 37% survived for more than 60 days [3].
• Clomesone exhibited no activity in vitro against the majority of cell lines derived from solid human colorectal carcinomas [4].

High impact information on Clomesone

• Pretreatment of HT29 cells with 10 microM O6-benzylguanine for 2 hr led to a dramatic increase in the cytotoxicity produced by the chemotherapeutic agents 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) or 2-chloroethyl(methysulfonyl)methanesulfonate (Clomesone) [5].
• Cross-linking by Clomesone was observed only in cells exposed to 0.4 mM O6-methylguanine for 24 h prior to administration of the drug and for 12 h after administration, suggesting that the resynthesis of the AGT may prevent the cross-linking by Clomesone [6].
• 2-Chloroethyl (methylsulfonyl)methanesulfonate (ClEtSoSo) was more toxic to the BE (Mer-) cell line than to the HT-29 (Mer+) colon carcinoma [7].
• DNA damage and cytotoxicity of 2-chloroethyl (methylsulfonyl)methanesulfonate (NSC 338947) produced in human colon carcinoma cells with or without methylating agent pretreatment [7].
• Identification of 7-(2-hydroxyethyl)guanine as a product of alkylation of calf thymus DNA with clomesone [8].

Biological context of Clomesone

• Using this assay procedure, the stability in several aqueous media and protein binding of clomesone were evaluated [9].

Associations of Clomesone with other chemical compounds

• Development of reversed-phase HPLC assays for cyclodisone and clomesone [10].

Analytical, diagnostic and therapeutic context of Clomesone

• 2-Chloroethyl (methylsulfonyl)methanesulfonate (clomesone) is highly effective against certain experimental neoplasma and is now undergoing initial clinical trials [11].

References