High impact information on DEHYDROASCORBIC ACID

• Endothelial cells take up dehydro-L-ascorbic acid at least seven times as rapidly as they take up ascorbic acid [1].
• Spontaneous decay of oxidized ascorbic acid (dehydro-L-ascorbic acid) evaluated by high-pressure liquid chromatography [2].
• The uptake of L-ascorbate (vitamin C) and its oxidized form, dehydro-L-ascorbic acid (DHAA), was evaluated in brush border membrane vesicles isolated from adult human duodenum, jejunum and ileum [3].
• Slices of fresh lacrimal gland were incubated in a physiologic buffer and exposed to < or = 12 microM 14C-labeled ascorbic acid or dehydro-l-ascorbic acid over 40-min incubation periods [4].
• These products possess an absorption maximum above 240 nm, and most of them are electrochemically active reducing compounds which are derived from nonreducing dehydro-L-ascorbic acid through the processes of delactonization, decarboxylation, and intramolecular rearrangement [5].

Biological context of DEHYDROASCORBIC ACID

• The tissue distribution of L-ascorbic acid and dehydro-L-ascorbic acid in the guinea pigs injected intravenously with dehydro-L-ascorbic acid [6].

Anatomical context of DEHYDROASCORBIC ACID

• These findings and recent reports from transport studies do not support the concept that dehydro-L-ascorbic acid is very hydrophobic and crosses cell membranes rapidly by simple diffusion [7].
• The Km value (self inhibition) for DHA was 6-14 mmol/l. Vitamin C enters the trophoblast predominantly as L-dehydroascorbic acid [8].
• The results suggest a mechanism of facilitated diffusion for the uptake of dehydro-L-ascorbic acid in renal brush-border membranes [9].
• Uptake of L-ascorbic acid and L-dehydroascorbic acid by human erythrocytes and HeLa cells [10].

Associations of DEHYDROASCORBIC ACID with other chemical compounds

• DNA incubated with d-glucose, dihydroxyacetone, l-ascorbic or l-dehydroascorbic acid shows a signal inhibition indicating the formation of CEG in vitro [11].
• A new analytical procedure for the simultaneous determination of L-ascorbic acid (AA), isoascorbic acid (IAA), L-dehydroascorbic acid (DHAA), and isodehydroascorbic acid (IDHAA) in food by high-performance liquid chromatography (HPLC) is developed [12].

Gene context of DEHYDROASCORBIC ACID

• Phenolic compounds, vitamin C (L-ascorbic acid and L-dehydroascorbic acid), and antioxidant capacity were evaluated in orange juices manufactured by different techniques [13].

Analytical, diagnostic and therapeutic context of DEHYDROASCORBIC ACID

• Plasma L-ascorbic acid concentrations were decreased, whereas L-dehydroascorbic acid concentrations were increased in ALL, HD and NHL patients before and after treatment [14].

References