Disease relevance of ascorbic acid

• L-Ascorbic acid and D-isoascorbic acid in a common cold survey [1].
• Four of the animals were given, in addition, 200 mg erythorbic acid/kg body weight orally each day [2].
• Bubbling oxygen through the reaction mixture and the addition of H2O2 or transition metal ions into the reaction mixture enhanced the phage inactivation by D-isoascorbic acid [3].

Psychiatry related information on ascorbic acid

• It is therefore necessary that in abstaining from heroin dependence, the heroin abusers should acquire sufficient quantities of antioxidants such as VC, VE and beta-CAR [4].

High impact information on ascorbic acid

• Using electron paramagnetic resonance, we monitored the coronary sinus concentration of ascorbate free radical (Asc*-), a measure of total oxidative flux [5].
• Erythorbic acid is a potent enhancer of nonheme-iron absorption [6].
• However, it may play a major role in enhancing iron bioavailability from mixed diets that include foods preserved with erythorbic acid [6].
• An increase in ROS induced oxidative stress in the cells, causing an oxidation of the ASC and GSH redox pairs; however, it had no effect on PAL activity and did not induce cell death when it was generated at low concentrations [7].
• Consumption of erythorbic acid resulted in the presence of erythorbic acid in mononuclear leukocytes [8].

Biological context of ascorbic acid

• Ascorbic acid control on cell division is found to be specific, since isoascorbic acid is wholly ineffective [9].
• Some ascorbic acid derivatives (e.g., isoascorbic acid) had properties similar to those of ascorbic acid, whereas several reducing agents could, in the presence of added iron salts, cause both a lipid peroxidation and a loss of [3H]spiroperidol binding.(ABSTRACT TRUNCATED AT 250 WORDS)[10]
• Apoptosis was reduced by more than 90% after treatment of oxidized LDL with DHAA, whereas after incubation with either ascorbic or isoascorbic acid there was no such reduction [11].
• Effect of smoking on erythorbic acid pharmacokinetics [12].
• Three additives (erythorbic acid, chlorine dioxide and beet red) were positive only in the Ames test, although their mutagenic potentials were relatively weak, while 43 additives were positive only in the chromosome test [13].

Anatomical context of ascorbic acid

• Supplementation of serum-free culture medium with 25 microM ascorbic or isoascorbic acid only partially protected macrophages from apoptosis, whereas dehydroascorbic acid (DHAA) completely inhibited apoptosis induced by either Cu2+- or AAPH-oxidized LDL [11].
• Evidence for an action of araboascorbic acid on dopaminergic pathways of the corpus striatum [14].
• In the erythorbic acid-treated mice, erythorbic acid is well absorbed by the gastrointestinal tract, enters the blood stream, and is rapidly excreted in the urine [15].
• 5. Buccal mucosa was also permeable to dehydroascorbic acid and D-isoascorbic acid [16].
• Comparison of absorption of erythorbic acid and ascorbic acid in guinea pig small intestine [17].

Associations of ascorbic acid with other chemical compounds

• Protection against in vivo lipid peroxidation similar to that provided by ascorbic acid was also found when vitamin C-deficient guinea pigs were pretreated with isoascorbic acid, reduced glutathione, alpha-tocopherol or beta-carotene [18].
• The paper describes a convenient, rapid, and reproducible method for the synthesis of stable dispersions of uniform gold nanoparticles at ambient temperatures by mixing aqueous solutions of tetrachloroauric acid and iso-ascorbic acid [19].
• The interaction between dithranol and heptakis(2,3,6-tri-O-methyl)-beta-cyclodextrin (TMBCyD) has been investigated in aqueous solution containing isoascorbic acid (0.2% w/v) as antioxidant and in the solid state [20].
• In this work, we considered additives with primary antioxidant technological function for which an acceptable daily intake (ADI) was established by the Scientific Committee for Food (SCF): gallates, butylated hydroxyanisole (BHA), butylated hydroxytoluene (BHT) and erythorbic acid [21].
• Mechanistic studies using (1-pyrenyl)alkanoic acids () as sensitizers suggest that the electron transport is mainly initiated by the reductive quenching of the singlet excited state of the pyrene by Asc(-) and proceeds by a mechanism involving electron exchange between the pyrenes located at the inner and outer interface across the vesicle bilayer [22].

Gene context of ascorbic acid

• Compared with the AVM group before treatment, plasma NO, and LPO in plasma and in erythrocyte of the AVM group post treatment significantly decreased (P < 0.05), whereas plasma VC, VE and beta-CAR as well as erythrocytic SOD, CAT and GSH-Px of the AVM group post treatment significantly increased (P < 0.05) [23].
• On the other hand, the cytotoxic activity of sodium ascorbate, isoascorbic acid, hydrogen peroxide and gallic acid was more effectively inhibited by catalase [24].

Analytical, diagnostic and therapeutic context of ascorbic acid

• RESULTS: In the control dogs Asc*- rose from 3.2 +/- SD 0.5 nmol/l to 4.8 +/- 1.1 nmol/l with reperfusion, a 50% rise [5].
• With the meals used, 7-23% of the apparent vitamin C in plasma obtained 2 h after the ingestion of the meals was actually erythorbic acid when analyzed by HPLC [25].
• The reaction mechanism of virus inactivation by D-isoascorbic acid was investigated using phage J1 as a model system [3].

References