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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

Allopregnanolone     1-[(8S,9S,10S,13S,14S,17S)-3- hydroxy-10,13...

Synonyms: SureCN56665, CHEBI:50168, AC1L2XNW, CTK4B5879, LMST02030155, ...
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Disease relevance of Allopregnanolone


Psychiatry related information on Allopregnanolone

  • Based on these findings, it could be inferred that the increase of brain Allo content elicited by fluoxetine and norfluoxetine, rather than the inhibition selective of 5-HT reuptake, may be operative in the fluoxetine-induced remission of the behavioral abnormalities associated with mood disorders [2].

High impact information on Allopregnanolone


Biological context of Allopregnanolone

  • The concomitant reduction in peripheral ALLO levels provides further evidence of alterations in the balance between cortical excitation and inhibition during the puerperium [5].


  1. Allopregnanolone, a progesterone metabolite, enhances behavioral recovery and decreases neuronal loss after traumatic brain injury. He, J., Hoffman, S.W., Stein, D.G. Restorative neurology and neuroscience. (2004) [Pubmed]
  2. Fluoxetine and norfluoxetine stereospecifically and selectively increase brain neurosteroid content at doses that are inactive on 5-HT reuptake. Pinna, G., Costa, E., Guidotti, A. Psychopharmacology (Berl.) (2006) [Pubmed]
  3. Fluoxetine and norfluoxetine stereospecifically facilitate pentobarbital sedation by increasing neurosteroids. Pinna, G., Costa, E., Guidotti, A. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  4. Differential responses of expressed recombinant human gamma-aminobutyric acidA receptors to neurosteroids. Lan, N.C., Gee, K.W., Bolger, M.B., Chen, J.S. J. Neurochem. (1991) [Pubmed]
  5. Preliminary evidence of reduced occipital GABA concentrations in puerperal women: a 1H-MRS study. Epperson, C.N., Gueorguieva, R., Czarkowski, K.A., Stiklus, S., Sellers, E., Krystal, J.H., Rothman, D.L., Mason, G.F. Psychopharmacology (Berl.) (2006) [Pubmed]
  6. The interaction of neuroactive steroids and GABA in the development of neuropsychiatric disorders in women. Amin, Z., Mason, G.F., Cavus, I., Krystal, J.H., Rothman, D.L., Epperson, C.N. Pharmacol. Biochem. Behav. (2006) [Pubmed]
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