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Chemical Compound Review

AC1L2XXN     (2S)-2-[[(2S)-1-[(2S)-2- [[(2S)-2-[2-[[(2S)...

Synonyms: AC1Q1HEF, AR-1J3021, LS-191232, 9-Des-arg-BK, 1-8-Bradykinin, ...
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Disease relevance of 1-Des-arg-bradykinin

  • Time- and collision energy-resolved surface-induced dissociation (SID) of des-Arg(1)- and des-Arg(9)-bradykinin on a fluorinated self-assembled monolayer (SAM) surface was studied by use of a novel Fourier transform ion cyclotron resonance mass spectrometer (FT-ICR MS) specially equipped to perform SID experiments [1].
  • Similarly, the i.t. injection of DABK elicited thermal hyperalgesia in WT mice, but not in B(1)R KO mice [2].
  • The B(1) receptor agonist, des-Arg(9)-Bradykinin (BK) (3.2 - 32.5 nmol), evoked dose-dependent increases in MAP and tachycardia during the first 10 min post-injection in STZ-diabetic rats only [3].

High impact information on 1-Des-arg-bradykinin


Chemical compound and disease context of 1-Des-arg-bradykinin


Biological context of 1-Des-arg-bradykinin


Anatomical context of 1-Des-arg-bradykinin


Gene context of 1-Des-arg-bradykinin

  • Activation of MAPK by dABK is mediated via a cholera toxin-sensitive pathway and appears to involve protein kinase C, Src kinase, and MAPK kinase [9].


  1. Shattering of Peptide ions on self-assembled monolayer surfaces. Laskin, J., Bailey, T.H., Futrell, J.H. J. Am. Chem. Soc. (2003) [Pubmed]
  2. The use of kinin B1 and B2 receptor knockout mice and selective antagonists to characterize the nociceptive responses caused by kinins at the spinal level. Ferreira, J., Campos, M.M., Araújo, R., Bader, M., Pesquero, J.B., Calixto, J.B. Neuropharmacology (2002) [Pubmed]
  3. Pharmacological characterization of the cardiovascular responses elicited by kinin B(1) and B(2) receptor agonists in the spinal cord of streptozotocin-diabetic rats. Cloutier, F., Couture, R. Br. J. Pharmacol. (2000) [Pubmed]
  4. Overexpression of kinin B1 receptors induces hypertensive response to des-Arg9-bradykinin and susceptibility to inflammation. Ni, A., Yin, H., Agata, J., Yang, Z., Chao, L., Chao, J. J. Biol. Chem. (2003) [Pubmed]
  5. Up-regulation of kinin B1 receptor in the lung of streptozotocin-diabetic rat: autoradiographic and functional evidence. Vianna, R.M., Ongali, B., Regoli, D., Calixto, J.B., Couture, R. Br. J. Pharmacol. (2003) [Pubmed]
  6. Bradykinin and des-Arg(9)-bradykinin metabolic pathways and kinetics of activation of human plasma. Cyr, M., Lepage, Y., Blais, C., Gervais, N., Cugno, M., Rouleau, J.L., Adam, A. Am. J. Physiol. Heart Circ. Physiol. (2001) [Pubmed]
  7. B(1) and B(2) bradykinin receptors on adventitial fibroblasts of cerebral arteries are coupled to recombinant eNOS. Tsutsui, M., Onoue, H., Iida, Y., Smith, L., O'Brien, T., Katusic, Z.S. Am. J. Physiol. Heart Circ. Physiol. (2000) [Pubmed]
  8. Triphasic vascular responses to bradykinin in the mesenteric resistance artery of the rat. Nawa, H., Kawasaki, H., Nakatsuma, A., Isobe, S., Kurosaki, Y. Eur. J. Pharmacol. (2001) [Pubmed]
  9. Induction of B(1)-kinin receptors in vascular smooth muscle cells: cellular mechanisms of map kinase activation. Christopher, J., Velarde, V., Jaffa, A.A. Hypertension (2001) [Pubmed]
  10. Functional characterization of bradykinin analogues on recombinant human bradykinin B(1) and B(2) receptors. Simpson, P.B., Woollacott, A.J., Hill, R.G., Seabrook, G.R. Eur. J. Pharmacol. (2000) [Pubmed]
  11. Coronary vasomotor response to the selective B1-kinin-receptor agonist Des-Arg9-bradykinin in humans. Aptecar, E., Lecorvoisier, P., Teiger, E., Garot, P., Dupouy, P., Sediame, S., Vermes, E., Loisance, D., Hittinger, L., Dubois-Rande, J.L., Montagne, O. J. Heart Lung Transplant. (2006) [Pubmed]
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