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Chemical Compound Review

bismuth(3+)     bismuth(+3) cation

Synonyms: HMDB02196, CTK8E6520, Bi(3+), AC1L2Y4B, 23713-46-4, ...
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Disease relevance of Bi(3+)


High impact information on Bi(3+)

  • Of the dopants examined, Bi(3+) most enhanced osteoblast long-term calcium-containing mineral deposition [2].
  • The present in vitro study doped hydroxyapatite (HA) with various metal cations (Mg(2+), Zn(2+), La(3+), Y(3+), In(3+), and Bi(3+)) in an attempt to enhance properties of HA pertinent to orthopedic and dental applications [2].
  • NRK-52E cells exposed to 100 microM Bi(3+) or more died by necrosis, as was demonstrated by nuclear staining with Hoechst 33258 and flow cytometry using Alexa(488)-labeled Annexin-V and the vital nuclear dye TOPRO-3 [3].
  • The active C319A mutant of the bacterial enzyme displays a significantly reduced sensitivity toward inactivation by Bi(EDTA) compared with the wild-type enzyme, consistent with binding of Bi(3+) to the active site cysteine (Cys(319)) as the mechanism of enzyme inactivation [4].
  • We introduced a simple chemical method to synthesize semimetal bismuth nanoparticles in N,N-dimethylformamide (DMF) by reducing Bi(3+) with sodium borohydride (NaBH(4)) in the presence of poly(vinylpyrroldone) (PVP) at room temperature [5].


  1. Activities of bismuth thiols against staphylococci and staphylococcal biofilms. Domenico, P., Baldassarri, L., Schoch, P.E., Kaehler, K., Sasatsu, M., Cunha, B.A. Antimicrob. Agents Chemother. (2001) [Pubmed]
  2. Osteoblast response to hydroxyapatite doped with divalent and trivalent cations. Webster, T.J., Massa-Schlueter, E.A., Smith, J.L., Slamovich, E.B. Biomaterials (2004) [Pubmed]
  3. Pathways of proximal tubular cell death in bismuth nephrotoxicity. Leussink, B.T., Nagelkerke, J.F., van de Water, B., Slikkerveer, A., van der Voet, G.B., Srinivasan, A., Bruijn, J.A., de Wolff, F.A., de Heer, E. Toxicol. Appl. Pharmacol. (2002) [Pubmed]
  4. Inhibition of urease by bismuth(III): Implications for the mechanism of action of bismuth drugs. Zhang, L., Mulrooney, S.B., Leung, A.F., Zeng, Y., Ko, B.B., Hausinger, R.P., Sun, H. Biometals (2006) [Pubmed]
  5. Size control of semimetal bismuth nanoparticles and the UV-visible and IR absorption spectra. Wang, Y.W., Hong, B.H., Kim, K.S. The journal of physical chemistry. B, Condensed matter, materials, surfaces, interfaces & biophysical. (2005) [Pubmed]
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