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Chemical Compound Review:

AG-E-67534 2-amino-4-chloro-3-hydroxy- benzoic acid

Synonyms: SureCN2408682, C7H6ClNO3, CTK4F1122, AR-1D8358, DB04598, ...

Walsh, J.L. et al., Blight, A.R. et al., Yates, J.R. et al., Naritsin, D.B. et al., Heyes, M.P., et al.

Yates, Heyes, Blight,

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Disease relevance of 4-Chloro-3-hydroxyanthranilic acid

The results suggest that QUIN synthesis inhibitors such as 4-chloro-3-hydroxyanthranilic acid may become of value in brain diseases that are caused by hyperphysiological quantities of QUIN [1].

High impact information on 4-Chloro-3-hydroxyanthranilic acid

We evaluated whether 4-chloro-3-hydroxyanthranilate (4Cl-3HAA), an inhibitor of 3-hydroxyanthranilate-3,4-dioxygenase, reduces QUIN accumulations in this model and influences the progression of neurological deficits [2].
Metabolism of L-tryptophan to kynurenate and quinolinate in the central nervous system: effects of 6-chlorotryptophan and 4-chloro-3-hydroxyanthranilate [3].
4-chloro-3-hydroxyanthranilate reduces local quinolinic acid synthesis, improves functional recovery, and preserves white matter after spinal cord injury [4].
In the present study, the ability of the QUIN synthesis inhibitor 4-chloro-3-hydroxyanthranilic acid to attenuate the production of QUIN was assessed in the hippocampus of awake rats [1].
4-Chloro-3-hydroxyanthranilate is a potent inhibitor of QUIN production by macrophages and reduces QUIN accumulations in spinal cord injury [5].

Gene context of 4-Chloro-3-hydroxyanthranilic acid

Non-competitive inhibition of 3-hydroxyanthranilate-3,4-dioxygenase by 4-chloro-3-hydroxyanthranilic acid in whole brain of rat [6].

Analytical, diagnostic and therapeutic context of 4-Chloro-3-hydroxyanthranilic acid

After 3 h, 4-chloro-3-hydroxyanthranilic acid (3 microM-3 mM) was included in the perfusion medium, and dialysis was continued for another 3 h [1].

References

4-Chloro-3-hydroxyanthranilate inhibits quinolinate production in the rat hippocampus in vivo. Walsh, J.L., Wu, H.Q., Ungerstedt, U., Schwarcz, R. Brain Res. Bull. (1994) [Pubmed]
Quinolinic acid accumulation and functional deficits following experimental spinal cord injury. Blight, A.R., Cohen, T.I., Saito, K., Heyes, M.P. Brain (1995) [Pubmed]
Metabolism of L-tryptophan to kynurenate and quinolinate in the central nervous system: effects of 6-chlorotryptophan and 4-chloro-3-hydroxyanthranilate. Naritsin, D.B., Saito, K., Markey, S.P., Chen, C.Y., Heyes, M.P. J. Neurochem. (1995) [Pubmed]
4-chloro-3-hydroxyanthranilate reduces local quinolinic acid synthesis, improves functional recovery, and preserves white matter after spinal cord injury. Yates, J.R., Heyes, M.P., Blight, A.R. J. Neurotrauma (2006) [Pubmed]
The kynurenine pathway and neurologic disease. Therapeutic strategies. Heyes, M.P. Adv. Exp. Med. Biol. (1996) [Pubmed]
Non-competitive inhibition of 3-hydroxyanthranilate-3,4-dioxygenase by 4-chloro-3-hydroxyanthranilic acid in whole brain of rat. Ji, X.D., Nishimura, M., Heyes, M.P. Adv. Exp. Med. Biol. (1991) [Pubmed]

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