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Gene Review

HAAO  -  3-hydroxyanthranilate 3,4-dioxygenase

Homo sapiens

Synonyms: 3-HAO, 3-hydroxyanthranilate oxygenase, 3-hydroxyanthranilic acid dioxygenase, HAD, HAO
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Disease relevance of HAAO


Psychiatry related information on HAAO


High impact information on HAAO


Biological context of HAAO

  • The adenine-treated rats were divided into the following 3 groups, that is, the group experienced no treatment (control), the group given our Chinese herbal medicine (HAO), and the group given vitamin D3 (VD3) medication [5].

Anatomical context of HAAO

  • METHODS: Eighteen patients were allocated to hepatic artery occlusion for 16 h followed by intraportal 5-fluorouracil (5-Fu) infusion (1000 mg/m(2)) for 5 days every sixth week (HAO) [9].

Associations of HAAO with chemical compounds


Analytical, diagnostic and therapeutic context of HAAO


  1. Molecular cloning and functional expression of human 3-hydroxyanthranilic-acid dioxygenase. Malherbe, P., Köhler, C., Da Prada, M., Lang, G., Kiefer, V., Schwarcz, R., Lahm, H.W., Cesura, A.M. J. Biol. Chem. (1994) [Pubmed]
  2. Quinolinic acid catabolism is increased in cerebellum of patients with dominantly inherited olivopontocerebellar atrophy. Kish, S.J., Du, F., Parks, D.A., Robitaille, Y., Ball, M.J., Schut, L., Hornykiewicz, O., Schwarcz, R. Ann. Neurol. (1991) [Pubmed]
  3. Changes of low back pain after vascular reconstruction for abdominal aortic aneurysm and high aortic occlusion: a retrospective study. Takeyachi, Y., Yabuki, S., Arai, I., Midorikawa, H., Hoshino, S., Chiba, K., Kikuchi, S. Surgical neurology. (2006) [Pubmed]
  4. Cloning of human 3-hydroxyanthranilic acid dioxygenase in Escherichia coli: characterisation of the purified enzyme and its in vitro inhibition by Zn2+. Calderone, V., Trabucco, M., Menin, V., Negro, A., Zanotti, G. Biochim. Biophys. Acta (2002) [Pubmed]
  5. Effects of the Chinese herbal medicine based on Hachimi-jio-gan in male rats with the adenine-induced osteopenia. Ogirima, T., Tano, K., Kanehara, M., Gao, M., Wang, X., Guo, Y., Zhang, Y., Guo, L., Ishida, T. Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan / sponsored by All-China Association of Traditional Chinese Medicine, Academy of Traditional Chinese Medicine. (2005) [Pubmed]
  6. Interaction of tetracycline with aluminum and iron hydrous oxides. Gu, C., Karthikeyan, K.G. Environ. Sci. Technol. (2005) [Pubmed]
  7. 3-Hydroxyanthranilate oxygenase activity is increased in the brains of Huntington disease victims. Schwarcz, R., Okuno, E., White, R.J., Bird, E.D., Whetsell, W.O. Proc. Natl. Acad. Sci. U.S.A. (1988) [Pubmed]
  8. Quinolinic acid accumulation and functional deficits following experimental spinal cord injury. Blight, A.R., Cohen, T.I., Saito, K., Heyes, M.P. Brain (1995) [Pubmed]
  9. A comparison between hepatic artery ligation and portal 5-Fu infusion versus 5-Fu intra arterial infusion for colorectal liver metastases. Naredi, P., Oman, M., Blind, P.J., Lindnér, P., Gustavsson, B., Hafström, L. European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology. (2003) [Pubmed]
  10. Different kynurenine pathway enzymes limit quinolinic acid formation by various human cell types. Heyes, M.P., Chen, C.Y., Major, E.O., Saito, K. Biochem. J. (1997) [Pubmed]
  11. Effects of oxygen on 3-hydroxyanthranilate oxidase of the kynurenine pathway. Dang, Y., Xia, C., Brown, O.R. Free Radic. Biol. Med. (1998) [Pubmed]
  12. Regulation of the kynurenine metabolic pathway by interferon-gamma in murine cloned macrophages and microglial cells. Alberati-Giani, D., Ricciardi-Castagnoli, P., Köhler, C., Cesura, A.M. J. Neurochem. (1996) [Pubmed]
  13. Profiling dendritic cell maturation with dedicated microarrays. McIlroy, D., Tanguy-Royer, S., Le Meur, N., Guisle, I., Royer, P.J., Léger, J., Meflah, K., Grégoire, M. J. Leukoc. Biol. (2005) [Pubmed]
  14. Sorption of the antimicrobial ciprofloxacin to aluminum and iron hydrous oxides. Gu, C., Karthikeyan, K.G. Environ. Sci. Technol. (2005) [Pubmed]
  15. IFN-beta1b induces kynurenine pathway metabolism in human macrophages: potential implications for multiple sclerosis treatment. Guillemin, G.J., Kerr, S.J., Pemberton, L.A., Smith, D.G., Smythe, G.A., Armati, P.J., Brew, B.J. J. Interferon Cytokine Res. (2001) [Pubmed]
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