Chemical Compound Review:
Metadoxil 4,5-bis(hydroxymethyl)-2- methyl-pyridin-3...
Synonyms:
Metasin, Metadoxine, Metadoxil (TN), AG-G-96419, STOCK6S-68822, ...
Gutiérrez-Ruiz,
Bucio,
Correa,
Souza,
Hernández,
Gómez-Quiroz,
Kershenobich,
Caballería,
Parés,
Brú,
Mercader,
García Plaza,
Caballería,
Clemente,
Rodrigo,
Rodés,
Muriel,
Deheza,
Guerrini,
Gentili,
Nelli,
Guazzelli,
- Treatment of alcoholic fatty liver: is the metabolic effect of metadoxine the only reason for improved liver function? Stefanini, G.F., Addolorato, G., Caputo, F., Bernardi, M., Gasbarrini, G. J. Hepatol. (1999)
- Metadoxine accelerates fatty liver recovery in alcoholic patients: results of a randomized double-blind, placebo-control trial. Spanish Group for the Study of Alcoholic Fatty Liver. Caballería, J., Parés, A., Brú, C., Mercader, J., García Plaza, A., Caballería, L., Clemente, G., Rodrigo, L., Rodés, J. J. Hepatol. (1998)
- Changes in expression of the albumin, fibronectin and type I procollagen genes in CCl4-induced liver fibrosis: effect of pyridoxol L,2-pyrrolidon-5 carboxylate. Arosio, B., Santambrogio, D., Gagliano, N., Annoni, G. Pharmacol. Toxicol. (1993)
- Long-term ethanol administration enhances age-dependent modulation of redox state in central and peripheral organs of rat: protection by metadoxine. Calabrese, V., Randazzo, G., Ragusa, N., Rizza, V. Drugs under experimental and clinical research. (1998)
- Effect of metadoxine on striatal dopamine levels in C57 black mice. Fornai, F., Grazia Alessandrì, M., Bonuccelli, U., Scalori, V., Corsini, G.U. J. Pharm. Pharmacol. (1993)
- Metadoxine (pyrrolidone carboxylate of pyridoxine) antagonizes the locomotor-stimulatory effect of ethanol in mice. Garau, B., Fadda, F., Melis, F., Gelso, E., Gessa, G.L. Alcohol Alcohol. (1992)
- A follow up study on the efficacy of metadoxine in the treatment of alcohol dependence. Guerrini, I., Gentili, C., Nelli, G., Guazzelli, M. Substance abuse treatment, prevention, and policy (2006)
- Application of stability-indicating HPTLC method for quantitative determination of metadoxine in pharmaceutical dosage form. Kaul, N., Agrawal, H., Patil, B., Kakad, A., Dhaneshwar, S.R. Farmaco (2005)
- Metadoxine prevents damage produced by ethanol and acetaldehyde in hepatocyte and hepatic stellate cells in culture. Gutiérrez-Ruiz, M.C., Bucio, L., Correa, A., Souza, V., Hernández, E., Gómez-Quiroz, L.E., Kershenobich, D. Pharmacol. Res. (2001)
- Fibrosis and glycogen stores depletion induced by prolonged biliary obstruction in the rat are ameliorated by metadoxine. Muriel, P., Deheza, R. Liver Int. (2003)
- Alcoholic abstinence syndrome: short-term treatment with metadoxine. Bono, G., Sinforiani, E., Merlo, P., Belloni, G., Soldati, M., Gelso, E. International journal of clinical pharmacology research. (1991)
- Action of metadoxine on isolated human and rat alcohol and aldehyde dehydrogenases. Effect on enzymes in chronic ethanol-fed rats. Parés, X., Moreno, A., Peralba, J.M., Font, M., Bruseghini, L., Esteras, A. Methods and findings in experimental and clinical pharmacology. (1991)