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Gene Review

Adh1  -  alcohol dehydrogenase 1 (class I)

Rattus norvegicus

Synonyms: Adh, Adh-1, Adh1a, Adh1c, Alcohol dehydrogenase 1, ...
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Disease relevance of Adh1


Psychiatry related information on Adh1


High impact information on Adh1

  • This negligible metabolism was predictable from the low affinity of gastric ADH for ethanol [10].
  • In contrast, gastric ADH has a high affinity for octanol, and 66% of this compound was metabolized during gastric absorption [10].
  • Compared with the liver, FAEE synthase activity in the pancreas is greater, whereas that of ADH is much less [11].
  • Inhibition of ADH by 4MP prevented ethanol-induced cell activation [12].
  • These changes were prevented by the antioxidant vitamin E. Stellate cells exhibited ethanol-inducible ADH activity [12].

Chemical compound and disease context of Adh1


Biological context of Adh1


Anatomical context of Adh1


Associations of Adh1 with chemical compounds


Physical interactions of Adh1


Regulatory relationships of Adh1


Other interactions of Adh1


Analytical, diagnostic and therapeutic context of Adh1


  1. Effect of aging on in vivo and in vitro ethanol metabolism and its toxicity in F344 rats. Seitz, H.K., Meydani, M., Ferschke, I., Simanowski, U.A., Boesche, J., Bogusz, M., Hoepker, W.W., Blumberg, J.B., Russell, R.M. Gastroenterology (1989) [Pubmed]
  2. Kinetic properties of alcohol dehydrogenase in hepatocellular carcinoma and normal tissues of rat. Cederbaum, A.I., Rubin, E. Cancer Res. (1976) [Pubmed]
  3. Effects of thyroxine on the expression of alcohol dehydrogenase in rat liver and kidney. Dipple, K.M., Qulali, M., Ross, R.A., Crabb, D.W. Hepatology (1993) [Pubmed]
  4. The combined effects of protein deficiency and chronic ethanol administration on rat ethanol metabolism. Wilson, J.S., Korsten, M.A., Lieber, C.S. Hepatology (1986) [Pubmed]
  5. Influence of the immunization against heterologous alcohol dehydrogenase on liver alcohol dehydrogenase isozymes and alcohol abuse of rats. Pshezhetsky, A.V., Danilova, R.A., Fedorova, I.M., Sagimbaeva, S.K., Pervushina, S.V., Obuchova, M.A., Svedas, V.K., Ashmarin, I.P. Eur. J. Biochem. (1993) [Pubmed]
  6. Oxidation of 3-butene-1,2-diol by alcohol dehydrogenase. Kemper, R.A., Elfarra, A.A. Chem. Res. Toxicol. (1996) [Pubmed]
  7. Disruption of the retinoid signalling pathway causes a deposition of amyloid beta in the adult rat brain. Corcoran, J.P., So, P.L., Maden, M. Eur. J. Neurosci. (2004) [Pubmed]
  8. Pyrazole, an alcohol dehydrogenase inhibitor, has dual effects on N-methyl-D-aspartate receptors of hippocampal pyramidal cells: agonist and noncompetitive antagonist. Pereira, E.F., Aracava, Y., Aronstam, R.S., Barreiro, E.J., Albuquerque, E.X. J. Pharmacol. Exp. Ther. (1992) [Pubmed]
  9. Detection of a CA repeat polymorphism in the rat class I alcohol dehydrogenase gene. Carr, L.G., Koivisto, T., Eriksson, C.J., Crabb, D.W. Alcohol. Clin. Exp. Res. (1993) [Pubmed]
  10. First-pass gastric mucosal metabolism of ethanol is negligible in the rat. Smith, T., DeMaster, E.G., Furne, J.K., Springfield, J., Levitt, M.D. J. Clin. Invest. (1992) [Pubmed]
  11. Ethanol metabolism and transcription factor activation in pancreatic acinar cells in rats. Gukovskaya, A.S., Mouria, M., Gukovsky, I., Reyes, C.N., Kasho, V.N., Faller, L.D., Pandol, S.J. Gastroenterology (2002) [Pubmed]
  12. Does alcohol directly stimulate pancreatic fibrogenesis? Studies with rat pancreatic stellate cells. Apte, M.V., Phillips, P.A., Fahmy, R.G., Darby, S.J., Rodgers, S.C., McCaughan, G.W., Korsten, M.A., Pirola, R.C., Naidoo, D., Wilson, J.S. Gastroenterology (2000) [Pubmed]
  13. Endotoxin enhances liver alcohol dehydrogenase by action through upstream stimulatory factor but not by nuclear factor-kappa B. Potter, J.J., Rennie-Tankersley, L., Mezey, E. J. Biol. Chem. (2003) [Pubmed]
  14. Activation of the microsomal glutathione-S-transferase and reduction of the glutathione dependent protection against lipid peroxidation by acrolein. Haenen, G.R., Vermeulen, N.P., Tai Tin Tsoi, J.N., Ragetli, H.M., Timmerman, H., Blast, A. Biochem. Pharmacol. (1988) [Pubmed]
  15. Induction of alcohol dehydrogenase activity and mRNA in hepatoma cells by dexamethasone. Wolfla, C.E., Ross, R.A., Crabb, D.W. Arch. Biochem. Biophys. (1988) [Pubmed]
  16. Formation and export of the glutathione conjugate of 4-hydroxy-2, 3-E-nonenal (4-HNE) in hepatoma cells. Tjalkens, R.B., Cook, L.W., Petersen, D.R. Arch. Biochem. Biophys. (1999) [Pubmed]
  17. Post-transcriptional regulation of sterol regulatory element-binding protein-1 by ethanol induces class I alcohol dehydrogenase in rat liver. He, L., Simmen, F.A., Ronis, M.J., Badger, T.M. J. Biol. Chem. (2004) [Pubmed]
  18. Distribution of alcohol and sorbitol dehydrogenases. Assessment of mRNA species in mammalian tissues. Estonius, M., Danielsson, O., Karlsson, C., Persson, H., Jörnvall, H., Höög, J.O. Eur. J. Biochem. (1993) [Pubmed]
  19. Ethanol induction of class I alcohol dehydrogenase expression in the rat occurs through alterations in CCAAT/enhancer binding proteins beta and gamma. He, L., Ronis, M.J., Badger, T.M. J. Biol. Chem. (2002) [Pubmed]
  20. Immunocytochemical and biochemical demonstration of formaldhyde dehydrogenase (class III alcohol dehydrogenase) in the nucleus. Iborra, F.J., Renau-Piqueras, J., Portoles, M., Boleda, M.D., Guerri, C., Pares, X. J. Histochem. Cytochem. (1992) [Pubmed]
  21. Expression, localization and potential physiological significance of alcohol dehydrogenase in the gastrointestinal tract. Vaglenova, J., Martínez, S.E., Porté, S., Duester, G., Farrés, J., Parés, X. Eur. J. Biochem. (2003) [Pubmed]
  22. Changes in the activity of alcohol dehydrogenase isoenzymes during the estrus cycle in the vagina of the rat. Nowak, C., Maly, I.P., Sasse, D. Histochem. J. (2000) [Pubmed]
  23. Alcohol and aldehyde dehydrogenase activity in the stomach and small intestine of rats poisoned with methanol. Chrostek, L., Szczepura, D., Szmitkowski, M., Jelski, W., Wierzchowski, J. Human & experimental toxicology. (2001) [Pubmed]
  24. Mammalian alcohol dehydrogenase - functional and structural implications. Höög, J.O., Hedberg, J.J., Strömberg, P., Svensson, S. J. Biomed. Sci. (2001) [Pubmed]
  25. Complete amino acid sequence of rat liver alcohol dehydrogenase deduced from the cDNA sequence. Crabb, D.W., Edenberg, H.J. Gene (1986) [Pubmed]
  26. Effect of dihydrotestosterone on rat liver alcohol dehydrogenase activity. Mezey, E., Potter, J.J. Hepatology (1982) [Pubmed]
  27. Alcohol dehydrogenase-coupled spectrophotometric assay of epoxide hydratase activity. Guengerich, F.P., Mason, P.S. Anal. Biochem. (1980) [Pubmed]
  28. Effect of STAT5b on rat liver alcohol dehydrogenase. Potter, J.J., Mezey, E. Arch. Biochem. Biophys. (2001) [Pubmed]
  29. Formation of 1,N2- and N2,3-ethenoguanine from 2-halooxiranes: isotopic labeling studies and isolation of a hemiaminal derivative of N2-(2-oxoethyl)guanine. Guengerich, F.P., Persmark, M., Humphreys, W.G. Chem. Res. Toxicol. (1993) [Pubmed]
  30. Regulation of rat alcohol dehydrogenase by cyclic AMP in primary hepatocyte culture. Potter, J.J., MacDougald, O.A., Mezey, E. Arch. Biochem. Biophys. (1995) [Pubmed]
  31. Sorbitol dehydrogenase: cDNA coding for the rat enzyme. Variations within the alcohol dehydrogenase family independent of quaternary structure and metal content. Karlsson, C., Jörnvall, H., Höög, J.O. Eur. J. Biochem. (1991) [Pubmed]
  32. Receptor-mediated endocytosis of lactate dehydrogenase M4 by liver macrophages: a mechanism for elimination of enzymes from plasma. Evidence for competition by creatine kinase MM, adenylate kinase, malate, and alcohol dehydrogenase. Smit, M.J., Duursma, A.M., Bouma, J.M., Gruber, M. J. Biol. Chem. (1987) [Pubmed]
  33. Effect of antiandrogen flutamide on measures of hepatic regeneration in rats. Svanas, G.W., Eagon, P.K., Elm, M., Makowka, L., Podesta, L., Chapchap, P., Kahn, D., Starzl, T.E., Van Thiel, D.H. Dig. Dis. Sci. (1989) [Pubmed]
  34. Buthionine sulfoximine inhibition of glutathione biosynthesis enhances hepatic lipid peroxidation in rats during acute ethanol intoxication. Kera, Y., Ohbora, Y., Komura, S. Alcohol Alcohol. (1989) [Pubmed]
  35. Rabbit liver class III alcohol dehydrogenase: a cathodic isoform with formaldehyde dehydrogenase activity. Keung, W.M., Kunze, L., Holmquist, B. Alcohol. Clin. Exp. Res. (1995) [Pubmed]
  36. Effects of thyroidectomy and triiodothyronine administration on rat liver alcohol dehydrogenase. Mezey, E., Potter, J.J. Gastroenterology (1981) [Pubmed]
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