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Chemical Compound Review

Org-2058     (8R,9S,10R,13S,14S,16R,17S)- 16-ethyl-17-(2...

Synonyms: CHEMBL2311103, SureCN3273165, ORG2058, KST-1A3116, AC1Q6OBA, ...
 
 
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High impact information on ORG2058

 

Biological context of ORG2058

 

Anatomical context of ORG2058

 

Associations of ORG2058 with other chemical compounds

 

Gene context of ORG2058

References

  1. 17 beta-hydroxysteroid dehydrogenase gene expression in human breast cancer cells: regulation of expression by a progestin. Poutanen, M., Moncharmont, B., Vihko, R. Cancer Res. (1992) [Pubmed]
  2. Ligand-activated progesterone receptor isoform hPR-A is a stronger transactivator than hPR-B for the expression of IGFBP-1 (insulin-like growth factor binding protein-1) in human endometrial stromal cells. Gao, J., Mazella, J., Tang, M., Tseng, L. Mol. Endocrinol. (2000) [Pubmed]
  3. Progestin radiopharmaceuticals labeled with technetium and rhenium: synthesis, binding affinity, and in vivo distribution of a new progestin N2S2-metal conjugate. O'Neil, J.P., Carlson, K.E., Anderson, C.J., Welch, M.J., Katzenellenbogen, J.A. Bioconjug. Chem. (1994) [Pubmed]
  4. The relationship between affinity of progestins and antiprogestins for the progesterone receptor in breast cancer cells (ZR-PR-LT) and ability to down-regulate the receptor: evidence for heterospecific receptor modulation via the glucocorticoid receptor. van den Berg, H.W., Lynch, M., Martin, J.H. Eur. J. Cancer (1993) [Pubmed]
  5. Effect of tibolone (Org OD14) and its metabolites on aromatase and estrone sulfatase activity in human breast adipose stromal cells and in MCF-7 and T47D breast cancer cells. van de Ven, J., Donker, G.H., Sprong, M., Blankenstein, M.A., Thijssen, J.H. J. Steroid Biochem. Mol. Biol. (2002) [Pubmed]
  6. The progesterone receptor. Biological effects of progestins and antiprogestins. Savouret, J.F., Chauchereau, A., Misrahi, M., Lescop, P., Mantel, A., Bailly, A., Milgrom, E. Hum. Reprod. (1994) [Pubmed]
  7. Inhibition by nomegestrol acetate and other synthetic progestins on proliferation and progesterone receptor content of T47-D human breast cancer cells. Botella, J., Duranti, E., Duc, I., Cognet, A.M., Delansorne, R., Paris, J. J. Steroid Biochem. Mol. Biol. (1994) [Pubmed]
  8. Pre-clinical and clinical treatment of breast cancer with antiprogestins. Klijn, J.G., Setyono-Han, B., Sander, H.J., Lamberts, S.W., de Jong, F.H., Deckers, G.H., Foekens, J.A. Hum. Reprod. (1994) [Pubmed]
  9. High-performance and ion-exchange chromatography and chromatofocusing of the human uterine progesterone receptor: its application to the identification of 21-[3H]dehydro Org 2058-labelled receptor. Heubner, A., Manz, B., Grill, H.J., Pollow, K. J. Chromatogr. (1984) [Pubmed]
  10. Selectivity in progesterone and androgen receptor binding of progestagens used in oral contraceptives. Kloosterboer, H.J., Vonk-Noordegraaf, C.A., Turpijn, E.W. Contraception. (1988) [Pubmed]
  11. New iodinated progestins as potential ligands for progesterone receptor imaging in breast cancer. Part 1: Synthesis and in vitro pharmacological characterization. van den Bos, J.C., Rijks, L.J., van Doremalen, P.A., de Bruin, K., Janssen, A.G., van Royen, E.A. Nucl. Med. Biol. (1998) [Pubmed]
  12. Progesterone analogues similarly modulate endometrial matrix metalloproteinase-1 and matrix metalloproteinase-3 and their inhibitor in a model for long-term contraceptive effects. Hampton, A.L., Nie, G., Salamonsen, L.A. Mol. Hum. Reprod. (1999) [Pubmed]
 
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