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Chemical Compound Review

nandrolone     (8R,9S,10R,13S,14S,17S)-17- hydroxy-13...

Synonyms: decadura, Nadrolone, Nandrolon, Estrenolone, Nortestosterone, ...
 
 
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Disease relevance of Norandrostenolone

 

High impact information on Norandrostenolone

 

Biological context of Norandrostenolone

 

Anatomical context of Norandrostenolone

 

Associations of Norandrostenolone with other chemical compounds

  • In contrast, when 19-nortestosterone (NT) is 5 alpha-reduced, its affinity for AR decreases, resulting in a decrease in its androgenic potency [16].
  • Young male adult Wistar rats were treated over a 25-day period with either oil (CON, n = 8), nandrolone (nortestosterone decanoate, NAN, n = 8), nandrolone combined with endurance exercise (treadmill running, NAN+EXE, n = 8), or were castrated (CAS, n = 8) [17].
  • In all samples the identification of NT and DES was confirmed by high resolution gas chromatography-mass spectrometry (GCMS) [18].
  • Groups of female CBA-mice were given 90Sr (14.8 kBq/g-0.4muCi/g--bodyweight) alone or in combination with polyestrodiolphosphate, methylprednisolone or nortestosterone, respectively [19].
  • Cell incubations with norandrostenedione and nortestosterone gave rise to large amounts of estrone sulfate in the medium as determined directly by a specific radioimmunoassay (RIA) [20].
 

Gene context of Norandrostenolone

  • The nortestosterone derivatives also showed AR binding, the relative binding affinities ranging from 4.3 to 17.0% as compared with 5alphaDHT [21].
  • We conclude that the in vitro binding properties of all four 17alpha-iodovinyl nortestosterone derivatives warrant evaluation of the distribution characteristics of their 123I-labelled analogues to determine their usefulness as PR imaging agents [21].
 

Analytical, diagnostic and therapeutic context of Norandrostenolone

References

  1. 11beta-alkyl-Delta9-19-nortestosterone derivatives: high-affinity ligands and potent partial agonists of the androgen receptor. Muddana, S.S., Price, A.M., MacBride, M.M., Peterson, B.R. J. Med. Chem. (2004) [Pubmed]
  2. Changes in lipoproteins with various sex steroids. Teran, A.Z., Greenblatt, R.B., Chaddha, J.S. Obstet. Gynecol. Clin. North Am. (1987) [Pubmed]
  3. Azoospermia associated with a mutation in the ligand-binding domain of an androgen receptor displaying normal ligand binding, but defective trans-activation. Wang, Q., Ghadessy, F.J., Trounson, A., de Kretser, D., McLachlan, R., Ng, S.C., Yong, E.L. J. Clin. Endocrinol. Metab. (1998) [Pubmed]
  4. A direct, low-temperature 1-H, 13-C, and 19-F nuclear magnetic resonance study of boron trifluoride complexes with stigmasterol, androstanolone, androsterone, testosterone, nortestosterone, androstenedione, and progesterone-1,2. Fratiello, A., Stover, C.S. J. Org. Chem. (1975) [Pubmed]
  5. Synthesis of the 7alpha-cyano-(17alpha,20E/Z)-[125I]iodovinyl-19-nortestosterones: potential radioligands for androgen and progesterone receptors. Ali, H., Rousseau, J., Ahmed, N., Guertin, V., Hochberg, R.B., van Lier, J.E. Steroids (2003) [Pubmed]
  6. Validity of radioimmunological methods for determining free testosterone in serum. Gruschke, A., Kuhl, H. Fertil. Steril. (2001) [Pubmed]
  7. Residues of nortestosterone esters at injection sites. Part 2. Behavioural effects. McEvoy, J.D., McVeigh, C.E., McCaughey, W.J. The Analyst. (1998) [Pubmed]
  8. Residues of nortestosterone esters at injection sites. Part 1. Oral bioavailability. McEvoy, J.D., McVeigh, C.E., McCaughey, W.J. The Analyst. (1998) [Pubmed]
  9. Evidence for the presence of endogenous 19-nortestosterone in the cow peripartum and in the neonatal calf. Meyer, H.H., Falckenberg, D., Janowski, T., Rapp, M., Rösel, E.F., van Look, L., Karg, H. Acta Endocrinol. (1992) [Pubmed]
  10. Comparison of the efficiences of enzymatic and chemical hydrolysis of (nortestosterone and diethylstilboestrol) glucuronides in bovine urine. Cooper, J., Currie, W., Elliott, C.T. J. Chromatogr. B Biomed. Sci. Appl. (2001) [Pubmed]
  11. Effect of chronic intravenous injection of steroid hormones on body weight and composition of female rats. Lobo, M.J., Remesar, X., Alemany, M. Biochem. Mol. Biol. Int. (1993) [Pubmed]
  12. Effect of embryonic 19-nortestosterone treatment and surgical bursectomy on plasma concentrations of reproductive hormones, on inhibin content in adrenals and gonads and on the histological appearance of the gonads in the young chicken. Bruggeman, V., Room, G., Vanmontfort, D., Verhoeven, G., Decuypere, E. Gen. Comp. Endocrinol. (2003) [Pubmed]
  13. Aromatization of testosterone and 19-nortestosterone by a single enzyme from equine testicular microsomes. Differences from human placental aromatase. Silberzahn, P., Gaillard, J.L., Quincey, D., Dintinger, T., Al-Timimi, I. J. Steroid Biochem. (1988) [Pubmed]
  14. Different binding of testosterone, 19-nortestosterone and their 5 alpha-reduced derivatives to the androgen receptor of the rat seminal vesicle: a step toward the understanding of the anabolic action of nortesterone. Tóth, M., Zakár, T. Endokrinologie. (1982) [Pubmed]
  15. Evaluation of human hepatocyte incubation as a new tool for metabolism study of androstenedione and norandrostenedione in a doping control perspective. Lévesque, J.F., Gaudreault, M., Houle, R., Chauret, N. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. (2002) [Pubmed]
  16. Different patterns of metabolism determine the relative anabolic activity of 19-norandrogens. Sundaram, K., Kumar, N., Monder, C., Bardin, C.W. J. Steroid Biochem. Mol. Biol. (1995) [Pubmed]
  17. Effect of anabolic/androgenic steroids on myosin heavy chain expression in hindlimb muscles of male rats. Noirez, P., Ferry, A. European journal of applied physiology. (2000) [Pubmed]
  18. Monitoring and identification of residues of anabolic preparations in slaughtered cattle by HPLC with diode array detection. Jansen, E.H., van Blitterswijk, H., Stephany, R.W. The Veterinary quarterly. (1984) [Pubmed]
  19. Influence of steroid hormones on the carcinogenicity of 90Sr. Nilsson, A., Broomé-Karlsson, A. Acta radiologica: therapy, physics, biology. (1976) [Pubmed]
  20. Aromatization of 19-norandrogens by porcine Leydig cells. Raeside, J.I., Renaud, R.L., Friendship, R.M. J. Steroid Biochem. (1989) [Pubmed]
  21. New iodinated progestins as potential ligands for progesterone receptor imaging in breast cancer. Part 1: Synthesis and in vitro pharmacological characterization. van den Bos, J.C., Rijks, L.J., van Doremalen, P.A., de Bruin, K., Janssen, A.G., van Royen, E.A. Nucl. Med. Biol. (1998) [Pubmed]
  22. Radioimmunoassay of nortestosterone and related steroids. Hampl, R., Picha, J., Chundela, B., Stárka, L. J. Clin. Chem. Clin. Biochem. (1979) [Pubmed]
  23. The metabolism of orally ingested 19-nor-4-androstene-3,17-dione and 19-nor-4-androstene-3,17-diol in healthy, resistance-trained men. Colker, C.M., Antonio, J., Kalman, D. Journal of strength and conditioning research / National Strength & Conditioning Association. (2001) [Pubmed]
  24. Development of a chemiluminescent immunoassay for 19-nortestosterone (nandrolone). Jansen, E.H., Zomer, G., van den Berg, R.H., Stephany, R.W. The Veterinary quarterly. (1984) [Pubmed]
  25. Metabolism of 19 nortestosterone-14C associated with oestradiol in mice and calves. Rico, A.G., Benard, P., Braun, J.P., Burgat-Sacaze, V. Ann. Rech. Vet. (1977) [Pubmed]
  26. A progesterone receptor affinity chromatography reagent: 17 alpha-hexynyl nortestosterone sepharose. Salman, M., Ruiz, A.A., Stotter, P.L., Chamness, G.C. J. Steroid Biochem. (1987) [Pubmed]
 
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