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Gene Review

ADA  -  adenosine deaminase

Canis lupus familiaris

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Disease relevance of ADA

  • However, ADA did not inhibit dilation induced by gradual stenoses (10.6 +/- 1.4, 24.2 +/- 4.3, 17.5 +/- 6.9%, at each PP, NS vs. vehicle group).(ABSTRACT TRUNCATED AT 250 WORDS)[1]
  • Under control, pre-ADA conditions, hypoxia (arterial PO2 19 +/- 2 mmHg) caused left anterior descending (LAD) coronary blood flow to increase from 100 +/- 12 to 382 +/- 47 ml X min-1 X 100 g-1 (+282%) [2].
  • The NE-induced hyperemia and the increase in MVo2 were again decreased by ADA [3].
  • ADA also attenuated significantly the coronary vasodilatory response to exogenous adenosine and to 20-s ischemia [2].
  • Efficacy of ADA was also evaluated by examining its effect on the coronary responses to exogenous adenosine and to 20-s myocardial ischemia [2].

High impact information on ADA


Chemical compound and disease context of ADA


Biological context of ADA

  • EHNA (3--10 microM in blood) did not inhibit stimulated lipolysis in vivo possibly because of the low ADA activity in fat cells [11].
  • ADA completely blocked the norepinephrine-induced vasodilation (n = 6) [12].
  • In eight dogs, the NE-induced hyperemia was decreased from +150 to +67%, the change in myocardial oxygen consumption (MVo2) was attenuated from +177 to +101% by ADA, and the increase in HR was reduced from +28 to +16% [3].
  • Infusion of ADA confirmed the specificity of the response by blocking the metabolic effect of exogenously infused ADO [13].
  • In unstimulated tissues, ADA (n = 7) significantly increased vascular resistance and significantly decreased glucose uptake compared with the effects of a control (boiled deaminase, n = 6) infusion [12].

Anatomical context of ADA

  • Blood flow in regions of myocardium supplied by the nonstenotic left anterior descending coronary artery were unchanged following ADA plus 8-PT.(ABSTRACT TRUNCATED AT 250 WORDS)[14]
  • CONCLUSIONS: Although inhibition of adenosine deaminase effectively enhances ISF adenosine before and during ischaemia, the increase before ischaemia does not "precondition" the myocardium, nor does the augmentation of adenosine during and after ischaemia attenuate necrosis in this model of ischaemia [15].
  • The heart was paced (3 V, 0.2 ms and a suitable frequency) via two electrodes attached to the right atrium from 109 +/- 7.3 to 170 +/- 9.8 beats min-4 (means +/- S.E.M.) for 3-4 min, first during an infusion of the solvent, and then during an infusion of a solution of adenosine deaminase (5 U kg-1 min-1) into the circuit [16].
  • Pharmacokinetic studies showed pentostatin significantly inhibited adenosine deaminase in canine lymphocytes [17].
  • These in vivo experiments clearly demonstrate that alpha-2 adrenoceptor stimulation is able to inhibit beta-stimulated or theophylline plus adenosine deaminase-promoted lipid mobilization from bone marrow fat stores [18].

Associations of ADA with chemical compounds


Analytical, diagnostic and therapeutic context of ADA


  1. Role of adenosine in vasodilation of epimyocardial coronary microvessels during reduction in perfusion pressure. Komaru, T., Lamping, K.G., Dellsperger, K.C. J. Cardiovasc. Pharmacol. (1994) [Pubmed]
  2. Adenosine deaminase attenuates canine coronary vasodilation during systemic hypoxia. Merrill, G.F., Downey, H.F., Jones, C.E. Am. J. Physiol. (1986) [Pubmed]
  3. Adenosine deaminase attenuates norepinephrine-induced coronary functional hyperemia. Downey, H.F., Merrill, G.F., Yonekura, S., Watanabe, N., Jones, C.E. Am. J. Physiol. (1988) [Pubmed]
  4. Canine cyclic hematopoiesis is associated with abnormal purine and pyrimidine metabolism. Osborne, W.R., Hammond, W.P., Dale, D.C. J. Clin. Invest. (1983) [Pubmed]
  5. Quantitative relation between interstitial adenosine concentration and coronary blood flow. Stepp, D.W., Van Bibber, R., Kroll, K., Feigl, E.O. Circ. Res. (1996) [Pubmed]
  6. Role of adenosine in coronary blood flow regulation after reductions in perfusion pressure. Dole, W.P., Yamada, N., Bishop, V.S., Olsson, R.A. Circ. Res. (1985) [Pubmed]
  7. Effect of adenosine deaminase inhibitors on myocardial reactive hyperaemia following brief coronary occlusions. Saito, D., Abe, Y., Tani, H., Takeda, K., Hyodo, T., Nakatsu, T., Ueeda, M., Kusachi, S. Cardiovasc. Res. (1985) [Pubmed]
  8. Adenosine deaminase and BW A1433U attenuate hypoxia-induced ventricular ectopy. Leone, R.J., Friedrichs, G.S., Merrill, G.F. J. Appl. Physiol. (1993) [Pubmed]
  9. Effect of adenosine deaminase inhibition with pentostatin on myocardial stunning in dogs. McClanahan, T.B., Ignasiak, D.P., Martin, B.J., Mertz, T.E., Gallagher, K.P. Basic Res. Cardiol. (1995) [Pubmed]
  10. Relative participation of adenosine and endothelium derived mediators in coronary reactive hyperemia in the dog. Macho, P., Domenech, R., Penna, M. Biol. Res. (1995) [Pubmed]
  11. The antilipolytic effect of endogenous and exogenous adenosine in canine adipose tissue in situ. Sollevi, A., Fredholm, B.B. Acta Physiol. Scand. (1981) [Pubmed]
  12. Adenosine regulates blood flow and glucose uptake in adipose tissue of dogs. Martin, S.E., Bockman, E.L. Am. J. Physiol. (1986) [Pubmed]
  13. Adenosine potentiates insulin-stimulated myocardial glucose uptake in vivo. Law, W.R., Raymond, R.M. Am. J. Physiol. (1988) [Pubmed]
  14. Inhibition of adenosine-mediated coronary vasodilation exacerbates myocardial ischemia during exercise. Laxson, D.D., Homans, D.C., Bache, R.J. Am. J. Physiol. (1993) [Pubmed]
  15. Adenosine deaminase inhibition augments interstitial adenosine but does not attenuate myocardial infarction. Silva, P.H., Dillon, D., Van Wylen, D.G. Cardiovasc. Res. (1995) [Pubmed]
  16. The role of adenosine in functional hyperaemia in the coronary circulation of anaesthetized dogs. Karim, F., Goonewardene, I.P. J. Physiol. (Lond.) (1996) [Pubmed]
  17. Prolonged allogeneic marrow engraftment following nonmyeloablative conditioning using 100 cGy total body irradiation and pentostatin before and pharmacological immunosuppression after transplantation. Panse, J.P., Storb, R., Storer, B., Santos, E.B., Wentzel, C., Sandmaier, B.M. Transplantation (2005) [Pubmed]
  18. Interplay of alpha-2 and beta adrenoceptors in the control of free fatty acid release from bone marrow adipose tissue. Tran, M.A., Lac, D.T., Berlan, M., Lafontan, M. J. Pharmacol. Exp. Ther. (1984) [Pubmed]
  19. Evidence from bioassay studies indicating a role for adenosine in cardiac ischemic and hypoxic dilation in the dog. Scott, J.B., Chen, W.T., Swindall, B.T., Dabney, J.M., Haddy, F.J. Circ. Res. (1979) [Pubmed]
  20. Role of adenosine in postischemic dysfunction of coronary innervation. Pettersen, M.D., Abe, T., Morgan, D.A., Gutterman, D.D. Circ. Res. (1995) [Pubmed]
  21. Endogenous adenosine and coronary vasoconstriction in hypoperfused myocardium during exercise. Duncker, D.J., Laxson, D.D., Lindstrom, P., Bache, R.J. Cardiovasc. Res. (1993) [Pubmed]
  22. Adenosine deaminase attenuates canine coronary vasodilatation during regional non-ischaemic myocardial hypoxia. Merrill, G.F., Downey, H.F., Yonekura, S., Watanabe, N., Jones, C.E. Cardiovasc. Res. (1988) [Pubmed]
  23. Preservation of global cardiac function in the rabbit following protracted ischemia/reperfusion using monophosphoryl lipid A (MLA). Zhao, L., Kirsch, C.C., Hagen, S.R., Elliott, G.T. J. Mol. Cell. Cardiol. (1996) [Pubmed]
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