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Chemical Compound Review

Muristerone     (2S,3R,5S,9R,10R,11R,13R,14S,1 7S)-17-[(2R...

Synonyms: muristerone a, AG-F-36768, CHEMBL2087139, CTK8G1208, AC1L3U7D, ...
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Disease relevance of muristerone a

  • In order to study the function of p21waf in a p53-deficient environment, we established an inducible expression of p21waf in the p53-null lung cancer cell line H1299, based on the muristerone-regulated system [1].

High impact information on muristerone a


Biological context of muristerone a


Anatomical context of muristerone a


Associations of muristerone a with other chemical compounds

  • Two Drosophila imaginal disc cell lines, C18+ (sensitive to 20-hydroxyecdysone, 20HE) and C18R (resistant to 20HE) were exposed to the ecdysteroid agonists RH5849 and RH5992 and the ecdysteroids inokosterone, makisterone A and muristerone A [14].
  • Functionally active NMDA receptors were also detected in EcR/rNR1a2B cells after MuA induction [15].
  • Each of the EcR variants responded to the synthetic ecdysteroid, muristerone A (murA), but a maximal response to 20-hydroxyecdysone (20E) was achieved only for specific EcR combinations with its heterodimeric partner [16].
  • The two ecdysone analogs, muristerone A and ponasterone A, induced D2L receptor expression dose-dependently from 120 (non-induced) to 2000 fmol/mg protein which is similar to physiological D2 receptor density in dopaminergic brain regions [17].

Gene context of muristerone a

  • To check inducibility, NR2A subunit expression in D5/H3 cells treated with the inducing agent muristerone A (MuA) was compared with that in non-induced cells [18].
  • The mRNA level of the NR2B subunits in EcR/rNRa2B cells was dependent on the concentration of the ecdysone analogue inducing agent, muristerone A (MuA) [15].
  • Similarly, two transcription-regulation systems, muristerone-regulated and Tet-On, were tested to control the expression of CC8 [19].
  • We have developed a human kidney embryonic cell line (EcRG293) that expresses high-affinity GnRH receptor under the control of an inducible promoter activated by muristerone A [6].
  • Addition of muristerone A induced a dose-dependent decrease in the viability of cells transfected with wild-type BAX, but this loss of viability was inhibited in cells transfected with BAX mutants [5].

Analytical, diagnostic and therapeutic context of muristerone a


  1. Induced p21waf expression in H1299 cell line promotes cell senescence and protects against cytotoxic effect of radiation and doxorubicin. Wang, Y., Blandino, G., Givol, D. Oncogene (1999) [Pubmed]
  2. The interferon-inducible nucleolar p204 protein binds the ribosomal RNA-specific UBF1 transcription factor and inhibits ribosomal RNA transcription. Liu, C.J., Wang, H., Lengyel, P. EMBO J. (1999) [Pubmed]
  3. Agonists of an ecdysone-inducible mammalian expression system inhibit Fas Ligand- and TRAIL-induced apoptosis in the human colon carcinoma cell line RKO. Oehme, I., Bösser, S., Zörnig, M. Cell Death Differ. (2006) [Pubmed]
  4. Ectopic expression of cyclin D1 impairs the proliferation and enhances the apoptosis of a murine lymphoid cell line. Duquesne, F., Florent, M., Roué, G., Troussard, X., Sola, B. Cell Death Differ. (2001) [Pubmed]
  5. Impairment of the proapoptotic activity of Bax by missense mutations found in gastrointestinal cancers. Gil, J., Yamamoto, H., Zapata, J.M., Reed, J.C., Perucho, M. Cancer Res. (1999) [Pubmed]
  6. Inhibition of growth and proliferation of EcRG293 cell line expressing high-affinity gonadotropin-releasing hormone (GnRH) receptor under the control of an inducible promoter by GnRH agonist (D-Lys6)GnRH and antagonist (Antide). Kakar, S.S. Cancer Res. (1998) [Pubmed]
  7. Induction of human high K(M) 5'-nucleotidase in cultured 293 cells. Gazziola, C., Moras, M., Ferraro, P., Gallinaro, L., Verin, R., Rampazzo, C., Reichard, P., Bianchi, V. Exp. Cell Res. (1999) [Pubmed]
  8. Low amounts of the DNA repair XPA protein are sufficient to recover UV-resistance. Muotri, A.R., Marchetto, M.C., Suzuki, M.F., Okazaki, K., Lotfi, C.F., Brumatti, G., Amarante-Mendes, G.P., Menck, C.F. Carcinogenesis (2002) [Pubmed]
  9. Inducible expression of a degradation-resistant form of p27Kip1 causes growth arrest and apoptosis in breast cancer cells. Zhang, Q., Tian, L., Mansouri, A., Korapati, A.L., Johnson, T.J., Claret, F.X. FEBS Lett. (2005) [Pubmed]
  10. Drosophila ecdysone receptor functions as a constitutive activator in yeast. Dela Cruz, F., Mak, P. J. Steroid Biochem. Mol. Biol. (1997) [Pubmed]
  11. The overexpression of Bax produces cell death upon induction of the mitochondrial permeability transition. Pastorino, J.G., Chen, S.T., Tafani, M., Snyder, J.W., Farber, J.L. J. Biol. Chem. (1998) [Pubmed]
  12. Muristerone A-induced nerve growth factor release from genetically engineered human dermal fibroblasts for peripheral nerve tissue engineering. Patrick, C.W., Zheng, B., Wu, X., Gurtner, G., Barlow, M., Koutz, C., Chang, D., Schmidt, M., Evans, G.R. Tissue engineering. (2001) [Pubmed]
  13. Strict control of telomerase activation using Cre-mediated inversion. Ungrin, M.D., Harrington, L. BMC Biotechnol. (2006) [Pubmed]
  14. The effects of several ecdysteroids and ecdysteroid agonists on two Drosophila imaginal disc cell lines. Cottam, D.M., Milner, M.J. Cell. Mol. Life Sci. (1997) [Pubmed]
  15. Inducible expression and pharmacology of recombinant NMDA receptors, composed of rat NR1a/NR2B subunits. Nagy, J., Boros, A., Dezso, P., Kolok, S., Fodor, L. Neurochem. Int. (2003) [Pubmed]
  16. Juvenile hormone potentiates ecdysone receptor-dependent transcription in a mammalian cell culture system. Henrich, V.C., Burns, E., Yelverton, D.P., Christensen, E., Weinberger, C. Insect Biochem. Mol. Biol. (2003) [Pubmed]
  17. Basal signaling activity of human dopamine D2L receptor demonstrated with an ecdysone-inducible mammalian expression system. Choi, D.S., Wang, D., Tolbert, L., Sadée, W. J. Neurosci. Methods (2000) [Pubmed]
  18. Inducible expression and pharmacological characterization of recombinant rat NR1a/NR2A NMDA receptors. Kurkó, D., Dezso, P., Boros, A., Kolok, S., Fodor, L., Nagy, J., Szombathelyi, Z. Neurochem. Int. (2005) [Pubmed]
  19. Development of an inducible suicide gene system based on human caspase 8. Carlotti, F., Zaldumbide, A., Martin, P., Boulukos, K.E., Hoeben, R.C., Pognonec, P. Cancer Gene Ther. (2005) [Pubmed]
  20. Titrating the expression of a Gi protein-coupled receptor using an ecdysone-inducible system in CHO-K1 cells. Cole, S.L., Schindler, M., Sellers, L.A., Humphrey, P.P. Recept. Channels (2001) [Pubmed]
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