Disease relevance of Acetylputrescine

• Putrescine N-acetyltransferase in Onchocerca volvulus and Ascaris suum, an enzyme which is involved in polyamine degradation and release of N-acetylputrescine [1].

High impact information on Acetylputrescine

• Formulation of N-acetylputrescine and N1-acetylspermidine in cultured human lymphocytes [2].
• In vitro synthesis of peptidoglycan precursors modified with N-acetylputrescine by Cyanophora paradoxa cyanelle envelope membranes [3].
• The photosynthetic organelles (cyanelles) of the protist Cyanophora paradoxa are surrounded by a peptidoglycan wall, modified through amidation with N-acetylputrescine [3].
• The Bz.SSAO enzyme which is present in the rat mesenteric artery is not only able to oxidize histamine, but also methylamine, acetylputrescine and some methylated forms of histamine including 1,4-methylhistamine [4].
• Acetylputrescine was not detected in the epididymis, while acetylpolyamines were detected at much lower concentrations than polyamines [5].

Biological context of Acetylputrescine

• The enzyme had an optimal pH around 8.0 with acetylputrescine as substrate and showed broad substrate specificity and high affinity towards various acetylpolyamines, such as acetylputrescine, acetylcadaverine, acetylspermidine, and acetylspermine [6].

Associations of Acetylputrescine with other chemical compounds

• 2. Enzymes from mice, rabbits and pigs shared similar biochemical characteristics: they exerted histaminase activity, oxidized methylamine and acetylputrescine and were completely blocked by carbonyl reagents and by 3,5-ethoxy-4-aminomethylpyridyne (B24), in a dose-dependent fashion [7].
• Based on combined data from plasma desorption mass spectrometry, tandem mass spectrometry, accurate mass measurement and amino acid analysis of the acid hydrolysate after derivatization with o-phthaldialdehyde by high-performance liquid chromatography we could establish the structure of the modification as N-acetylputrescine [8].

Analytical, diagnostic and therapeutic context of Acetylputrescine

• They were identified by paper chromatography and t.l.c. Acetylputrescine was also identified by mass spectrometry [2].
• High-resolution fast atom bombardment-mass spectrometry and amino acid analysis revealed N-acetylputrescine to be the substituent (E. Pittenauer, E. R. Schmid, G. Allmaier, B. Pfanzagl, W. Löffelhardt, C. Quintela, M. A. de Pedro, and W. Stanek, Biol. Mass Spectrom. 22:524-536, 1993) [9].

References