The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

AOC1  -  amine oxidase, copper containing 1

Homo sapiens

Synonyms: ABP, ABP1, Amiloride-binding protein 1, Amine oxidase copper domain-containing protein 1, DAO, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of ABP1


Psychiatry related information on ABP1

  • Large bowel tumors and diamine oxidase (DAO) activity in patients: a new approach for risk group identification [6].
  • The 12q peak overlaps with a region previously implicated by linkage studies of unipolar and bipolar disorders and contains a gene, DAO, that has been associated with both bipolar disorder and schizophrenia [7].
  • METHODS: Using post-hoc analyses from the Baseline Double Exposure cohort study, alcohol consumption and gender were examined as to their association with ambulatory BP (ABP) in participants with normal or elevated and untreated BP [8].
  • Individual differences were found between pharmacy BP and daytime ABP: +4.6+/-14.8; +2.9+/-8 [9].
  • CONCLUSIONS: Perceived racism and anger inhibition are independently related to higher ABP [10].

High impact information on ABP1

  • Clearly some like relaxin and inhibin function as important hormones, and ABP, for example, probably functions importantly in transporting testosterone down the tubule [11].
  • Variable content of histaminase, L-dopa decarboxylase and calcitonin in small-cell carcinoma of the lung. Biologic and clinical implications [12].
  • Histaminase was increased in six of six primary tumors (three to 14,000 times), L-dopa decarboxylase in four of six (six to 30 times), and calcitonin in one of one (eight times) over levels in adjacent lung [12].
  • The data support the proposed embryologic relation between small-cell lung carcinoma and medullary thyroid carcinoma, and further associate histaminase with some neural crest tumors [13].
  • The enzyme in plasma and in tumor behaved as classic histaminase in substrate specificity, and in response to inhibitors [13].

Chemical compound and disease context of ABP1


Biological context of ABP1


Anatomical context of ABP1

  • The mRNA was expressed in 293-S and NIH 3T3 cells, yielding a glycoprotein (i) that binds amiloride and amiloride analogs with affinities similar to the amiloride receptor associated with the apical Na+ channel in pig kidney membranes and (ii) that is immunoprecipitated with monoclonal antibodies raised against pig kidney amiloride-binding protein [18].
  • Receptor-bound DAO is retained under mildly acidic conditions characteristic of early to mid endocytic intracellular compartments and thus could recycle to the plasma membrane intact after internalization [21].
  • A diamine oxidase released from human neutrophil granules by activation with Ca2+ ionophore binds pulmonary and systemic endothelial cell and fibroblast diamine oxidase receptors and, thereby, participates in histamine degradative uptake [22].
  • Histamine degradative uptake by cultured human pulmonary vascular endothelial cells utilizes an inflammatory cell diamine oxidase [22].
  • Genomic clones covering the entire sequence of the gene encoding human D-amino-acid oxidase (DAO) (EC, one of the principal and characteristic flavoenzymes of peroxisomes, were isolated from human placental genomic libraries with the aid of a previously cloned cDNA for human DAO as a probe [20].

Associations of ABP1 with chemical compounds


Enzymatic interactions of ABP1


Regulatory relationships of ABP1


Other interactions of ABP1

  • The mean values of histamine content and activities of HDC, HMT and histaminase of human nasal mucosa were 137.3 nmol/g wet weight, 26.3 fmol/min/mg protein, 26.4 pmol/min/mg protein and 0.5 pmol/min/mg protein, respectively [3].
  • We present a comparative map of the Lyp region in rat and human, assigning the gene to a 1.3-Mb segment between RNY3 and ABP1 at 7q35 [26].
  • The prognostic and biological significance of cellular heterogeneity in medullary thyroid carcinoma: a study of calcitonin, L-dopa decarboxylase, and histaminase [27].
  • Serum concentrations of albumin and retinol-binding protein (RBP) as nutritional parameters and diamine oxidase (DAO) activity, an enzyme reflecting mucosal integrity, were measured preoperatively and 1, 4, 7, and 14 days postoperatively and compared between the 2 groups [28].
  • Clinic BP, plasma cortisol and plasma NPY (both analysed by radio-immunoassay) were obtained at 0800 h and 24h ambulatory BP (ABP) was performed [29].

Analytical, diagnostic and therapeutic context of ABP1


  1. Severity of ulcerative colitis is associated with a polymorphism at diamine oxidase gene but not at histamine N-methyltransferase gene. García-Martin, E., Mendoza, J.L., Martínez, C., Taxonera, C., Urcelay, E., Ladero, J.M., de la Concha, E.G., Díaz-Rubio, M., Agúndez, J.A. World J. Gastroenterol. (2006) [Pubmed]
  2. Localization of the gene for amiloride binding protein on chromosome 7 and RFLP analysis in cystic fibrosis families. Barbry, P., Simon-Bouy, B., Mattéi, M.G., Le Guern, E., Jaume-Roig, B., Chassande, O., Ullrich, A., Lazdunski, M. Hum. Genet. (1990) [Pubmed]
  3. Histamine content, synthesis and degradation in human nasal mucosa. Abe, Y., Ogino, S., Irifune, M., Imamura, I., Fukui, H., Wada, H., Matsunaga, T. Clin. Exp. Allergy (1993) [Pubmed]
  4. Wine and headache. Jarisch, R., Wantke, F. Int. Arch. Allergy Immunol. (1996) [Pubmed]
  5. Cervical intraepithelial neoplasia is associated with increased polyamine oxidase and diamine oxidase concentrations in cervical mucus. Rogers, M.S., Yim, S.F., Li, K.C., Wang, C.C., Arumanayagam, M. Gynecol. Oncol. (2002) [Pubmed]
  6. Large bowel tumors and diamine oxidase (DAO) activity in patients: a new approach for risk group identification. Mennigen, R., Kusche, J., Krakamp, B., Elbers, A., Amoei, B., Kessebohm, M., Sommer, H. Agents Actions (1988) [Pubmed]
  7. Whole genome linkage scan of recurrent depressive disorder from the depression network study. McGuffin, P., Knight, J., Breen, G., Brewster, S., Boyd, P.R., Craddock, N., Gill, M., Korszun, A., Maier, W., Middleton, L., Mors, O., Owen, M.J., Perry, J., Preisig, M., Reich, T., Rice, J., Rietschel, M., Jones, L., Sham, P., Farmer, A.E. Hum. Mol. Genet. (2005) [Pubmed]
  8. The effect of alcohol and gender on ambulatory blood pressure: results from the Baseline Double Exposure study. Tobe, S.W., Soberman, H., Kiss, A., Perkins, N., Baker, B. Am. J. Hypertens. (2006) [Pubmed]
  9. White coat effect and white coat hypertension in community pharmacy practice. Botomino, A., Martina, B., Ruf, D., Bruppacher, R., Hersberger, K.E. Blood pressure monitoring. (2005) [Pubmed]
  10. Effects of perceived racism and anger inhibition on ambulatory blood pressure in African Americans. Steffen, P.R., McNeilly, M., Anderson, N., Sherwood, A. Psychosomatic medicine. (2003) [Pubmed]
  11. Nonsteroidal signals originating in the gonads. Ackland, J.F., Schwartz, N.B., Mayo, K.E., Dodson, R.E. Physiol. Rev. (1992) [Pubmed]
  12. Variable content of histaminase, L-dopa decarboxylase and calcitonin in small-cell carcinoma of the lung. Biologic and clinical implications. Baylin, S.B., Weisburger, W.R., Eggleston, J.C., Mendelsohn, G., Beaven, M.A., Abeloff, M.D., Ettinger, D.S. N. Engl. J. Med. (1978) [Pubmed]
  13. Elevated histaminase (diamine oxidase) activity in small-cell carcinoma of the lung. Baylin, S.B., Abeloff, M.D., Wieman, K.C., Tomford, J.W., Ettinger, D.S. N. Engl. J. Med. (1975) [Pubmed]
  14. Diamine oxidase (histaminase) in chronic renal disease and its inhibition in vitro by methylguanidine. Gäng, V., Berneburg, H., Hennemann, H., Hevendehl, G. Clin. Nephrol. (1976) [Pubmed]
  15. Regulation of synthesis and turnover of maize auxin-binding protein and observations on its passage to the plasma membrane: comparisons to maize immunoglobulin-binding protein cognate. Oliver, S.C., Venis, M.A., Freedman, R.B., Napier, R.M. Planta (1995) [Pubmed]
  16. Age-related abnormalities of circulating polyamines and diamine oxidase activity in cystic fibrosis heterozygotes and homozygotes. Baylin, S.B., Rosenstein, B.J., Marton, L.J., Lockwood, D.H. Pediatr. Res. (1980) [Pubmed]
  17. Methylamine oxidase from Arthrobacter P1 as a prototype of eukaryotic plasma amine oxidase and diamine oxidase. McIntire, W.S., Dooley, D.M., McGuirl, M.A., Cote, C.E., Bates, J.L. J. Neural Transm. Suppl. (1990) [Pubmed]
  18. Human kidney amiloride-binding protein: cDNA structure and functional expression. Barbry, P., Champe, M., Chassande, O., Munemitsu, S., Champigny, G., Lingueglia, E., Maes, P., Frelin, C., Tartar, A., Ullrich, A. Proc. Natl. Acad. Sci. U.S.A. (1990) [Pubmed]
  19. The human gene for diamine oxidase, an amiloride binding protein. Molecular cloning, sequencing, and characterization of the promoter. Chassande, O., Renard, S., Barbry, P., Lazdunski, M. J. Biol. Chem. (1994) [Pubmed]
  20. Molecular cloning and chromosomal localization of a human gene encoding D-amino-acid oxidase. Fukui, K., Miyake, Y. J. Biol. Chem. (1992) [Pubmed]
  21. An environmentally regulated receptor for diamine oxidase modulates human endothelial cell/fibroblast histamine degradative uptake. Baenziger, N.L., Mack, P., Jong, Y.J., Dalemar, L.R., Perez, N., Lindberg, C., Wilhelm, B., Haddock, R.C. J. Biol. Chem. (1994) [Pubmed]
  22. Histamine degradative uptake by cultured human pulmonary vascular endothelial cells utilizes an inflammatory cell diamine oxidase. Baenziger, N.L., Dalemar, L.R., Mack, P., Haddock, R.C. J. Biol. Chem. (1994) [Pubmed]
  23. Diamine oxidase is the amiloride-binding protein and is inhibited by amiloride analogues. Novotny, W.F., Chassande, O., Baker, M., Lazdunski, M., Barbry, P. J. Biol. Chem. (1994) [Pubmed]
  24. Cloning, sequence analysis, and characterization of the 'lysyl oxidase' from Pichia pastoris. Kucha, J.A., Dooley, D.M. J. Inorg. Biochem. (2001) [Pubmed]
  25. Putrescine-sensitive (artifactual) and insensitive (biosynthetic) S-adenosyl-L-methionine decarboxylase activities of Lathyrus sativus seedlings. Suresh, M.R., Adiga, P.R. Eur. J. Biochem. (1977) [Pubmed]
  26. Comparative mapping of the human homologue of the rat diabetes susceptibility gene lyp to a 1.3-Mb segment on HSA7. Hornum, L., Markholst, H. Genomics (2000) [Pubmed]
  27. The prognostic and biological significance of cellular heterogeneity in medullary thyroid carcinoma: a study of calcitonin, L-dopa decarboxylase, and histaminase. Lippman, S.M., Mendelsohn, G., Trump, D.L., Wells, S.A., Baylin, S.B. J. Clin. Endocrinol. Metab. (1982) [Pubmed]
  28. Quick recovery of serum diamine oxidase activity in patients undergoing total gastrectomy by oral enteral nutrition. Kamei, H., Hachisuka, T., Nakao, M., Takagi, K. Am. J. Surg. (2005) [Pubmed]
  29. A population-based study of the white-coat blood pressure effect: positive correlation with plasma cortisol. Nyström, F., Aardal, E., Ohman, K.P. Clin. Exp. Hypertens. (1998) [Pubmed]
  30. Changes in serum diamine oxidase activity during chemotherapy in patients with hematological malignancies. Tsujikawa, T., Uda, K., Ihara, T., Inoue, T., Andoh, A., Fujiyama, Y., Bamba, T. Cancer Lett. (1999) [Pubmed]
  31. Diamine oxidase: an overview of historical, biochemical and functional aspects. Wolvekamp, M.C., de Bruin, R.W. Digestive diseases (Basel, Switzerland) (1994) [Pubmed]
  32. Conformational dynamics underlie the activity of the auxin-binding protein, Nt-abp1. David, K., Carnero-Diaz, E., Leblanc, N., Monestiez, M., Grosclaude, J., Perrot-Rechenmann, C. J. Biol. Chem. (2001) [Pubmed]
  33. Mapping the auxin-binding site of auxin-binding protein 1. Brown, J.C., Jones, A.M. J. Biol. Chem. (1994) [Pubmed]
WikiGenes - Universities