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Chemical Compound Review

CHEMBL176800     N-[3-(4-aminobutylamino) propyl]ethanamide

Synonyms: CHEBI:17927, HMDB01276, AC1Q5PFT, AR-1J8235, AC1L19D7, ...
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Disease relevance of an N-acetylspermidine


High impact information on an N-acetylspermidine


Chemical compound and disease context of an N-acetylspermidine


Biological context of an N-acetylspermidine


Anatomical context of an N-acetylspermidine


Associations of an N-acetylspermidine with other chemical compounds


Gene context of an N-acetylspermidine


Analytical, diagnostic and therapeutic context of an N-acetylspermidine


  1. Selective elevation of the N1-acetylspermidine level in human colorectal adenocarcinomas. Takenoshita, S., Matsuzaki, S., Nakano, G., Kimura, H., Hoshi, H., Shoda, H., Nakamura, T. Cancer Res. (1984) [Pubmed]
  2. Urinary excretion of N1-acetylspermidine and other acetylated and free polyamines in the 1,2-dimethylhydrazine model of experimental rat colon cancer. Halline, A.G., Dudeja, P.K., Lashner, B.A., Brasitus, T.A. Cancer Res. (1989) [Pubmed]
  3. Expression of spermidine/spermine N1-acetyltransferase in growing Yoshida AH-130 hepatoma cells. Desiderio, M.A., Bardella, L. Hepatology (1994) [Pubmed]
  4. Enhanced urinary excretion of N1-acetylspermidine and the presence of tumors. Seiler, N., Graham, A., Bartholeyns, J. Cancer Res. (1981) [Pubmed]
  5. 1,2-Dimethylhydrazine-induced alterations in N1-acetylspermidine levels and spermidine N1-acetyltransferase activity in rat colonic mucosa. Halline, A.G., Dudeja, P.K., Brasitus, T.A. Cancer Res. (1989) [Pubmed]
  6. Elevation of acetylpolyamine levels in mouse tissues, serum and urine after treatment with radical-producing drugs and lipopolysaccharide. Sugimoto, H., Yamada, S., Arai, T., Kobayashi, S., Hamana, K., Matsuzaki, S. Hepatology (1988) [Pubmed]
  7. Elevation of N1-acetylspermidine and putrescine in hepatic tissues of patients with fulminant hepatitis and liver cirrhosis. Sugimoto, H., Sakurai, S., Abe, T., Takagi, H., Takahashi, H., Takezawa, J., Nagamine, T., Matsuzaki, S. J. Gastroenterol. (1994) [Pubmed]
  8. Aortic stenosis produces hypertrophy of the rat heart without causing an accumulation of N1-acetylspermidine. Mezl, V.A., Villemure, C., Garber, P.M., Rakusan, K. Biochem. Cell Biol. (1988) [Pubmed]
  9. Premalignant alterations in rat colonic N1-acetylspermidine levels induced by 1,2-dimethylhydrazine: effects of a high corn oil dietary regimen. Halline, A.G., Dudeja, P.K., Brasitus, T.A. Biochim. Biophys. Acta (1989) [Pubmed]
  10. Enhancement of the spermidine uptake system and lethal effects of spermidine overaccumulation in ornithine decarboxylase-overproducing L1210 cells under hyposmotic stress. Poulin, R., Coward, J.K., Lakanen, J.R., Pegg, A.E. J. Biol. Chem. (1993) [Pubmed]
  11. Post-translational modification of the protein-synthesis initiation factor eIF-4D by spermidine in rat hepatoma cells. Gerner, E.W., Mamont, P.S., Bernhardt, A., Siat, M. Biochem. J. (1986) [Pubmed]
  12. N-(3-aminopropyl)pyrrolidin-2-one, a product of spermidine catabolism in vivo. Seiler, N., Knödgen, B., Haegele, K. Biochem. J. (1982) [Pubmed]
  13. Effect of N8-acetylspermidine deacetylase inhibition on the growth of L1210 cells. Wang, Z., Fries, D., Blankenship, J. Biochem. Pharmacol. (1999) [Pubmed]
  14. Perturbation of polyamine metabolism and its relation to cell death in human colon cancer cells treated by 7beta-hydroxycholesterol and 7beta-hydroxysitosterol. Roussi, S., Goss??, F., Aoud??-Werner, D., Zhang, X., Geoffroy, P., Miesch, M., Marchioni, E., Raul, F. Int. J. Oncol. (2006) [Pubmed]
  15. Glucocorticoid regulation of spermidine acetylation in the rat brain. Ientile, R., De Luca, G., Di Giorgio, R.M., Macaione, S. J. Neurochem. (1988) [Pubmed]
  16. Occurrence in high concentrations of N1-acetylspermidine and syn-homospermidine in the hamster epididymis. Matsuzaki, S., Hamana, K., Imai, K., Matsuura, K. Biochem. Biophys. Res. Commun. (1982) [Pubmed]
  17. Secretin-induced accumulation of N1-acetylspermidine and putrescine in the rat pancreas. Danzin, C., Bolkenius, F.N., Claverie, N., Wagner, J., Grove, J. Biochem. Biophys. Res. Commun. (1982) [Pubmed]
  18. Pattern of polyamines and related monoacetyl derivatives in chick embryo retina during development. Taibi, G., Schiavo, M.R., Calvaruso, G., Tesoriere, G. Int. J. Dev. Neurosci. (1994) [Pubmed]
  19. Polyamines and ripening of photoreceptor outer segments in chicken embryos. Taibi, G., Schiavo, M.R., Nicotra, C. Int. J. Dev. Neurosci. (1995) [Pubmed]
  20. Circadian rhythmicity of polyamine urinary excretion. Hrushesky, W.J., Merdink, J., Abdel-Monem, M.M. Cancer Res. (1983) [Pubmed]
  21. Metabolic and antiproliferative consequences of activated polyamine catabolism in LNCaP prostate carcinoma cells. Kee, K., Vujcic, S., Merali, S., Diegelman, P., Kisiel, N., Powell, C.T., Kramer, D.L., Porter, C.W. J. Biol. Chem. (2004) [Pubmed]
  22. Polyamine catabolism in rodent and human cells in culture. Carper, S.W., Tome, M.E., Fuller, D.J., Chen, J.R., Harari, P.M., Gerner, E.W. Biochem. J. (1991) [Pubmed]
  23. Guide molecule-driven stereospecific degradation of alpha-methylpolyamines by polyamine oxidase. Järvinen, A., Keinänen, T.A., Grigorenko, N.A., Khomutov, A.R., Uimari, A., Vepsäläinen, J., Närvänen, A., Alhonen, L., Jänne, J. J. Biol. Chem. (2006) [Pubmed]
  24. Mechanistic studies of mouse polyamine oxidase with N1,N12-bisethylspermine as a substrate. Royo, M., Fitzpatrick, P.F. Biochemistry (2005) [Pubmed]
  25. Pneumocystis carinii polyamine catabolism. Merali, S. J. Biol. Chem. (1999) [Pubmed]
  26. Targeted expression of spermidine/spermine N1-acetyltransferase increases susceptibility to chemically induced skin carcinogenesis. Coleman, C.S., Pegg, A.E., Megosh, L.C., Guo, Y., Sawicki, J.A., O'Brien, T.G. Carcinogenesis (2002) [Pubmed]
  27. Glucocorticoids suppress and oestrogens enhance the lipopolysaccharide-induced increase in putrescine and N1-acetylspermidine in mouse liver. Sugimoto, H., Hamana, K., Masxuzaki, S., Arai, T., Yamada, S. J. Steroid Biochem. Mol. Biol. (1991) [Pubmed]
  28. A new enzyme-linked immunosorbent assay (ELISA) for studying immunocytochemical procedures using an antiserum produced against spermidine as a model. Fujiwara, K., Araki, M., Kitagawa, T., Inoue, Y. Histochemistry (1993) [Pubmed]
  29. Acetylated polyamines in lungs from rats with monocrotaline-induced pneumotoxicity. Orlinska, U., Olson, J.W., Gebb, S.A., Gillespie, M.N. Fundamental and applied toxicology : official journal of the Society of Toxicology. (1989) [Pubmed]
  30. 1-N-Acetylspermidine: occurrence in normal human serum. Smith, R.G., Bartos, D., Bartos, F., Grettie, D.P., Frick, W., Campbell, R.A., Daves, G.D. Biomed. Mass Spectrom. (1978) [Pubmed]
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