Disease relevance of palmitic acid ethyl ester

• Ethyl palmitate induces abnormal movement and the formation of unusual club shaped pseudopodia; ethyl palmitate prevents the ingestion of antibody coated erythrocytes and it is postulated that this substance interferes with the syntheses of IgG receptors [1].
• The effect of intravenous injection of ethyl palmitate emulsion on sequestration of thermally damaged erythrocytes in rats with experimentally induced hypersplenism, and in normal rats [2].

High impact information on palmitic acid ethyl ester

• Treatment with ethyl palmitate resulted in diminished retention of carbon in both liver and spleen; this lipid, unlike tricaprin or cholesterol oleate, was cytotoxic to both macrophages and lymphocytes [3].
• STUDY DESIGN AND METHODS: Viability of platelet concentrates (PCs) WBC reduced before storage was determined by flow cytometry in rabbits whose reticuloendothelial system was inhibited by ethyl palmitate administration [4].
• Ethyl palmitate was added as an internal standard before hydrogenation [5].
• Role of macrophages in experimental malaria: V--Effect of ethyl palmitate on macrophages in Plasmodium berghei infected mice [6].
• In mice subjected to chemical splenectomy by means of ethyl palmitate the number of CFU-S and CFU-C in bone marrow and spleen was assessed [7].

Biological context of palmitic acid ethyl ester

• The experiments revealed that the inhibitory effect of ethyl palmitate on antibody production was temporary only, and at a later stage could be compensated by an enhanced antibody activity [8].

Anatomical context of palmitic acid ethyl ester

• Two weeks later, human platelets were transfused to animals whose reticuloendothelial systems were inhibited by the administration of ethyl palmitate [9].
• The T1/2 survival of human erythrocytes in guinea pigs treated with ethyl palmitate and cobra venom factor is about 3 days [10].

Analytical, diagnostic and therapeutic context of palmitic acid ethyl ester

• After applying ethyl palmitate an extensive splenic necrosis could be induced resulting in an elimination of the sequestrational splenic function to an extent comparable to surgical splenectomy [11].
• Experimental elimination of the splenic function by an intravenous injection of ethyl palmitate emulsion in Wistar rats [12].

References