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Chemical Compound Review:

SCPB (2S)-N-[(1S)-1-[[(1S)-1- [[(1S)-1-[[(2S)-1...

Synonyms: AC1L3XED, AR-1J3345, NCGC00167203-01, Met-asn-tyr-leu-ala-phe-pro-arg-met-NH2

Watson, W.H. et al., Lukowiak, K. et al., Ferretti, M.E. et al., Xu, Y. et al., Mahon, A.C. et al., et al.

Settembrini, Villar, Moffett, Moffett,

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Disease relevance of small cardioactive peptide B

The buccal ganglion of each species possessed a pair of large, dorsal-lateral, whitish neurons that contained an SCPB-like peptide [1].

High impact information on small cardioactive peptide B

We have identified cells in the central nervous system of the marine mollusc Aplysia that react with antibody raised against the small cardioactive peptide B (SCPB) [2].
The amino acid sequences for SCPB and a related peptide, SCPA, are present and are flanked by known proteolytic processing sites [2].
1. Serotonin (5-HT), small cardioactive peptide B (SCPB) and FMRFamide have well-established facilitatory and inhibitory effects on sensory neurons and their connections with motor neurons mediating withdrawal reflexes in Aplysia [3].
Therefore, the effects of SCPB were essentially opposite to those of 5-HT on this inhibitory interneuron [3].
Effects of the small cardioactive peptide B (SCPB) on adenylate cyclase of the central nervous system and peripheral organs of the freshwater snail Planorbarius corneus [4].

Chemical compound and disease context of small cardioactive peptide B

The suprafusion of two endogenous neuropeptides, arginine vasotocin (AVT) and small cardioactive peptide B (SCPB), over the abdominal ganglion of Aplysia californica significantly affects the ability of a central gill motor neuron to elicit a gill withdrawal response [5].

Biological context of small cardioactive peptide B

Influence of small cardioactive peptide (b) on the efficiency of synaptic transmission and the excitability of command neurons of the defensive behavior of the edible snail [6].
In pupae, but not in larvae or adults, the gut RF-l system coexpresses reactivity to antibodies raised against a member of another peptide family, molluscan small cardioactive peptide b (SCP-I) [7].

Anatomical context of small cardioactive peptide B

The buccal ganglia of seven nudibranches (Aeolidia papillosa, Armina californica, Dirona albolineata, D. picta, Hermissenda crassicornis, Melibe leonina, and Tritonia diomedea) were examined to explore possible homologies between large cells that reacted with antibodies directed against small cardioactive peptide B (SCPB) [1].
The distribution pattern of small cardioactive peptide B (SCP(B))-LI was also widespread, with immunolabeled somata surrounding every neuropil region of the brain and subesophageal ganglion, except for the optic lobe [8].

Associations of small cardioactive peptide B with other chemical compounds

The effect of the small cardioactive peptide B (SCPB) on adenylate cyclase activity of the central nervous system (CNS) and some peripheral organs of the freshwater snail Planorbarius corneus was investigated [4].
When AVT (10(-6)M) was suprafused, the motor neurons' ability to elicit a gill movement was suppressed; while SCPB (10(-6)M) superfusion facilitated the response [5].

Gene context of small cardioactive peptide B

Finally, perfusion of isolated buccal ganglia with SCPB excites the SLB cells and activates FMPs [1].

Analytical, diagnostic and therapeutic context of small cardioactive peptide B

In accordance with their putative roles as neuromodulators, immunocytochemistry revealed FMRFamide-like and SCPB-like fibers on the muscle surface [9].

References

Evidence for homologous peptidergic neurons in the buccal ganglia of diverse nudibranch mollusks. Watson, W.H., Willows, A.O. J. Neurobiol. (1992) [Pubmed]
The small cardioactive peptides A and B of Aplysia are derived from a common precursor molecule. Mahon, A.C., Lloyd, P.E., Weiss, K.R., Kupfermann, I., Scheller, R.H. Proc. Natl. Acad. Sci. U.S.A. (1985) [Pubmed]
Modulation of an inhibitory interneuron in the neural circuitry for the tail withdrawal reflex of Aplysia. Xu, Y., Pieroni, J.P., Cleary, L.J., Byrne, J.H. J. Neurophysiol. (1995) [Pubmed]
Effects of the small cardioactive peptide B (SCPB) on adenylate cyclase of the central nervous system and peripheral organs of the freshwater snail Planorbarius corneus. Ferretti, M.E., Sonetti, D., Pareschi, M.C., Biondi, C. Neurochem. Int. (1993) [Pubmed]
Endogenous peptides work at multiple sites in the nervous system in the control of gill behaviors in Aplysia. Lukowiak, K., Colmers, W.F. Regul. Pept. (1987) [Pubmed]
Influence of small cardioactive peptide (b) on the efficiency of synaptic transmission and the excitability of command neurons of the defensive behavior of the edible snail. Bravarenko, N.I. Neurosci. Behav. Physiol. (1992) [Pubmed]
Comparison of immunoreactivity to serotonin, FMRFamide and SCPb in the gut and visceral nervous system of larvae, pupae and adults of the yellow fever mosquito Aedes aegypti. Moffett, S.B., Moffett, D.F. J. Insect Sci. (2005) [Pubmed]
FMRFamide-like immunocytochemistry in the brain and subesophageal ganglion of Triatoma infestans (Insecta: Heteroptera). Coexpression with beta-pigment-dispersing hormone and small cardioactive peptide B. Settembrini, B.P., Villar, M.J. Cell Tissue Res. (2005) [Pubmed]
Peptidergic modulation of a neuromuscular junction in Aplysia: bioactivity and immunocytochemistry. Richmond, J.E., Bulloch, A.G., Lukowiak, K. Brain Res. (1986) [Pubmed]

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