The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

CS-722     4-chloro-2-[(2R)-2-hydroxy-3- morpholin-4...

Synonyms: SureCN7518237, CS 722, AC1L31DQ, 144886-17-9
This record was replaced with 132660.
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of 4-chloro-2-[(2R)-2-hydroxy-3-morpholino-propyl]-5-phenyl-isoxazol-3-one


High impact information on 4-chloro-2-[(2R)-2-hydroxy-3-morpholino-propyl]-5-phenyl-isoxazol-3-one


Biological context of 4-chloro-2-[(2R)-2-hydroxy-3-morpholino-propyl]-5-phenyl-isoxazol-3-one

  • The drug CS-722 (50 mg/kg, i.v.) depressed the polysynaptic reflex but was less effective on the monosynaptic reflex [5].
  • Spinal reflexes were not affected by CS-722 injected i.c.v. It seems that muscle relaxation is not always accompanied by impairment of the spinal reflex [4].

Anatomical context of 4-chloro-2-[(2R)-2-hydroxy-3-morpholino-propyl]-5-phenyl-isoxazol-3-one

  • Doses injected intra-4th ventricularly (i.c.v.) or intrathecally (i.t.) were determined according to measurements of CS-722 concentration in the brain stem and the spinal cord after systemic administration [4].


  1. The pharmacological properties of CS-722, a newly synthesized centrally acting muscle relaxant. Tanabe, M., Kaneko, T., Tonohiro, T., Iwata, N. Neuropharmacology (1992) [Pubmed]
  2. The effects of the muscle relaxant, CS-722, on synaptic activity of cultured neurones. Marszalec, W., Song, J.H., Narahashi, T. Br. J. Pharmacol. (1996) [Pubmed]
  3. Preferential enhancement of inhibitory synaptic transmission by CS-722 in the ventral horn neurons of neonatal rat spinal cord. Tanabe, M., Kaneko, T. Eur. J. Pharmacol. (1996) [Pubmed]
  4. Sites of action of CS-722, a newly synthesized centrally acting muscle relaxant. Tanabe, M., Ishizuka, H., Murayama, T., Kaneko, T., Tonohiro, T., Sakai, J., Nagano, M., Sasahara, K., Iwata, N. Jpn. J. Pharmacol. (1993) [Pubmed]
  5. Mechanisms of spinal reflex depressant effects of CS-722, a newly synthesized centrally acting muscle relaxant, in spinal rats. Tanabe, M., Kaneko, T., Tonohiro, T., Iwata, N. Neuropharmacology (1992) [Pubmed]
WikiGenes - Universities