Disease relevance of Decerebrate State

• Then he had episodes of myoclonus, reversal of intellectual development, rigidity with decerebrate posturing and epilepsy, which became severe [1].
• The second patient, a 10-year-old boy in stage IV coma, had decerebrate posturing and anisocoria [2].
• Three weeks later, the decerebrate rigidity and high BP remained, and tizanidine was initiated to see whether the decrease in muscle tone could facilitate hypertension control and motor recovery [3].
• Five cases of near drowning (ND) in cold water, who presented with varied clinical picture like coma with decerebrate rigidity and fixed dilated pupils, hypertension with coma and delayed pulmonary oedema (Secondary drowning) are reported [4].
• These differences depend upon the extent to which dynamic and static stretch reflexes are released, and whether the control effects of flexor reflex afferents remain under the control of the brain stem (as in Parkinson's disease), are released (as in spasticity) or even reversed (as in decerebrate rigidity) [5].

High impact information on Decerebrate State

• Electroencephalograms recorded immediately after admission showed [1] slow wave activity, and [2] bizarre rhythmical bursts of high-voltage sharp wave activity; both of which rapidly resolved during the next 24 hours, as did the associated clinical findings of hyperreflexia, bilateral dorsiflexor Babinski responses, and decerebrate posturing [6].
• Two cases of decerebrate posturing that resolved following the administration of dextrose are reported [7].
• In cats decerebrated by a midcollicular section, decerebrate rigidity developed that was not alleviated by phenytoin even in doses as great as 60 mg per kilogram [8].
• Chlorpromazine that depresses decerebrate rigidity in a dose-related fashion requires 1.5 to 2.0 mg per kilogram to exhibit an appreciable effect [8].
• Following intravenous administration of the serotonin precursor 5-hydroxytryptophan, mimicking the tonic activity of these pathways in the decerebrate state, it was again possible to elicit the long-lasting excitability increase by a train of impulses in Ia afferents [9].

Chemical compound and disease context of Decerebrate State

• In addition to the oxazolidinones, an aminoalcohol derivative, (1RS,2SR)-5-methyl-1-phenyl-2-(3-piperidinopropylamino )hexan-1-ol (MLV-5860) also reduced the rat decerebrate rigidity [10].
• Central fevers after TBI have been reported to have been treated successfully with propranolol in two children with decerebrate posturing [11].
• Zopiclone selectively reduced the phasic responses of anemic decerebrate rigidity like benzodiazepines in rats [12].
• In order to obtain spontaneous discharge in this vagal branch and optimal recording conditions, we compared the decerebrate state to urethane, urethane-chloralose and pentobarbital-chloralose anaesthesia with regard to level of chronotropic cardiac vagal tone [13].
• When administered i.c.v. (50 and 100 micrograms) or i.t. (200 and 400 micrograms), CS-722 reduced the radio frequency decerebrate rigidity, although the effect after i.c.v. injection was transient [14].

Anatomical context of Decerebrate State

• Decompressive haemicraniectomy without cortical excision was unable to revert coma and decerebrate posturing because of a massive temporal muscle haemorrhage with persistent contralateral deviation of midline structures [15].

Gene context of Decerebrate State

• A woman, aged 38, lost consciousness immediately after manipulation of the cervical spine and remained in coma for nearly 5 years in a combined decorticate and decerebrate state [16].
• All derive their rationale from the classical concepts of decerebrate rigidity and of brain organization as discussed in Part I [17].
• The patient began to exhibit symptoms consistent with NMS (high fever, dystonia, diaphoresis, tachycardia, and decerebrate posturing) shortly after administration of the haloperidol [18].
• We report five cases in which children with hydrocephalus and CSF shunts presented with a variety of recurring symptoms, including headache, vomiting, impairment of consciousness to the point of coma, and, in one patient, decerebrate posturing [19].

Analytical, diagnostic and therapeutic context of Decerebrate State

• Physical examination showed signs of upper brainstem lesion such as discoordination, bilateral Babinski signs, and internuclear ophthalmic palsy without persistent coma and decerebrate rigidity [20].

References