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MeSH Review

Decerebrate State

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Disease relevance of Decerebrate State


High impact information on Decerebrate State

  • Electroencephalograms recorded immediately after admission showed [1] slow wave activity, and [2] bizarre rhythmical bursts of high-voltage sharp wave activity; both of which rapidly resolved during the next 24 hours, as did the associated clinical findings of hyperreflexia, bilateral dorsiflexor Babinski responses, and decerebrate posturing [6].
  • Two cases of decerebrate posturing that resolved following the administration of dextrose are reported [7].
  • In cats decerebrated by a midcollicular section, decerebrate rigidity developed that was not alleviated by phenytoin even in doses as great as 60 mg per kilogram [8].
  • Chlorpromazine that depresses decerebrate rigidity in a dose-related fashion requires 1.5 to 2.0 mg per kilogram to exhibit an appreciable effect [8].
  • Following intravenous administration of the serotonin precursor 5-hydroxytryptophan, mimicking the tonic activity of these pathways in the decerebrate state, it was again possible to elicit the long-lasting excitability increase by a train of impulses in Ia afferents [9].

Chemical compound and disease context of Decerebrate State

  • In addition to the oxazolidinones, an aminoalcohol derivative, (1RS,2SR)-5-methyl-1-phenyl-2-(3-piperidinopropylamino )hexan-1-ol (MLV-5860) also reduced the rat decerebrate rigidity [10].
  • Central fevers after TBI have been reported to have been treated successfully with propranolol in two children with decerebrate posturing [11].
  • Zopiclone selectively reduced the phasic responses of anemic decerebrate rigidity like benzodiazepines in rats [12].
  • In order to obtain spontaneous discharge in this vagal branch and optimal recording conditions, we compared the decerebrate state to urethane, urethane-chloralose and pentobarbital-chloralose anaesthesia with regard to level of chronotropic cardiac vagal tone [13].
  • When administered i.c.v. (50 and 100 micrograms) or i.t. (200 and 400 micrograms), CS-722 reduced the radio frequency decerebrate rigidity, although the effect after i.c.v. injection was transient [14].

Anatomical context of Decerebrate State


Gene context of Decerebrate State

  • A woman, aged 38, lost consciousness immediately after manipulation of the cervical spine and remained in coma for nearly 5 years in a combined decorticate and decerebrate state [16].
  • All derive their rationale from the classical concepts of decerebrate rigidity and of brain organization as discussed in Part I [17].
  • The patient began to exhibit symptoms consistent with NMS (high fever, dystonia, diaphoresis, tachycardia, and decerebrate posturing) shortly after administration of the haloperidol [18].
  • We report five cases in which children with hydrocephalus and CSF shunts presented with a variety of recurring symptoms, including headache, vomiting, impairment of consciousness to the point of coma, and, in one patient, decerebrate posturing [19].

Analytical, diagnostic and therapeutic context of Decerebrate State


  1. Alzheimer's tangles in sudanophilic leukodystrophy. Harada, K., Krucke, W., Mancardi, J.L., Mandybur, T.I. Neurology (1988) [Pubmed]
  2. Neurological and psychological sequelae in transplant recipients after bridging with the bioartificial liver. Coffman, K.L., Hoffman, A., Rosenthal, P., Demetriou, A., Makowka, L. General hospital psychiatry. (1996) [Pubmed]
  3. Hypotension due to interaction between lisinopril and tizanidine. Kao, C.D., Chang, J.B., Chen, J.T., Wu, Z.A., Shan, D.E., Liao, K.K. The Annals of pharmacotherapy. (2004) [Pubmed]
  4. Near drowning in cold water. Mehta, S.R., Srinivasan, K.V., Bindra, M.S., Kumar, M.R., Lahiri, A.K. The Journal of the Association of Physicians of India. (2000) [Pubmed]
  5. Disordered muscle tone and movement. Lance, J.W. Clinical and experimental neurology. (1981) [Pubmed]
  6. Acute anticholinergic syndrome due to Jimson seed ingestion. Clinical and laboratory observation in six cases. Mikolich, J.R., Paulson, G.W., Cross, C.J. Ann. Intern. Med. (1975) [Pubmed]
  7. Reversible decerebrate posturing secondary to hypoglycemia. Seibert, D.G. Am. J. Med. (1985) [Pubmed]
  8. Suppression of decerebrate rigidity by phenytoin and chlorpromazine. Anderson, R.J., Raines, A. Neurology (1976) [Pubmed]
  9. Maintained changes in motoneuronal excitability by short-lasting synaptic inputs in the decerebrate cat. Crone, C., Hultborn, H., Kiehn, O., Mazieres, L., Wigström, H. J. Physiol. (Lond.) (1988) [Pubmed]
  10. A new class of potent centrally acting muscle relaxants: pharmacology of oxazolidinones in rat decerebrate rigidity. Masaki, M., Shinozaki, H. Br. J. Pharmacol. (1986) [Pubmed]
  11. Fever of central origin in traumatic brain injury controlled with propranolol. Meythaler, J.M., Stinson, A.M. Archives of physical medicine and rehabilitation. (1994) [Pubmed]
  12. Effects of zopiclone and benzodiazepines on spinal reflexes, anemic decerebrate rigidity and benzodiazepine binding. Goto, M., Ono, H., Matsumoto, K., Kondo, M., Fukuda, H. Jpn. J. Pharmacol. (1983) [Pubmed]
  13. Discharge patterns of preganglionic neurones with axons in a cardiac vagal branch in the rat. O'Leary, D.M., Jones, J.F. Exp. Physiol. (2003) [Pubmed]
  14. Sites of action of CS-722, a newly synthesized centrally acting muscle relaxant. Tanabe, M., Ishizuka, H., Murayama, T., Kaneko, T., Tonohiro, T., Sakai, J., Nagano, M., Sasahara, K., Iwata, N. Jpn. J. Pharmacol. (1993) [Pubmed]
  15. Temporal muscle haematoma as a cause of suboptimal haemicraniectomy: case report. André, C., Py, M.d.e. .O., Niemeyer-Filho, P. Arquivos de neuro-psiquiatria. (2003) [Pubmed]
  16. Brainstem lesion with coma for five years following manipulation of the cervical spine. Nyberg-Hansen, R., Løken, A.C., Tenstad, O. J. Neurol. (1978) [Pubmed]
  17. Spasticity: its physiology and management. Part IV. Current and projected treatment procedures for spasticity. Bishop, B. Physical therapy. (1977) [Pubmed]
  18. Neuroleptic malignant syndrome induced by haloperidol following traumatic brain injury. Wilkinson, R., Meythaler, J.M., Guin-Renfroe, S. Brain injury : [BI]. (1999) [Pubmed]
  19. Migraine headaches in hydrocephalic children: a diagnostic dilemma. Nowak, T.P., James, H.E. Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery. (1989) [Pubmed]
  20. Primary brainstem injury without persistent coma and decerebrate rigidity. Report of 2 cases. Li, J.R., Peng, R.L. Chin. Med. J. (1989) [Pubmed]
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