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Chemical Compound Review

alpha-Ctx-imi     (3S)-4-[(2S)-2-[[(1S)-1- [[(1S)-1-[[(1S)-1...

Synonyms: Conotoxin IMI, alpha-CTX IMI, CHEMBL500076, CTX IMI, AC1L3206, ...
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High impact information on alpha-Ctx-imi


Biological context of alpha-Ctx-imi

  • Several lines of evidence revealed that the inhibitory effect of alpha-conotoxin-ImI was competitive with respect to the agonist (IC50 approximately 85 nM) and reversible by washing [5].

Anatomical context of alpha-Ctx-imi


Associations of alpha-Ctx-imi with other chemical compounds


Analytical, diagnostic and therapeutic context of alpha-Ctx-imi

  • In the present study, the patch-clamp technique was applied to rat hippocampal neurons or myoballs in culture to study the actions of alpha-conotoxin-ImI on the native alpha-bungarotoxin-sensitive, presumably alpha 7-bearing, neuronal nicotinic receptor and on other ligand-gated channels [5].


  1. Unmasking the functions of the chromaffin cell alpha7 nicotinic receptor by using short pulses of acetylcholine and selective blockers. López, M.G., Montiel, C., Herrero, C.J., García-Palomero, E., Mayorgas, I., Hernández-Guijo, J.M., Villarroya, M., Olivares, R., Gandía, L., McIntosh, J.M., Olivera, B.M., García, A.G. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  2. Alpha-conotoxins ImI and ImII. Similar alpha 7 nicotinic receptor antagonists act at different sites. Ellison, M., McIntosh, J.M., Olivera, B.M. J. Biol. Chem. (2003) [Pubmed]
  3. Complex intracellular messenger pathways regulate one type of neuronal alpha-bungarotoxin-resistant nicotinic acetylcholine receptors expressed in insect neurosecretory cells (dorsal unpaired median neurons). Courjaret, R., Lapied, B. Mol. Pharmacol. (2001) [Pubmed]
  4. alpha-bungarotoxin-sensitive nicotinic receptors indirectly modulate [(3)H]dopamine release in rat striatal slices via glutamate release. Kaiser, S., Wonnacott, S. Mol. Pharmacol. (2000) [Pubmed]
  5. Alpha-conotoxin-ImI: a competitive antagonist at alpha-bungarotoxin-sensitive neuronal nicotinic receptors in hippocampal neurons. Pereira, E.F., Alkondon, M., McIntosh, J.M., Albuquerque, E.X. J. Pharmacol. Exp. Ther. (1996) [Pubmed]
  6. Alpha-conotoxin ImI inhibits the alpha-bungarotoxin-resistant nicotinic response in bovine adrenal chromaffin cells. Broxton, N.M., Down, J.G., Gehrmann, J., Alewood, P.F., Satchell, D.G., Livett, B.G. J. Neurochem. (1999) [Pubmed]
  7. Different nicotinic acetylcholine receptor subtypes mediating striatal and prefrontal cortical [3H]dopamine release. Cao, Y.J., Surowy, C.S., Puttfarcken, P.S. Neuropharmacology (2005) [Pubmed]
  8. A comparative study on selectivity of alpha-conotoxins GI and ImI using their synthetic analogues and derivatives. Kasheverov, I.E., Zhmak, M.N., Maslennikov, I.V., Utkin, Y.N., Tsetlin, V.I. Neurochem. Res. (2003) [Pubmed]
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