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Chemical Compound Review

Ephedrone     2-methylamino-1-phenyl- propan-1-one

Synonyms: Methcathinone, SureCN497486, AL-422, AL-463, AL-464, ...
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Disease relevance of Ephedrone

  • In this study we characterized acute methcathinone toxicity in rats, attempting to determine whether the excitatory amino acid receptor antagonist dextrorphan can antagonize methcathinone intoxication [1].
  • RESULTS: Methcathinone caused tachycardia (maximal increase, 131 +/- 10 beats/minute), hyperthermia (+2.3 degrees C), convulsions, and cardiorespiratory collapse in vehicle-pretreated rats (n = 9) [1].

High impact information on Ephedrone


Associations of Ephedrone with other chemical compounds


Analytical, diagnostic and therapeutic context of Ephedrone


  1. Methcathinone intoxication in the rat: abrogation by dextrorphan. Rockhold, R.W., Carlton, F.B., Corkern, R., Derouen, L., Bennett, J.G., Hume, A.S. Annals of emergency medicine. (1997) [Pubmed]
  2. Reduced striatal dopamine transporter density in abstinent methamphetamine and methcathinone users: evidence from positron emission tomography studies with [11C]WIN-35,428. McCann, U.D., Wong, D.F., Yokoi, F., Villemagne, V., Dannals, R.F., Ricaurte, G.A. J. Neurosci. (1998) [Pubmed]
  3. In vitro characterization of ephedrine-related stereoisomers at biogenic amine transporters and the receptorome reveals selective actions as norepinephrine transporter substrates. Rothman, R.B., Vu, N., Partilla, J.S., Roth, B.L., Hufeisen, S.J., Compton-Toth, B.A., Birkes, J., Young, R., Glennon, R.A. J. Pharmacol. Exp. Ther. (2003) [Pubmed]
  4. Methcathinone: an initial study of its effects on monoaminergic systems. Gygi, M.P., Gibb, J.W., Hanson, G.R. J. Pharmacol. Exp. Ther. (1996) [Pubmed]
  5. Inhibition of plasma membrane monoamine transporters by beta-ketoamphetamines. Cozzi, N.V., Sievert, M.K., Shulgin, A.T., Jacob, P., Ruoho, A.E. Eur. J. Pharmacol. (1999) [Pubmed]
  6. Methcathinone: a new postindustrial drug. Belhadj-Tahar, H., Sadeg, N. Forensic Sci. Int. (2005) [Pubmed]
  7. Cathinone (Khat) and methcathinone (CAT) in urine specimens: a gas chromatographic-mass spectrometric detection procedure. Paul, B.D., Cole, K.A. Journal of analytical toxicology. (2001) [Pubmed]
  8. Intravenous self-injection of methcathinone in the baboon. Kaminski, B.J., Griffiths, R.R. Pharmacol. Biochem. Behav. (1994) [Pubmed]
  9. Methcathinone is a substrate for the serotonin uptake transporter. Cozzi, N.V., Foley, K.F. Pharmacol. Toxicol. (2003) [Pubmed]
  10. Chiral identification and determination of ephedrine, pseudoephedrine, methamphetamine and methcathinone by gas chromatography and nuclear magnetic resonance. LeBelle, M.J., Savard, C., Dawson, B.A., Black, D.B., Katyal, L.K., Zrcek, F., By, A.W. Forensic Sci. Int. (1995) [Pubmed]
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