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Chemical Compound Review

CHEBI:15537     [(2R,3S,4R,5R)-5-(6- aminopurin-9-yl)-4...

Synonyms: HMDB06503, AC1L4WYX, C00582, phenylacetyl-CoA, Phenylacetyl-coenzyme A, ...
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Disease relevance of Phenylacetyl-coenzyme A


High impact information on Phenylacetyl-coenzyme A


Chemical compound and disease context of Phenylacetyl-coenzyme A


Biological context of Phenylacetyl-coenzyme A

  • Amplification of phl in an autonomous replicating plasmid led to an 8-fold increase in phenylacetyl-CoA ligase activity and a 35% increase in penicillin production [10].

Anatomical context of Phenylacetyl-coenzyme A


Associations of Phenylacetyl-coenzyme A with other chemical compounds


Gene context of Phenylacetyl-coenzyme A


  1. On the possible mechanism of phenylacetate neurotoxicity: inhibition of choline acetyltransferase by phenylacetyl-CoA. Potempska, A., Loo, Y.H., Wisniewski, H.M. J. Neurochem. (1984) [Pubmed]
  2. Genetic Characterization of the Phenylacetyl-Coenzyme A Oxygenase from the Aerobic Phenylacetic Acid Degradation Pathway of Escherichia coli. Fern??ndez, C., Ferr??ndez, A., Mi??ambres, B., D??az, E., Garc??a, J.L. Appl. Environ. Microbiol. (2006) [Pubmed]
  3. Coregulation by phenylacetyl-coenzyme A-responsive PaaX integrates control of the upper and lower pathways for catabolism of styrene by Pseudomonas sp. strain Y2. del Peso-Santos, T., Bartolomé-Martín, D., Fernández, C., Alonso, S., García, J.L., Díaz, E., Shingler, V., Perera, J. J. Bacteriol. (2006) [Pubmed]
  4. Phenylacetyl-CoA:acceptor oxidoreductase, a membrane-bound molybdenum-iron-sulfur enzyme involved in anaerobic metabolism of phenylalanine in the denitrifying bacterium Thauera aromatica. Rhee, S.K., Fuchs, G. Eur. J. Biochem. (1999) [Pubmed]
  5. Direct evaluation of phenylacetyl-CoA: 6-aminopenicillanic acid acyltransferase of Penicillium chrysogenum by bioassay. Luengo, J.M., Iriso, J.L., López-Nieto, M.J. J. Antibiot. (1986) [Pubmed]
  6. Characterization of the Substrate Specificity of PhlD, a Type III Polyketide Synthase from Pseudomonas fluorescens. Zha, W., Rubin-Pitel, S.B., Zhao, H. J. Biol. Chem. (2006) [Pubmed]
  7. Catabolism of phenylacetic acid in Escherichia coli. Characterization of a new aerobic hybrid pathway. Ferrández, A., Miñambres, B., García, B., Olivera, E.R., Luengo, J.M., García, J.L., Díaz, E. J. Biol. Chem. (1998) [Pubmed]
  8. The PaaX repressor, a link between penicillin G acylase and the phenylacetyl-coenzyme A catabolon of Escherichia coli W. Galán, B., García, J.L., Prieto, M.A. J. Bacteriol. (2004) [Pubmed]
  9. Purification and characterization of two reversible and ADP-dependent acetyl coenzyme A synthetases from the hyperthermophilic archaeon Pyrococcus furiosus. Mai, X., Adams, M.W. J. Bacteriol. (1996) [Pubmed]
  10. Amplification and disruption of the phenylacetyl-CoA ligase gene of Penicillium chrysogenum encoding an aryl-capping enzyme that supplies phenylacetic acid to the isopenicillin N-acyltransferase. Lamas-Maceiras, M., Vaca, I., Rodríguez, E., Casqueiro, J., Martín, J.F. Biochem. J. (2006) [Pubmed]
  11. Biosynthesis of benzylpenicillin by Penicillium chrysogenum and its Golgi apparatus. Kuryłowicz, W., Kurzatkowski, W., Kurzatkowski, J. Arch. Immunol. Ther. Exp. (Warsz.) (1987) [Pubmed]
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