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Chemical Compound Review

YC-170     2-pyridin-2-ylethyl 4-(2-chlorophenyl)-2,6...

Synonyms: AG-G-14096, AC1L5AEH, CTK5B0742, YC 170, C13760, ...
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Disease relevance of YC-170

  • Using an experimental model of global ischemia of the brain in rats, we have shown that a Ca2+ antagonist nicardipine attenuates, and a Ca2+ agonist YC-170 accelerates, the liberation of free fatty acids in the ischemic whole brain [1].

High impact information on YC-170


Anatomical context of YC-170


Associations of YC-170 with other chemical compounds


  1. Effect of calcium antagonist and agonist on free fatty acid liberation in the ischemic brain of rats. Kidooka, M., Matsuda, M., Handa, J. Surgical neurology. (1987) [Pubmed]
  2. Voltage-dependence of Ca2+ agonist effect of YC-170 on cardiac L-type Ca2+ channels. Takeda, Y., Tohse, N., Nakaya, H., Kanno, M. Br. J. Pharmacol. (1995) [Pubmed]
  3. New 1,4-dihydropyridines with vasoconstrictor action through activation of Ca++-channels. Takenaka, T., Inagaki, O., Terai, M., Asano, M., Kubo, K. J. Pharmacol. Exp. Ther. (1988) [Pubmed]
  4. Vascular and cardiac effects of a new dihydropyridine derivative, YC-170: a comparison with Bay K 8644. Hattori, Y., Nakaya, H., Tohse, N., Kanno, M. J. Pharmacol. Exp. Ther. (1986) [Pubmed]
  5. The attenuated elevation of cytoplasmic calcium concentration following the uptake of low density lipoprotein in type C Niemann-Pick fibroblasts. Yamamoto, T., Tokoro, T., Eto, Y. Biochem. Biophys. Res. Commun. (1994) [Pubmed]
  6. Vascular and insulinotropic effects of YC 170, a calcium agonist, on isolated perfused rat pancreas. Abadie, E., Marre, M., Race, J.M., Luis, N., Passa, P. Diabète & métabolisme. (1990) [Pubmed]
  7. Calcium entry blocking, beta 1-adrenoceptor blocking and hypotensive effects of YM-16151-4. Shibasaki, K., Uchida, W., Matsuda, Y., Asano, M. Archives internationales de pharmacodynamie et de thérapie. (1991) [Pubmed]
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