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Chemical Compound Review

Proxel     7-thia-8- azabicyclo[4.3.0]nona-1,3,5- trien...

Synonyms: Proxel PL, PubChem15685, SureCN26078, CHEMBL297304, SureCN911402, ...
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Gene context of Proxan

  • The short carbonyl bond in the title compound, [Cu(2)(C(7)H(4)NO(3)S)(4)(C(3)H(4)N(2))(4)] [Liu, Huang, Li & Lin (1991). Acta Cryst. C47, 41-43], is an artifact of disorder in the isothiazol-3(2H)-one 1,1-dioxide part of the 1,2-benzisothiazol-3(2H)-one entity [13].


  1. Occupational allergic contact dermatitis from 1,2-benzisothiazolin-3-one without cross-sensitization to other isothiazolinones. Muhn, C., Sasseville, D. Contact Derm. (2003) [Pubmed]
  2. Occupational contact dermatitis to 1,2-benzisothiazolin-3-one and 5-chloro-2-methylisothiazolin-3-one/2-methylisothiazolin-3-one in paint manufacturers. Hardcastle, N.J., Gawkrodger, D.J. Contact Derm. (2005) [Pubmed]
  3. Occupational hand dermatitis due to 1,2-benzisothiazolin-3-one in the water-softener manufacturing industry. Cooper, S.M., Shaw, S. Contact Derm. (1999) [Pubmed]
  4. Occupational dermatitis due to 1,2-benzisothiazolin-3-one in the pottery industry. Roberts, D.L., Messenger, A.G., Summerly, R. Contact Derm. (1981) [Pubmed]
  5. Pulpitis of the fingers from a shoe glue containing 1,2-benzisothiazolin-3-one (BIT). Ayadi, M., Martin, P. Contact Derm. (1999) [Pubmed]
  6. Pericapillary haem-rich deposits: evidence for microhaemorrhages in aging human cerebral cortex. Cullen, K.M., Kócsi, Z., Stone, J. J. Cereb. Blood Flow Metab. (2005) [Pubmed]
  7. 1,2-Benzisothiazol-3-one 1,1-dioxide inhibitors of human mast cell tryptase. Combrink, K.D., Gülgeze, H.B., Meanwell, N.A., Pearce, B.C., Zulan, P., Bisacchi, G.S., Roberts, D.G., Stanley, P., Seiler, S.M. J. Med. Chem. (1998) [Pubmed]
  8. Lymphocyte transformation test for diagnosis of isothiazolinone allergy in man. Stejskal, V.D., Forsbeck, M., Nilsson, R. J. Invest. Dermatol. (1990) [Pubmed]
  9. Occupational allergic contact dermatitis caused by 1,2-benzisothiazolin-3-one in a varnish maker, followed by sensitization to benzalkonium chloride in Oilatum Plus bath additive. Walker, S.L., Yell, J.A., Beck, M.H. Contact Derm. (2004) [Pubmed]
  10. Assessment of the relative skin sensitizing potency of 3 biocides using the murine local lymph node assay. Botham, P.A., Hilton, J., Evans, C.D., Lees, D., Hall, T.J. Contact Derm. (1991) [Pubmed]
  11. Occupational asthma and rhinitis caused by 1,2-benzisothiazolin-3-one in a chemical worker. Moscato, G., Omodeo, P., Dellabianca, A., Colli, M.C., Pugliese, F., Locatelli, C., Scibilia, J. Occupational medicine (Oxford, England) (1997) [Pubmed]
  12. Biological studies on 1,2-benzisothiazole derivatives V. Antimicrobial properties of N-alkanoic, N-arylalkanoic and N-aryloxyalkanoic derivatives of 1,2-benzisothiazolin-3-one: QSAR study and genotoxicity evaluation. Mor, M., Zani, F., Mazza, P., Silva, C., Bordi, F., Morini, G., Plazzi, P.V. Farmaco (1996) [Pubmed]
  13. On the short carbonyl bond in bis[mu-1,2-benzisothiazol-3(2H)-one 1,1-dioxido-kappa2N:O]bis[[1,2-benzisothiazol-3(2H)-one 1,1-dioxido-kappaN]bis(imidazole)copper(II)]. Naumov, P., Jovanovski, G., Hu, S.Z., Suh, I.H., Razak, I.A., Chantrapromma, S., Fun, H.K., Ng, S.W. Acta crystallographica. Section C, Crystal structure communications. (2001) [Pubmed]
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