Disease relevance of Leucomyosuppressin

• Neurons in the hypocerebral ganglion of horn fly, Hematobia irritans (L.), and stable fly, Stomoxys calcitrans (L.), were found to contain material immunoreactive to antiserum produced against the C-terminal of leucomyosuppressin, but not to the N-terminal of dromyossuppressin [1].

Psychiatry related information on Leucomyosuppressin

• Thus, leucomyosuppressin might play a role in the circadian system other than in the control of locomotor activity rhythms [2].

High impact information on Leucomyosuppressin

• Dromyosuppressin shares a high degree of sequence homology with leucomyosuppressin isolated from cockroach (pEDVDHVFLRFamide) and identity with neomyosuppressin isolated from fleshfly [3].
• The cDNA for leucomyosuppressin in Blattella germanica and molecular evolution of insect myosuppressins [4].
• Identification of leucomyosuppressin in the German cockroach, Blattella germanica, as an inhibitor of food intake [5].
• The muscular contractions of the midgut of the cockroach, Diploptera punctata: effects of the insect neuropeptides proctolin and leucomyosuppressin [6].
• Hindgut contractions spontaneously restarted in 10(-6) mol l-1 LMS, but only washing out LMS restored activity in oviducts [7].

Anatomical context of Leucomyosuppressin

• LMS depressed contractile activity in oviducts at concentrations above 10(-12) mol l-1, but hindguts did not respond to concentrations below 10(-6) mol l-1 [7].
• Leucomyosuppressin, a novel insect neuropeptide, inhibits evoked transmitter release at the mealworm neuromuscular junction [8].
• Two large lateral clusters containing 8 cells, linked dorsally and ventrally by 2 chains of 6 cells, encircled the anterior surface of the proventriculus and were immunoreactive of leucomyosuppressin and FMRFamide antisera [1].
• Localization of leucomyosuppressin-like peptides in the central nervous system of the stable fly with immunocytochemistry [9].

Analytical, diagnostic and therapeutic context of Leucomyosuppressin

• In situ hybridization analysis of leucomyosuppressin mRNA expression in the cockroach, Diploptera punctata [10].
• Through HPLC purification and sequence analysis, we obtained the peptide leucomyosuppressin (LMS): pQDVDHVFLRFamide [5].
• Immunocytochemistry was used to determine sites of synthesis and pathways for the transport of the neuropeptide, Leucomyosuppressin (pQDVDHVFLRFamide) in the cockroach, Leucophaea maderae [11].
• Immunohistochemistry and HPLC coupled to radioimmunoassay indicates that leucomyosuppressin represents a significant proportion of FMRFamide-related peptide production in the brain [12].

References