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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
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Disease relevance of Luteinization

  • Studies of ovarian histopathology in 26 transsexual subjects after long term androgen treatment revealed multiple cystic follicles in 18 subjects (69.2%), diffuse ovarian stromal hyperplasia in 21 subjects (80.8%), collagenization of the tunica albuginea in 25 subjects (96.2%), and luteinization of stromal cells in 7 subjects (26.9%) [1].
  • We speculate that ET-1, possibly of intraovarian origin, acts as a luteinization-inhibitor to suppress premature luteinization at a time when continued preovulatory expression of ET-1 (in the intact but not ruptured follicle) may be contingent upon relative intrafollicular hypoxia [2].
  • OBJECTIVE: To investigate the effect of induced endogenous hyperprolactinemia on the luteinization process, as expressed by the shift in the P:E2 ratio after hCG injection in IVF cycles [3].
  • The GnRH-induced LH surge appears to stimulate luteinization of the ovarian cyst wall [4].
  • Thus, a large follicle anovulatory condition, similar to follicular cysts, can be induced by estradiol induction of a GnRH/LH surge in the absence of subsequent luteinization, and this condition prevents a GnRH/LH surge in response to high doses of estradiol [5].

High impact information on Luteinization


Chemical compound and disease context of Luteinization


Biological context of Luteinization


Anatomical context of Luteinization

  • Furthermore, when PO + hCG (7 h) follicles were isolated and incubated for 1-3 h with reversible inhibitors of transcription (actinomycin-D) or translation (cycloheximide) before harvesting the granulosa cells, neither morphological nor functional luteinization of granulosa cells in culture was impaired [16].
  • Morphological examination of the ovary of PDE4D-/- mice indicated luteinization of antral follicles with entrapped oocytes [17].
  • The correlation between follicular fluid steroid and PP12 levels and the findings by immunoperoxidase staining suggest that PP12 is related to endocrine phenomena of the ovary, possibly to the luteinization process [18].
  • In the menstrual and pregnant CL, ECE-1 was highly expressed on both large and small luteal cells, indicating that ECE-1 expression increases during luteinization [19].
  • RNA isolated from ovaries with follicles at the preantral, preovulatory stage and from corpora lutea contained decreased tropomyosin mRNA levels during ovarian luteinization when the level of RNA for a key steroidogenic enzyme, cytochrome P-450 cholesterol side chain cleavage (P-450 scc), increased [20].

Associations of Luteinization with chemical compounds

  • The observed STC1 suppression of progesterone, but not estradiol, production further suggests the potential role of this paracrine hormone as a luteinization inhibitor [21].
  • Hormonal regulation of luteinizing hormone/chorionic gonadotropin receptor mRNA in rat ovarian cells during follicular development and luteinization [22].
  • The interactions of peptide and steroid hormone signaling cascades in the ovary are critical for follicular growth, ovulation, and luteinization [23].
  • Thus, acute elevation of serum androgen/estrogen ratios in vivo during follicular maturation was detrimental to the gametogenic functions of the primate follicle, but did not alter follicular growth, events of early luteinization, or subsequent luteal function.(ABSTRACT TRUNCATED AT 400 WORDS)[24]
  • The results of this exploratory study provide evidence that mifepristone is effective for the prevention of premature LH surges and/or premature luteinization in women undergoing COH for in vitro fertilization [25].

Gene context of Luteinization

  • Rather PRL activation of Stat5, principally Stat5b, occurred in association with luteinization [26].
  • These features result in a failure of the normal maturational events leading to successful ovulation and luteinization and presumably involve both hypothalamic-pituitary and intraovarian mechanisms dependent upon ER alpha action [27].
  • In these rats, luteinization occurred spontaneously without cervical stimulation, probably due to high levels of serum hGH, which has prolactin (PRL)-like activity in the rat [28].
  • Time-course experiments showed that only 2 days of forskolin treatment could induce PKC-responsiveness of the Cox-2 promoter, although maximal responsiveness was not observed until 10 days of luteinization [29].
  • Following a hCG stimulus, MMP-2 mRNA increased as the granulosa cells of preovulatory follicles underwent luteinization during formation of the corpus luteum (CL) [30].

Analytical, diagnostic and therapeutic context of Luteinization


  1. The effects of long term testosterone administration on pulsatile luteinizing hormone secretion and on ovarian histology in eugonadal female to male transsexual subjects. Spinder, T., Spijkstra, J.J., van den Tweel, J.G., Burger, C.W., van Kessel, H., Hompes, P.G., Gooren, L.J. J. Clin. Endocrinol. Metab. (1989) [Pubmed]
  2. Endothelin-1 as a luteinization inhibitor: inhibition of rat granulosa cell progesterone accumulation via selective modulation of key steroidogenic steps affecting both progesterone formation and degradation. Tedeschi, C., Hazum, E., Kokia, E., Ricciarelli, E., Adashi, E.Y., Payne, D.W. Endocrinology (1992) [Pubmed]
  3. Effects of induced hyperprolactinemia on in vitro fertilization cycles. Piekos, M.W., Binor, Z., Rawlins, R.G., Radwanska, E. Fertil. Steril. (1995) [Pubmed]
  4. Ovarian cysts in dairy cattle: a review. Kesler, D.J., Garverick, H.A. J. Anim. Sci. (1982) [Pubmed]
  5. A GnRH/LH surge without subsequent progesterone exposure can induce development of follicular cysts. Gümen, A., Sartori, R., Costa, F.M., Wiltbank, M.C. J. Dairy Sci. (2002) [Pubmed]
  6. The oxytocin receptor system: structure, function, and regulation. Gimpl, G., Fahrenholz, F. Physiol. Rev. (2001) [Pubmed]
  7. Time of implantation of the conceptus and loss of pregnancy. Wilcox, A.J., Baird, D.D., Weinberg, C.R. N. Engl. J. Med. (1999) [Pubmed]
  8. Gonadotropin receptors in experimentally induced ovarian tumors in mice. Kammerman, S., Demopoulos, R.I., Ross, J. Cancer Res. (1977) [Pubmed]
  9. Bone morphogenetic protein-15 inhibits follicle-stimulating hormone (FSH) action by suppressing FSH receptor expression. Otsuka, F., Yamamoto, S., Erickson, G.F., Shimasaki, S. J. Biol. Chem. (2001) [Pubmed]
  10. Comparison of pregnenolone synthesis by cytochrome P-450scc in mitochondria from porcine corpora lutea and granulosa cells of follicles. Tuckey, R.C., Holland, J.W. J. Biol. Chem. (1989) [Pubmed]
  11. Porcine follicular fluid treatment at proestrus diminishes the serum progesterone level of rats in early pregnancy. Guoth, J., Varga, B. Acta physiologica Hungarica. (1985) [Pubmed]
  12. Endogenous luteinizing hormone surge during superovulation induction with sequential use of clomiphene citrate and pulsatile human menopausal gonadotropin. Messinis, I.E., Templeton, A., Baird, D.T. J. Clin. Endocrinol. Metab. (1985) [Pubmed]
  13. Gonadotropin-induced up- and down-regulation of rat ovarian LH receptor message levels during follicular growth, ovulation and luteinization. LaPolt, P.S., Oikawa, M., Jia, X.C., Dargan, C., Hsueh, A.J. Endocrinology (1990) [Pubmed]
  14. Dynamics of Myc/Max/Mad expression during luteinization of primate granulosa cells in vitro: association with periovulatory proliferation. Chaffin, C.L., Brogan, R.S., Stouffer, R.L., VandeVoort, C.A. Endocrinology (2003) [Pubmed]
  15. Role of tumor necrosis factor in preovulatory follicles of swine. Prange-Kiel, J., Kreutzkamm, C., Wehrenberg, U., Rune, G.M. Biol. Reprod. (2001) [Pubmed]
  16. Aromatase cytochrome P450 in rat ovarian granulosa cells before and after luteinization: adenosine 3',5'-monophosphate-dependent and independent regulation. Cloning and sequencing of rat aromatase cDNA and 5' genomic DNA. Hickey, G.J., Krasnow, J.S., Beattie, W.G., Richards, J.S. Mol. Endocrinol. (1990) [Pubmed]
  17. Phosphodiesterase regulation is critical for the differentiation and pattern of gene expression in granulosa cells of the ovarian follicle. Park, J.Y., Richard, F., Chun, S.Y., Park, J.H., Law, E., Horner, K., Jin, S.L., Conti, M. Mol. Endocrinol. (2003) [Pubmed]
  18. Human preovulatory follicular fluid, luteinized cells of hyperstimulated preovulatory follicles, and corpus luteum contain placental protein 12. Seppälä, M., Wahlström, T., Koskimies, A.I., Tenhunen, A., Rutanen, E.M., Koistinen, R., Huhtaniemi, I., Bohn, H., Stenman, U.H. J. Clin. Endocrinol. Metab. (1984) [Pubmed]
  19. Endothelin-converting enzyme-1 is expressed on human ovarian follicles and corpora lutea of menstrual cycle and early pregnancy. Yoshioka, S., Fujiwara, H., Yamada, S., Tatsumi, K., Nakayama, T., Higuchi, T., Inoue, T., Maeda, M., Fujii, S. J. Clin. Endocrinol. Metab. (1998) [Pubmed]
  20. Regulation of tropomyosin expression in the maturing ovary and in primary granulosa cell cultures. Ben-Ze'ev, A., Baum, G., Amsterdam, A. Dev. Biol. (1989) [Pubmed]
  21. Paracrine regulation of ovarian granulosa cell differentiation by stanniocalcin (STC) 1: mediation through specific STC1 receptors. Luo, C.W., Kawamura, K., Klein, C., Hsueh, A.J. Mol. Endocrinol. (2004) [Pubmed]
  22. Hormonal regulation of luteinizing hormone/chorionic gonadotropin receptor mRNA in rat ovarian cells during follicular development and luteinization. Segaloff, D.L., Wang, H.Y., Richards, J.S. Mol. Endocrinol. (1990) [Pubmed]
  23. Novel signaling pathways that control ovarian follicular development, ovulation, and luteinization. Richards, J.S., Russell, D.L., Ochsner, S., Hsieh, M., Doyle, K.H., Falender, A.E., Lo, Y.K., Sharma, S.C. Recent Prog. Horm. Res. (2002) [Pubmed]
  24. Administration of an aromatase inhibitor during the late follicular phase of gonadotropin-treated cycles in rhesus monkeys: effects on follicle development, oocyte maturation, and subsequent luteal function. Zelinski-Wooten, M.B., Hess, D.L., Baughman, W.L., Molskness, T.A., Wolf, D.P., Stouffer, R.L. J. Clin. Endocrinol. Metab. (1993) [Pubmed]
  25. Mifepristone is an effective oral alternative for the prevention of premature luteinizing hormone surges and/or premature luteinization in women undergoing controlled ovarian hyperstimulation for in vitro fertilization. Escudero, E.L., Boerrigter, P.J., Bennink, H.J., Epifanio, R., Horcajadas, J.A., Olivennes, F., Pellicer, A., Simón, C. J. Clin. Endocrinol. Metab. (2005) [Pubmed]
  26. Differentiation-dependent prolactin responsiveness and stat (signal transducers and activators of transcription) signaling in rat ovarian cells. Russell, D.L., Richards, J.S. Mol. Endocrinol. (1999) [Pubmed]
  27. Targeted disruption of the estrogen receptor-alpha gene in female mice: characterization of ovarian responses and phenotype in the adult. Schomberg, D.W., Couse, J.F., Mukherjee, A., Lubahn, D.B., Sar, M., Mayo, K.E., Korach, K.S. Endocrinology (1999) [Pubmed]
  28. Different female reproductive phenotypes determined by human growth hormone (hGH) levels in hGH-transgenic rats. Ikeda, A., Matsumoto, Y., Chang, K.T., Nakano, T., Matsuyama, S., Yamanouchi, K., Ohta, A., Nishihara, M., Tojo, H., Sasaki, F., Takahashi, M. Biol. Reprod. (1997) [Pubmed]
  29. Transcriptional regulation of the cyclooxygenase-2 gene changes from protein kinase (PK) A- to PKC-dependence after luteinization of granulosa cells. Wu, Y.L., Wiltbank, M.C. Biol. Reprod. (2002) [Pubmed]
  30. Cellular localization of gelatinases and tissue inhibitors of metalloproteinases during follicular growth, ovulation, and early luteal formation in the rat. Curry, T.E., Song, L., Wheeler, S.E. Biol. Reprod. (2001) [Pubmed]
  31. In situ hybridization of high density lipoprotein (scavenger, type 1) receptor messenger ribonucleic acid (mRNA) during folliculogenesis and luteinization: evidence for mRNA expression and induction by human chorionic gonadotropin specifically in cell types that use cholesterol for steroidogenesis. Li, X., Peegel, H., Menon, K.M. Endocrinology (1998) [Pubmed]
  32. Regulated expression of sterol carrier protein 2 in the ovary: a key role for cyclic AMP. Rennert, H., Amsterdam, A., Billheimer, J.T., Strauss, J.F. Biochemistry (1991) [Pubmed]
  33. Growth factor modulation of steroidogenic acute regulatory protein and luteinization in the pig ovary. Pescador, N., Stocco, D.M., Murphy, B.D. Biol. Reprod. (1999) [Pubmed]
  34. Oxytocin and progesterone secretion by bovine granulosa cells of individual preovulatory follicles cultured in serum-free medium. Shukovski, L., Fortune, J.E., Findlay, J.K. Mol. Cell. Endocrinol. (1990) [Pubmed]
  35. Granulosa theca cell tumors in premenarchal girls: a clinical and pathologic study of ten cases. Lack, E.E., Perez-Atayde, A.R., Murthy, A.S., Goldstein, D.P., Crigler, J.F., Vawter, G.F. Cancer (1981) [Pubmed]
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