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Chemical Compound Review

CYCLIC CMP     4-amino-1-[(1S,6R,8R,9R)-3,9- dihydroxy-3...

Synonyms: CHEMBL72442, SureCN1331888, Cyclic CMP, 7, CHEBI:17065, AC1L2DQL, ...
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Disease relevance of CYCLIC CMP


High impact information on CYCLIC CMP


Biological context of CYCLIC CMP

  • These findings suggest that the depressed cyclic CMP phosphodiesterase activity (hence, the elevated cyclic CMP concentration) is perhaps a common factor in developing tissues undergoing rapid cell proliferation [3].
  • Cyclic CMP in concentrations between 0.35 to 1.5 mM progressively decreased the RNA labelling, and the values of the PCA soluble radioactivity again followed those of RNA [6].

Anatomical context of CYCLIC CMP


Associations of CYCLIC CMP with other chemical compounds

  • Incubation of ribonuclease with 0.1M mercaptoethanol at pH 8.5 can increase the enzyme's hydrolytic activity toward cytidine 2',3'-monophosphate (cyclic CMP) under standard assay conditions [2].
  • These findings suggest that depressed cyclic CMP phosphodiesterase may be in part related to cell proliferation, in line with reports that the regenerating liver has higher levels of cyclic CMP (Bloch, A. (1975) Adv. Cycli Nucleotide Res. 5, 331-338) and cytidylate cyclase (Cech, S. Y., and Ignarro, L.J. (1977) Science 198, 1063-1065) [9].

Gene context of CYCLIC CMP

  • Here a modified RIA protocol, in which the production of assay components has been optimized and a novel trilayer chromatography column separation introduced which successfully separates cyclic CMP from compounds, endogenous to living tissues, which cross-react with anti-cyclic CMP sera, is described [10].

Analytical, diagnostic and therapeutic context of CYCLIC CMP


  1. Decreased activity of cytidine 3':5'-monophosphate (cyclic CMP) phosphodiesterase in the fast-growing Morris hepatoma 3924A, but not in the slow-growing Morris hepatoma 9618A. Shoji, M., Brackett, N.L., Helfman, D.M., Morris, H.P., Kuo, J.F. Biochem. Biophys. Res. Commun. (1978) [Pubmed]
  2. Enhancement of bovine pancreatic ribonuclease activity by mercaptoethanol. Watkins, J.B., Benz, F.W. Science (1978) [Pubmed]
  3. Depression of cytidine 3':5'-cyclic monophosphate phosphodiesterase activity in developing tissues of guinea pigs. Helfman, D.M., Brackett, N.L., Kuo, J.F. Proc. Natl. Acad. Sci. U.S.A. (1978) [Pubmed]
  4. Relationship between the levels of cyclic cytidine 3':5'-monophosphate, cyclic guanosine 3':5'-monophosphate, and cyclic adenosine 3':5'-monophosphate in urines and leukocytes and the type of human leukemias. Scavennec, J., Carcassonne, Y., Gastaut, J.A., Blanc, A., Cailla, H.L. Cancer Res. (1981) [Pubmed]
  5. A homogeneous cyclic CMP phosphodiesterase hydrolyzes both pyrimidine and purine cyclic 2':3'- and 3':5'-nucleotides. Helfman, D.M., Kuo, J.F. J. Biol. Chem. (1982) [Pubmed]
  6. Action of cyclic nucleotides on protein and RNA synthesis in the thyroid. Pisarev, M.A., de Pisarev, D.L. Acta Endocrinol. (1977) [Pubmed]
  7. Lysosomal enzyme secretion from human neutrophils mediated by cyclic CMP: inhibition of cyclic GMP accumulation and neutrophil function by glucocorticosteroids. Ignarro, L.J., Cech, S.Y. Journal of cyclic nucleotide research. (1975) [Pubmed]
  8. Cyclic nucleotides and the control of epithelial cell proliferation: cyclic CMP may be a partial mediator of the response of the pigeon crop-sac to prolactin. Anderson, T.R., Mayer, G.L., Nicoll, C.S. Journal of cyclic nucleotide research. (1981) [Pubmed]
  9. Cytidine 3':5'-monophosphate phosphodiesterase in mammalian tissues. Occurrence and biological involvement. Kuo, J.F., Brackett, N.L., Shoji, M., Tse, J. J. Biol. Chem. (1978) [Pubmed]
  10. Radioimmunoassay of cytidine 3',5'-cyclic monophosphate: unambiguous assay by means of an optimized protocol incorporating a trilayer column separation to obviate cross-reactivity problems. Newton, R.P., Evans, A.M., van Geyschem, J., Diffley, P.J., Hassam, H.G., Hakeem, N.A., Moyse, C.D., Cooke, R., Salvage, B.J. Journal of immunoassay. (1994) [Pubmed]
  11. Extraction, purification and identification of cytidine 3',5'-cyclic monophosphate from rat tissues. Newton, R.P., Salih, S.G., Salvage, B.J., Kingston, E.E. Biochem. J. (1984) [Pubmed]
  12. Enzyme immunoassay for cytidine 3',5'-cyclic monophosphate (cyclic CMP). Yamamoto, I., Takai, T., Tsuji, J. Immunopharmacology (1982) [Pubmed]
  13. A practically sensitive radioimmunoassay for cyclic CMP by 2'-O-acetylation. Sato, T., Kuninaka, A., Yoshino, H. Anal. Biochem. (1982) [Pubmed]
  14. Kinetic analysis of cyclic CMP-specific and multifunctional phosphodiesterases by quantitative positive-ion fast-atom bombardment mass spectrometry. Newton, R.P., Bayliss, M.A., Khan, J.A., Bastani, A., Wilkins, A.C., Games, D.E., Walton, T.J., Brenton, A.G., Harris, F.M. Rapid Commun. Mass Spectrom. (1999) [Pubmed]
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