The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

Albaconazol     7-chloro-3-[(2R,3R)-3-(2,4- difluorophenyl)...

Synonyms: ALBACONAZOLE, CHEMBL298817, AG-K-08936, SureCN1262830, UR-9825, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Albaconazol

  • Furthermore, the parasitological, PCR, serological, and proliferative assay results indicated parasitological cure indices of 25 and 100% among animals inoculated with T. cruzi strain Y when they were treated with albaconazole at 1.5 mg/kg of body weight/day for 60 and 90 days, respectively [1].
  • Despite limited penetration into the subarachnoid space, at all three doses tested albaconazole was as effective as fluconazole for the treatment of cryptococcal meningitis in rabbits [2].
  • The 7-Cl derivative, (1R,2R)-7-chloro-3-[2-(2, 4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2, 4-triazol-1-yl)propyl]quinazolin-4(3H)-one (20, UR-9825), was selected for further testing due to its high in vitro activity, low toxicity, good pharmacokinetic profile, and ease of obtention [3].

High impact information on Albaconazol

  • Activity of the new triazole derivative albaconazole against Trypanosoma (Schizotrypanum) cruzi in dog hosts [1].
  • The peak concentrations of albaconazole in serum and cerebrospinal fluid (CSF) averaged 4.14 and 0.62 micro g/ml, respectively, in animals receiving 80 mg/kg/day [2].
  • In conclusion, our results demonstrate that albaconazole has trypanocidal activity in vivo and is capable of inducing radical parasitological cure, although natural resistance to this compound was also indicated [1].
  • Low growth-inhibitory antifungal activities were found in vitro for most of the drugs tested against S. prolificans isolates, with the MICs at which 90% of isolates are inhibited (MIC(90)s) being >8 microg/ml; the MIC(90)s of voriconazole and UR-9825, however, were 4 microg/ml [4].
  • The clinically relevant intracellular amastigote form, grown in cultured Vero cells at 37 degrees C, was even more sensitive to UR-9825, with a MIC of 10 nM, comparable to that for ketoconazole [5].

Chemical compound and disease context of Albaconazol


Associations of Albaconazol with other chemical compounds


  1. Activity of the new triazole derivative albaconazole against Trypanosoma (Schizotrypanum) cruzi in dog hosts. Guedes, P.M., Urbina, J.A., de Lana, M., Afonso, L.C., Veloso, V.M., Tafuri, W.L., Machado-Coelho, G.L., Chiari, E., Bahia, M.T. Antimicrob. Agents Chemother. (2004) [Pubmed]
  2. In vitro and in vivo efficacies of the new triazole albaconazole against Cryptococcus neoformans. Miller, J.L., Schell, W.A., Wills, E.A., Toffaletti, D.L., Boyce, M., Benjamin, D.K., Bartroli, J., Perfect, J.R. Antimicrob. Agents Chemother. (2004) [Pubmed]
  3. New azole antifungals. 3. Synthesis and antifungal activity of 3-substituted-4(3H)-quinazolinones. Bartroli, J., Turmo, E., Algueró, M., Boncompte, E., Vericat, M.L., Conte, L., Ramis, J., Merlos, M., García-Rafanell, J., Forn, J. J. Med. Chem. (1998) [Pubmed]
  4. In vitro activities of new and conventional antifungal agents against clinical Scedosporium isolates. Meletiadis, J., Meis, J.F., Mouton, J.W., Rodriquez-Tudela, J.L., Donnelly, J.P., Verweij, P.E. Antimicrob. Agents Chemother. (2002) [Pubmed]
  5. In vitro antiproliferative effects and mechanism of action of the new triazole derivative UR-9825 against the protozoan parasite Trypanosoma (Schizotrypanum) cruzi. Urbina, J.A., Lira, R., Visbal, G., Bartrolí, J. Antimicrob. Agents Chemother. (2000) [Pubmed]
  6. Efficacy of albaconazole (UR-9825) in treatment of disseminated Scedosporium prolificans infection in rabbits. Capilla, J., Yustes, C., Mayayo, E., Fernández, B., Ortoneda, M., Pastor, F.J., Guarro, J. Antimicrob. Agents Chemother. (2003) [Pubmed]
  7. In-vitro comparative activity of UR-9825, itraconazole and fluconazole against clinical isolates of Candida spp. Ramos, G., Cuenca-Estrella, M., Monzón, A., Rodríguez-Tudela, J.L. J. Antimicrob. Chemother. (1999) [Pubmed]
  8. Cutaneous infection caused by Aspergillus ustus, an emerging opportunistic fungus in immunosuppressed patients. Gené, J., Azón-Masoliver, A., Guarro, J., De Febrer, G., Martínez, A., Grau, C., Ortoneda, M., Ballester, F. J. Clin. Microbiol. (2001) [Pubmed]
  9. In vitro activities of new and conventional antimycotics against fluconazole-susceptible and non-susceptible Brazilian Candida spp. isolates. Alves, S.H., Da Matta, D.A., Azevedo, A.C., Loreto, E.S., Boff, E., Santurio, J.M., Guarro, J. Mycoses (2006) [Pubmed]
  10. In vitro susceptibilities of 11 clinical isolates of Exophiala species to six antifungal drugs. Meletiadis, J., Meis, J.F., de Hoog, G.S., Verweij, P.E. Mycoses (2000) [Pubmed]
WikiGenes - Universities