Disease relevance of alexidine

• Alkyl agents alexidine, heptihexidine (1,6-bis-n-heptylbiguanidohexane), hexoctidine (1,8-bis-n-hexylbiguanidoctane), and hexhexidine (1,6-bis-n-hexylbiguanidohexane), as well as chlorhexidine, were active against Actinobacillus actinomycetemcomitans, a Gram-negative organism associated with localized juvenile periodontitis [1].
• The effect of an alexidine mouthwash on plaque and gingivitis [2].
• Tea added to the culture increased the MIC values against E. coli for alexidine, chlorhexidine and hexetidine, but not for cetyl pyridinium chloride [3].
• Inhibitory effects of an alexidine mouthrinse on dental plaque formation [4].
• Strains of Providencia stuartii with demonstrated resistance towards chlorhexidine did not show such resistance towards either of the related biguanide antiseptics, alexidine or vantocil [5].

High impact information on alexidine

• Tetracycline, alexidine, and SnF2 were bactericidal in vitro in all bacteria tested at concentrations lower than those used clinically [6].
• Although at the concentrations used alexidine was less effective than chlorhexidine, it may be of value as a short-term adjunct to oral hygiene [7].
• Comparison of the in vivo and in vitro antibacterial properties of antiseptic mouthrinses containing chlorhexidine, alexidine, cetyl pyridinium chloride and hexetidine. Relevance to mode of action [8].
• Whilst overall bactericidal activities and MICs were similar, alexidine was more rapid in its action and it is suggested that (1) it might possess additional targets at the cell envelope to chlorhexidine, and (2) the nature of the interaction at the cytoplasmic membrane for the two compounds differs [9].

Chemical compound and disease context of alexidine

• The effectiveness of an antimicrobial mouthwash (alexidine, 2-ethylhexyl bisbiguanidine dihydrochloride) in preventing plaque and gingivitis was evaluated in 45 young male adults [10].

Analytical, diagnostic and therapeutic context of alexidine

• The alexidine mouthrinse significantly reduced the plaque index when used in conjunction with toothbrushing and also when brushing was discontinued [2].
• Significant and comparable reductions in salivary bacterial counts were observed with both chlorhexidine and alexidine on day 4 and day 10 when compared with pre-rinse counts [7].
• Differential thermal analysis of various mixed lipid vesicles and pure phospholipid vesicles showed alexidine to share with vantocil the property of producing lipid phase separation and domain formation [5].

References