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Chemical Compound Review

Alexidina     1-[N'-[6-[[amino-[(N'-(2...

Synonyms: alexidine, Alexidinum, Bisguadine, Bisguanidine, Compound 904, ...
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Disease relevance of alexidine


High impact information on alexidine


Chemical compound and disease context of alexidine


Analytical, diagnostic and therapeutic context of alexidine

  • The alexidine mouthrinse significantly reduced the plaque index when used in conjunction with toothbrushing and also when brushing was discontinued [2].
  • Significant and comparable reductions in salivary bacterial counts were observed with both chlorhexidine and alexidine on day 4 and day 10 when compared with pre-rinse counts [7].
  • Differential thermal analysis of various mixed lipid vesicles and pure phospholipid vesicles showed alexidine to share with vantocil the property of producing lipid phase separation and domain formation [5].


  1. Structural determinants of activity of chlorhexidine and alkyl bisbiguanides against the human oral flora. Baker, P.J., Coburn, R.A., Genco, R.J., Evans, R.T. J. Dent. Res. (1987) [Pubmed]
  2. The effect of an alexidine mouthwash on plaque and gingivitis. Formicola, A.J., Deasy, M.J., Graessle, O.E., Johnson, D.H., Howe, E.E. J. Periodontol. (1978) [Pubmed]
  3. The effect of surface adsorption and staining reactions on the antimicrobial properties of some cationic antiseptic mouthwashes. Moran, J., Addy, M. J. Periodontol. (1984) [Pubmed]
  4. Inhibitory effects of an alexidine mouthrinse on dental plaque formation. Deasy, M.J., Formicola, A.J., Johnson, D.H., Howe, E.E. Clinical preventive dentistry. (1979) [Pubmed]
  5. Interaction of the bisbiguanides chlorhexidine and alexidine with phospholipid vesicles: evidence for separate modes of action. Chawner, J.A., Gilbert, P. J. Appl. Bacteriol. (1989) [Pubmed]
  6. Effect of Chinese and western antimicrobial agents on selected oral bacteria. Tsao, T.F., Newman, M.G., Kwok, Y.Y., Horikoshi, A.K. J. Dent. Res. (1982) [Pubmed]
  7. Comparison of the bisbiguanide antiseptics alexidine and chlorhexidine. I. Effect on plaque accumulation and salivary bacteria. Roberts, W.R., Addy, M. Journal of clinical periodontology. (1981) [Pubmed]
  8. Comparison of the in vivo and in vitro antibacterial properties of antiseptic mouthrinses containing chlorhexidine, alexidine, cetyl pyridinium chloride and hexetidine. Relevance to mode of action. Roberts, W.R., Addy, M. Journal of clinical periodontology. (1981) [Pubmed]
  9. A comparative study of the bactericidal and growth inhibitory activities of the bisbiguanides alexidine and chlorhexidine. Chawner, J.A., Gilbert, P. J. Appl. Bacteriol. (1989) [Pubmed]
  10. The effect of an antimicrobial mouthwash on dental plaque and gingivitis in yound adults. Spolsky, V.W., Bhatia, H.L., Forsythe, A., Levin, D. J. Periodontol. (1975) [Pubmed]
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