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Chemical Compound Review

Oraldene     1,3-bis(2-ethylhexyl)-5- methyl-1,3...

Synonyms: Glypesin, Sterisil, Drossadin, Hexoral, Hextril, ...
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Disease relevance of Hextril


High impact information on Hextril


Chemical compound and disease context of Hextril


Biological context of Hextril


Anatomical context of Hextril


Associations of Hextril with other chemical compounds


Gene context of Hextril

  • This study was designed to investigate the effectiveness of mouthwashes containing hexetidine/zinc (HZA) or tin (ASF) in inhibiting plaque formation and gingivitis in humans [17].

Analytical, diagnostic and therapeutic context of Hextril

  • All antiseptics were effective at low concentrations against the organisms tested but the minimum inhibitory concentration values for hexetidine were the highest [15].
  • The aim of the present study was to determine the effects of a 0.2% hexetidine spray, used as a supplement to regular oral hygiene measures, on dental plaque and gingival condition following periodontal surgery [3].
  • The HPLC assay was sufficiently sensitive to accurately detect hexetidine in saliva up to 25 min after in-vivo use of a commercial oral rinse [12].
  • Hexetidine reduced aerobic bacterial counts on Day 1 and Day 8 by a maximum of 83% and 86%, respectively, at 2 minutes post-dosing [18].
  • A double-blind crossover study on 4 adult volunteers was performed to evaluate the effect of hexetidine on Cu2+ accumulation in dental plaque as well as a possible enhanced effect of copper on inhibition of acid production in the presence of hexetidine [19].


  1. Influence of hexetidine upon plaque and gingivitis in the beagle dog. McDonald, J.L., Schemehorn, B.R., Stookey, G.K. J. Dent. Res. (1978) [Pubmed]
  2. Synergistic inhibitory effect of zinc and hexetidine on in vitro growth and acid production of Streptococcus mutans. Moermann, J.E., Muehlemann, H.R. J. Dent. Res. (1983) [Pubmed]
  3. The effect of hexetidine spray on dental plaque following periodontal surgery. Bokor, M. Journal of clinical periodontology. (1996) [Pubmed]
  4. Fluconazole and/or hexetidine for management of oral candidiasis associated with denture-induced stomatitis. Koray, M., Ak, G., Kurklu, E., Issever, H., Tanyeri, H., Kulekci, G., Guc, U. Oral diseases. (2005) [Pubmed]
  5. Fluconazole and/or hexetidine for management of oral candidiasis associated with denture-induced stomatitis. Agha-Hosseini, F. Oral diseases. (2006) [Pubmed]
  6. The nitrosation of hexetidine and hexedine: characterization of the major nitrosamine from common antimicrobial agents. Bae, J.Y., Mende, P., Shevlin, G., Spiegelhalder, B., Preussmann, R., Loeppky, R.N. Chem. Res. Toxicol. (1994) [Pubmed]
  7. The effects of hexetidine (Oraldene) on the adherence of Candida albicans to human buccal epithelial cells in vitro and ex vivo and on in vitro morphogenesis. Jones, D.S., McGovern, J.G., Woolfson, A.D., Gorman, S.P. Pharm. Res. (1997) [Pubmed]
  8. Uncoupling of mitochondrial oxidative phosphorylation by hexetidine. D'Arcangelo, G., Barile, M., Passarella, S., Quagliariello, E. Biochem. Biophys. Res. Commun. (1987) [Pubmed]
  9. The effect of surface adsorption and staining reactions on the antimicrobial properties of some cationic antiseptic mouthwashes. Moran, J., Addy, M. J. Periodontol. (1984) [Pubmed]
  10. Decontamination of the oral cavity. Effect of six local anti-microbial preparations in comparison to water and parafilm as controls. Matula, C., Hildebrandt, M., Nahler, G. J. Int. Med. Res. (1988) [Pubmed]
  11. Nitrosation of the antimicrobial drug hexetidine: nitrosamines derived from a triamine decomposition product. Mende, P., Wacker, C.D., Preussmann, R., Spiegelhalder, B. Food Chem. Toxicol. (1993) [Pubmed]
  12. Determination of the salivary retention of hexetidine in-vivo by high-performance liquid chromatography. McCoy, C.P., Jones, D.S., McGovern, J.G., Gorman, S.P., Woolfson, A.D. J. Pharm. Pharmacol. (2000) [Pubmed]
  13. Protective effect of hexetidine against in vitro bacterial demineralisation of bovine enamel and dentin in the presence of fluoride. Chmelarová, R., Van Loveren, C., Buijs, J.F., ten Cate, J.M. Caries Res. (1997) [Pubmed]
  14. Antiplaque and antigingivitis effectiveness of a hexetidine mouthwash. Sharma, N.C., Galustians, H.J., Qaqish, J., Charles, C.H., Vincent, J.W., McGuire, J.A. Journal of clinical periodontology. (2003) [Pubmed]
  15. Comparison of the in vivo and in vitro antibacterial properties of antiseptic mouthrinses containing chlorhexidine, alexidine, cetyl pyridinium chloride and hexetidine. Relevance to mode of action. Roberts, W.R., Addy, M. Journal of clinical periodontology. (1981) [Pubmed]
  16. Correlation between the in vivo and in vitro antimicrobial properties of commercially available mouthwash preparations. Moneib, N.A., el-Said, M.A., Shibl, A.M. Journal of chemotherapy (Florence, Italy) (1992) [Pubmed]
  17. The effect on early plaque formation, gingivitis and salivary bacterial counts of mouthwashes containing hexetidine/zinc, aminefluoride/tin or chlorhexidine. Hefti, A.F., Huber, B. Journal of clinical periodontology. (1987) [Pubmed]
  18. Hexetidine ('Oraldene'): a report on its antibacterial and antifungal properties on the oral flora in healthy subjects. Wile, D.B., Dinsdale, J.R., Joynson, D.H. Current medical research and opinion. (1986) [Pubmed]
  19. Effect of a combination of copper and hexetidine on the acidogenicity and copper accumulation in dental plaque in vivo. Grytten, J., Aamdal Scheie, A., Afseth, J. Caries Res. (1988) [Pubmed]
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