Disease relevance of Hextril

• Influence of hexetidine upon plaque and gingivitis in the beagle dog [1].
• Synergistic inhibitory effect of zinc and hexetidine on in vitro growth and acid production of Streptococcus mutans [2].
• The effect of hexetidine spray on dental plaque following periodontal surgery [3].
• Fluconazole and/or hexetidine for management of oral candidiasis associated with denture-induced stomatitis [4].
• Fluconazole and/or hexetidine for management of oral candidiasis associated with denture-induced stomatitis [5].

High impact information on Hextril

• The acidic nitrosation of hexetidine and hexedine, common antimicrobial agents and drug constituents, leads to a mixture of nitrosamines [6].
• The effects of hexetidine on morphogenesis were evaluated using light microscopy [7].
• The effects of hexetidine (Oraldene) on the adherence of Candida albicans to human buccal epithelial cells in vitro and ex vivo and on in vitro morphogenesis [7].
• The effects of hexetidine on yeast cell viability were both concentration and time-dependent [7].
• Uncoupling of mitochondrial oxidative phosphorylation by hexetidine [8].

Chemical compound and disease context of Hextril

• In both instances, hexetidine exerted no significant effect while 0.2% chlorhexidine resulted in reductions in both plaque and gingivitis of about 45 and 50%, respectively [1].
• The minimum inhibitory concentration (MIC) of commercial mouthrinses containing alexidine, cetyl pyridinium chloride, chlorhexidine gluconate and hexetidine against Oxford staphylococcus (NCTC 6571) and Escherichia coli (NCTC 10418) was established by tube dilution [9].
• A single rinse with either tyrothricin or hexetidine resulted in a significant reduction of aerobic and anaerobic bacteria in saliva which lasted for the whole 1 h observation period and was considerably more effective than hydrogen peroxide or ethanol [10].

Biological context of Hextril

• To gain further insight into the biochemical properties of the antibacterial hexetidine, isolated rat liver mitochondria were added with this drug and investigation made of certain features related to mitochondrial bioenergetics [8].
• PURPOSE: This study reports the effects of hexetidine (Oraldene) on two virulence attributes of Candida albicans, namely, in vitro and ex vivo adherence of yeast cells to buccal epithelial cells (BEC) and in vitro morphogenesis [7].
• Five new nitrosamines were identified as nitrosation products of N1,N3-bis(2-ethylhexyl)-2-methyl-1,2,3-propantriamine, a hydrolysis product usually found in preparations of the antimicrobial drug hexetidine [11].

Anatomical context of Hextril

• From these data a first-order elimination rate constant of hexetidine from the oral cavity was determined post-rinsing in each of six volunteers [12].
• Protective effect of hexetidine against in vitro bacterial demineralisation of bovine enamel and dentin in the presence of fluoride [13].

Associations of Hextril with other chemical compounds

• The nitrosation of hexetidine and hexedine: characterization of the major nitrosamine from common antimicrobial agents [6].
• Subjects were randomly assigned to one of three mouthwashes (hexetidine 0.1%, chlorhexidine 0.12% (positive control) or a 5% hydroalcohol negative control) and commenced three times daily supervised rinsing as their sole method of oral hygiene [14].
• Food extract and serum markedly increased the minimum inhibitory concentration values of all antiseptics, although alexidine and hexetidine were the least affected in percentage terms [15].
• The minimum inhibitory concentrations (MIC) for two of the studied mouthwashes (Corsodyl and Oraldene) against buccal organisms were determined in Todd Hewitt medium with or without 5% serum [16].

Gene context of Hextril

• This study was designed to investigate the effectiveness of mouthwashes containing hexetidine/zinc (HZA) or tin (ASF) in inhibiting plaque formation and gingivitis in humans [17].

Analytical, diagnostic and therapeutic context of Hextril

• All antiseptics were effective at low concentrations against the organisms tested but the minimum inhibitory concentration values for hexetidine were the highest [15].
• The aim of the present study was to determine the effects of a 0.2% hexetidine spray, used as a supplement to regular oral hygiene measures, on dental plaque and gingival condition following periodontal surgery [3].
• The HPLC assay was sufficiently sensitive to accurately detect hexetidine in saliva up to 25 min after in-vivo use of a commercial oral rinse [12].
• Hexetidine reduced aerobic bacterial counts on Day 1 and Day 8 by a maximum of 83% and 86%, respectively, at 2 minutes post-dosing [18].
• A double-blind crossover study on 4 adult volunteers was performed to evaluate the effect of hexetidine on Cu2+ accumulation in dental plaque as well as a possible enhanced effect of copper on inhibition of acid production in the presence of hexetidine [19].

References