Psychiatry related information on alpha-Methyl-p-tyrosine methyl ester

• A decrease in specific [3H]spiroperidol binding to rat caudate tissue and a parallel decrease in sensitivity to apomorphine in eliciting stereotyped behavior was observed in the offspring of rat mothers treated with either haloperidol or alpha-methyl-p-tyrosine-methyl ester during pregnancy [1].
• H 44/68 (200 mg/kg, i.p.) also increased motor activity during light, but in contrast to FLA 63 greatly reduced motor activity during darkness [2].

High impact information on alpha-Methyl-p-tyrosine methyl ester

• The effect of salbutamol treatment on brain catecholamine(CA) utilization was estimated by studying the disappearance of CA in the brain after inhibition of tyrosine hydroxylase by alpha-methyltyrosine methyl ester (H 44/68), 250 mg/kg IP, 3.5 h before sacrifice [3].
• A different time course response of brain and adrenal catecholamines to alpha-methyl-p-tyrosine methyl-ester (AMT) administration in normal rats was observed; the catecholamine turnover rate in adrenal glands appeared to be much slower than in the brain [4].
• The effects of the inhibitor of the tyrosine-hydroxylase H 44/68 and the inhibitor of the dopamine-beta-hydroxylase FLA 63 on the diurnal variations of the motor activity was studied in male Wistar rats, which were kept under standardized conditions of light and darkness (L:D = 12:12 h) [2].
• Catecholamine metabolism was determined by measuring the concentrations of NE and DA in the hypothalamus after catecholamine synthesis inhibition by alpha-methyl-p-tyrosine methyl-ester hydrochloride (200 mg/kg) [5].
• Nicotine significantly reduced serum prolactin and TSH levels, and after H 44/68 it also reduced LH and FSH serum levels [6].

Anatomical context of alpha-Methyl-p-tyrosine methyl ester

• The tyrosine-hydroxylase inhibitor, H 44/68, as well as reserpine and guanethidine, produced a more efficient reduction in neuronal noradrenaline in the heart and submandibular gland than in the uterus [7].

Associations of alpha-Methyl-p-tyrosine methyl ester with other chemical compounds

• Apomorphine treatment resulted in a considerable counteraction of the H 44/68 induced reduction of the fluorescence, whereas treatment with haloperidol potentiated it [8].
• D-145 potentiated the depression of CA fluorescence produced by alpha-methyl-tyrosine methyl ester (H 44/68), 250 mg/kg ip [9].

References