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Chemical Compound Review

Felviten     5-(4-methoxyphenyl)dithiole- 3-thione

Synonyms: Sulfogal, Heporal, Mucinol, Sulfarlem, Tiopropen, ...
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Disease relevance of Tiotrifar


High impact information on Tiotrifar


Biological context of Tiotrifar


Anatomical context of Tiotrifar


Associations of Tiotrifar with other chemical compounds


Gene context of Tiotrifar

  • In particular the dithiolthione SULFARLEM, used as anticholestatic drug for more than 40 years, is shown to be antioxidant; preliminary pharmacokinetic data in man are presented, and hepatoprotective and radioprotective effect in mice are demonstrated [13].

Analytical, diagnostic and therapeutic context of Tiotrifar

  • We present our current programme for oral and dental care of xerostomia patients and the results of an open trial with Sulfarlem (trithioparamethoxyphenylpropene) which was found not to be the drug of choice in the treatment of dry mouth associated with SS [3].


  1. Anetholtrithion stabilizes body weight fluctuation caused by excessive water drinking in a patient with schizophrenia: a case report. Matsuo, S., Ninomiya, H., Takasiba, T., Sasaki, Y. The Journal of clinical psychiatry. (1999) [Pubmed]
  2. Effects of chronic anethole trithione and amitriptyline treatment on rat parotid gland signalling. Glenert, U. Eur. J. Pharmacol. (1992) [Pubmed]
  3. Xerostomia due to Sjögren's syndrome. Diagnostic criteria, treatment and outlines for a continuous dental care programme and an open trial with Sulfarlem. Malmström, M.J., Segerberg-Konttinen, M., Tuominen, T.S., Hietanen, J.H., Wolf, J.E., Sane, J.I., Konttinen, Y.T. Scand. J. Rheumatol. (1988) [Pubmed]
  4. Treatment of xerostomia with the bile secretion-stimulating drug anethole trithione: a clinical trial. Hamada, T., Nakane, T., Kimura, T., Arisawa, K., Yoneda, K., Yamamoto, T., Osaki, T. Am. J. Med. Sci. (1999) [Pubmed]
  5. Lens epithelial cell protection by aminothiol WR-1065 and anetholedithiolethione from ionizing radiation. Belkacémi, Y., Rat, P., Piel, G., Christen, M.O., Touboul, E., Warnet, J.M. Int. J. Cancer (2001) [Pubmed]
  6. Inhibition of NF-kappa B activation in human T-cell lines by anetholdithiolthione. Sen, C.K., Traber, K.E., Packer, L. Biochem. Biophys. Res. Commun. (1996) [Pubmed]
  7. HPLC determination of anethole trithione and its application to pharmacokinetics in rabbits. Jing, Q., Shen, Y., Ren, F., Chen, J., Jiang, Z., Peng, B., Leng, Y., Dong, J. Journal of pharmaceutical and biomedical analysis. (2006) [Pubmed]
  8. Treatment of xerostomia in patients with primary Sjögren's syndrome with sulfarlem. Schiødt, M., Oxholm, P., Jacobsen, A. Scand. J. Rheumatol. Suppl. (1986) [Pubmed]
  9. Acute effects of a possible sialogogue, anethole trithione, in rat parotid glands. Glenert, U. Eur. J. Pharmacol. (1991) [Pubmed]
  10. Enhancement of phosphatidylinositol turnover and cyclic nucleotide accumulation by chronic anethole trithione treatment in rat submaxillary glands. Ukai, Y., Taniguchi, N., Yamazaki, A., Kimura, K. J. Pharm. Pharmacol. (1989) [Pubmed]
  11. Enhancement of salivary secretion by chronic anethole trithione treatment. Ukai, Y., Taniguchi, N., Takeshita, K., Ogasawara, T., Kimura, K. Archives internationales de pharmacodynamie et de thérapie. (1988) [Pubmed]
  12. Chronic anethole trithione treatment enhances the salivary secretion and increases the muscarinic acetylcholine receptors in the rat submaxillary gland. Ukai, Y., Taniguchi, N., Takeshita, K., Kimura, K., Enomoto, H. Archives internationales de pharmacodynamie et de thérapie. (1984) [Pubmed]
  13. Sulfur containing compounds as antioxidants. Dansette, P.M., Sassi, A., Deschamps, C., Mansuy, D. Adv. Exp. Med. Biol. (1990) [Pubmed]
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