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Chemical Compound Review

SureCN22885     2-methylamino-3,7- dihydropurin-6-one

Synonyms: SureCN28969, SureCN377762, SureCN377763, AG-D-05000, SureCN8663355, ...
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Disease relevance of Purine analog


Psychiatry related information on Purine analog

  • The purified 2mGII from Tetrahymena is capable of forming both N2-methylguanine and N22-dimethylguanine on a single tRNA isoaccepting species; under conditions of limiting tRNA or long reaction times the predominant product is dimethylguanine [4].

High impact information on Purine analog


Associations of Purine analog with other chemical compounds

  • Electrophoresis in 15% polyacrylamide gels provided evidence for the methylation of precursor tRNA molecules, and high-performance liquid chromatography demonstrated N2-methylguanine to be the predominant methylated base formed during the first 2 min of labelling [7].
  • The methyltransferase which forms N2-methylguanine in the region between the dihydrouridine loop and the acceptor stem (2mG I), when assayed using purified tRNA as substrate, shows high activity with 3--5 mM sperimidine or 20 mM putrescine and significantly lower rates of methylation with 200--350 mM ammonium acetate or 1--10 mM magnesium acetate [8].


  1. Reverse transcriptase pauses at N2-methylguanine during in vitro transcription of Escherichia coli 16S ribosomal RNA. Youvan, D.C., Hearst, J.E. Proc. Natl. Acad. Sci. U.S.A. (1979) [Pubmed]
  2. Interaction of normal and tumor transfer RNA methyltransferases with ethionine-induced methyl-deficient rat liver transfer RNA. Kerr, S.J. Cancer Res. (1975) [Pubmed]
  3. Avian oncornavirus associated N2-methylguanine transferase, location and origin. Pierré, A., Berneman, A., Vedel, M., Robert-Géro, M., Vigier, P. Biochem. Biophys. Res. Commun. (1978) [Pubmed]
  4. A single tRNA (guanine)-methyltransferase from Tetrahymena with both mono- and di-methylating activity. Reinhart, M.P., Lewis, J.M., Leboy, P.S. Nucleic Acids Res. (1986) [Pubmed]
  5. Minor-groove-modified oligonucleotides: synthesis of decadeoxynucleotides containing hypoxanthine, N2-methylguanine and 3-deazaadenine, and their interactions with restriction endonucleases Bgl II, Sau, 3AI, and Mbo I (Nucleosides and Nucleotides Part 75). Ono, A., Ueda, T. Nucleic Acids Res. (1987) [Pubmed]
  6. Transfer RNA methyltransferase activity in paramecium aurelia. Maki, R.A., Brown, J.L., Cummings, D.J. Biochim. Biophys. Acta (1976) [Pubmed]
  7. The postnatal methylation of transfer ribonucleic acid in brain. Evidence for the methylation of precursor transfer ribonucleic acid. Elahi, E., Sellinger, O.Z. Biochem. J. (1979) [Pubmed]
  8. tRNA methyltransferases from rat liver. Differences in response of partially purified enzymes to polyamines and inorganic salts. Leboy, P.S., Glick, J.M. Biochim. Biophys. Acta (1976) [Pubmed]
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