High impact information on Glycyl-L-tyrosine

• The x-ray data to 1.6-A resolution have yielded a well-resolved structure in which the zinc ion of the active site is five-coordinate: three enzyme residues (glutamate-72, histidine-69, and histidine-196) and the carbonyl oxygen and amino terminus of glycyl-L-tyrosine complete the coordination polyhedron of the metal [1].
• In the complex (at 2.0-A resolution) of carboxypeptidase A with the dipeptide glycyl-L-tyrosine, however, the water ligand is replaced by both the carbonyl oxygen and the amino nitrogen of the dipeptide [2].
• Late gestation ovine fetuses of well-nourished ewes received an infusion of Aminosyn PF alone (APF), and Aminosyn PF + glycyl-L-tyrosine (APF+GT) at rates estimated to double the intake of these amino acids [3].
• Tyrosine kinetics and requirements during total parenteral nutrition in the neonatal piglet: the effect of glycyl-L-tyrosine supplementation [4].
• The synthesis and characterization of water-soluble dispersions of gold nanoparticles by the reduction of a potassium tetrabromoaurate precursor solution using the amino acids L-tyrosine, glycyl-L-tyrosine, and L-arginine using alkaline synthesis conditions are reported [5].

Biological context of Glycyl-L-tyrosine

• Results show that exposure of the enzymes to 1-5% (w/v) ethanol caused a dose-dependent inhibition of hydrolysis of L-leucylglycine (Leu-Gly), glycyl-L-tyrosine (Gly-Tyr), and L-phenylalanylglycine (Phe-Gly) by the cytosol peptidases [6].

Anatomical context of Glycyl-L-tyrosine

• Brush-border membrane isolated from hamster jejunum was incubated with L-phenylalanylglycine (Phe-Gly), L-leucylglycine (Leu-Gly), or glycyl-L-tyrosine (Gly-Tyr) in the absence and presence of 1-5% (wt/vol) ethanol, and the L-amino acids liberated were determined [7].

Associations of Glycyl-L-tyrosine with other chemical compounds

• Glycyl-L-glutamine had the longest half-life, glycyl-L-leucine and glycyl-L-tyrosine the shortest half-lives [8].

Analytical, diagnostic and therapeutic context of Glycyl-L-tyrosine

• Voltammetric monitoring of gold nanoparticle formation facilitated by glycyl-L-tyrosine: relation to electronic spectra and transmission electron microscopy images [9].

References