Disease relevance of hydrogen bromide

• Comparisons of the biological data revealed that a chloro or bromo group was required at the 2-position for the best separation of activity against HIV and cytotoxicity [1].
• Another hot tub hazard. Toxicity secondary to bromine and hydrobromic acid exposure [2].
• Dehydration of 2-hydroxy(ethoxy)-2-aryl-N.N-penta(tetra) methylenemorpholinium bromide was achieved either by heating (175 degrees C) the compound with catalytic amounts of hydrobromic acid, or by refluxing the compound in a glacial acetic acid-hydrogen bromide mixture or by treating it with phosphorus tribromide at room temperature [3].
• Salmonella typhimurium tester strains TA1535, TA1530 and TA100, which detect base-pair substitutions in DNA, detected mutagenic degradation products in each of the destruction methods, with the exception of the hydrobromic acid/acetic acid procedure [4].

High impact information on hydrogen bromide

• When a methyl or bromo group was introduced to the C5 position of cytosine, acceleration or suppression of the one-electron oxidation relative to the guanine:cytosine base pair was observed, respectively [5].
• After deprotection of the piperidine nitrogen atom with 48% aqueous hydrobromic acid solution, the title compounds were obtained by three different methods, viz. alkylation, reductive amination, or oxirane ring-opening reactions [6].
• Dealkylation of various aryl alkyl ethers could also be achieved using significantly reduced (i.e., stoichiometric) amounts of concentrated hydrobromic acid (47%) in the ionic liquid [7].
• After reduction by hydrobromic acid and hydrazine sulfate, the inorganic arsenic was extracted into chloroform, back-extracted into 1 mol l-1 HCl, dry-ashed, and quantified by hydride generation-atomic absorption spectrometry (HG-AAS) [8].
• Reaction of 3 with hydrobromic acid afforded the intermediate 1-aryl-5-(bromomethyl)-1H-pyrazoles, which were converted with potassium cyanide to 1-aryl-1H-pyrazole-5- acetonitriles, whose hydrolysis gave the required 1-aryl-1H-pyrazole-5-acetic acids [9].

Biological context of hydrogen bromide

• The development and evaluation of a hydrobromic acid-coated sampling tube for measuring occupational exposures to ethylene oxide [10].
• Bromide and thiocyanate are similar in their catalytic effects on nitrosation, and hydrobromic acid in glacial acetic acid is an effective reagent for denitrosation of nitrosamine [11].

Associations of hydrogen bromide with other chemical compounds

• The direct analysis of 2-bromoethanol by GC/ECD was not reproducible and this effect was attributed to the presence of excess hydrobromic acid (HBr) in the sample [10].

Analytical, diagnostic and therapeutic context of hydrogen bromide

• 2-[18F]Fluoro-L-tyrosine was isolated after full deprotection with aqueous hydrobromic acid and HPLC purification with activities of 1.41 +/- 0.32GBq [12].

References