Disease relevance of Hinosan

• Edifenphos, an organophosphate fungicide, was administered to hemicastrated albino rats intraperitoneally for 15 consecutive days in graded doses of 2 to 8 mg/kg body weight [1].
• Serum transaminases & alkaline phosphatase activities during subacute toxicity of hinosan in Bubalus bubalis [2].
• Effect of edifenphos on compensatory ovarian hypertrophy, follicular kinetics and estrous cycle in hemicastrated rats [1].

High impact information on Hinosan

• The cytogenetic and cytotoxic effects of the pesticides methyl parathion, Bayleton and Hinosan were evaluated in mammalian test systems [3].
• Lipid peroxidation in hepatocytes was stimulated by five pesticides at 10(-3) M, with edifenphos being the most potent peroxidant [4].
• Although treatment with 2 or 4 mg/kg/d edifenphos did not change the number of healthy and atretic follicles, a dosage of 4 mg/kg/d significantly decreased the number and duration of estrous cycles [1].
• A significant decrease in stage I, II, III and total number of healthy follicles, and a significant increase in stage I, III, IV and total number of atretic follicles were observed in 0.3 mg edifenphos treated rats [5].
• Membrane-bound chitin synthase preparations from P. oryzae grown in medium containing 3 or 6 microM-edifenphos had, at the same fungicide concentration, a lower rate of in vivo chitin synthesis than preparations isolated from biomass grown in the absence of edifenphos [6].

Associations of Hinosan with other chemical compounds

• Inhibition of phosphatidylcholine and chitin biosynthesis in Pyricularia oryzae, Botrytis fabae and Fusarium graminearum by edifenphos [6].

Analytical, diagnostic and therapeutic context of Hinosan

• Biochemical changes in liver and plasma of rats after oral administration of edifenphos [7].

References