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Chemical Compound Review

Dexoxadrolum     (2S)-2-[(4R)-2,2-diphenyl- 1,3-dioxolan-4...

Synonyms: AC1MHWRP, SureCN24683, CHEMBL1165411, PDSP1_000674, PDSP2_000664, ...
 
 
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Disease relevance of Dexoxadrol Hydrochloride

 

High impact information on Dexoxadrol Hydrochloride

 

Biological context of Dexoxadrol Hydrochloride

  • Together with dexoxadrol/[3H]PCP competition binding data, which indicated the existence of high and low affinity dexoxadrol/PCP binding sites, these results suggest regional heterogeneity of PCP receptors [7].
 

Anatomical context of Dexoxadrol Hydrochloride

  • Using the dissociative anesthetic dexoxadrol and its inactive isomer levoxadrol as displacing agents, stereospecific binding of 3H-PCP was obtained in rat and pigeon brain membranes [8].
 

Associations of Dexoxadrol Hydrochloride with other chemical compounds

 

Gene context of Dexoxadrol Hydrochloride

  • Structure-affinity relationship studies of non-competitive NMDA receptor antagonists derived from dexoxadrol and etoxadrol [10].
  • Indeed, the conformational analysis of three different chemical families (MK801, PCP, dexoxadrol and their analogues), has allowed us to visualize the different conformations and configurations of each molecule [11].

References

  1. Comparison of the effects of the acute administration of dexoxadrol, levoxadrol, MK-801 and phencyclidine on body temperature in the rat. Pechnick, R.N., Wong, C.A., George, R., Thurkauf, A., Jacobson, A.E., Rice, K.C. Neuropharmacology (1989) [Pubmed]
  2. High efficiency reconstitution of a phencyclidine/MK-801 receptor binding site solubilized from rat forebrain membranes. Haring, R., Pellegrini-Giampietro, D.E., Zukin, S.R., Zukin, R.S., Scheideler, M.A. Mol. Pharmacol. (1991) [Pubmed]
  3. A phencyclidine recognition site is associated with N-methyl-D-aspartate inhibition of carbachol-stimulated phosphoinositide hydrolysis in rat cortical slices. Gonzales, R.A., Moerschbaecher, J.M. Mol. Pharmacol. (1989) [Pubmed]
  4. Analogues of the dioxolanes dexoxadrol and etoxadrol as potential phencyclidine-like agents. Synthesis and structure-activity relationships. Thurkauf, A., Mattson, M.V., Richardson, S., Mirsadeghi, S., Ornstein, P.L., Harrison, E.A., Rice, K.C., Jacobson, A.E., Monn, J.A. J. Med. Chem. (1992) [Pubmed]
  5. Phencyclidine suppresses hippocampal long-term potentiation through stereospecific activation of phencyclidine receptors. Bourne, G.W., Capek, R., Esplin, B. Neuropharmacology (1989) [Pubmed]
  6. Enantiomeric and diastereomeric dioxadrols: behavioral, biochemical and chemical determination of the configuration necessary for phencyclidine-like properties. Jacobson, A.E., Harrison, E.A., Mattson, M.V., Rafferty, M.F., Rice, K.C., Woods, J.H., Winger, G., Solomon, R.E., Lessor, R.A., Silverton, J.V. J. Pharmacol. Exp. Ther. (1987) [Pubmed]
  7. Regional heterogeneity of rat brain phencyclidine (PCP) receptors revealed by photoaffinity labeling with [3H] azido phencyclidine. Haring, R., Kloog, Y., Sokolovsky, M. Biochem. Biophys. Res. Commun. (1985) [Pubmed]
  8. Stereospecific binding of 3H-phencyclidine in brain membranes. Hampton, R.Y., Medzihradsky, F., Woods, J.H., Dahlstrom, P.J. Life Sci. (1982) [Pubmed]
  9. A comparison of PCP-like compounds for NMDA antagonism in two in vivo models. Bennett, D.A., Bernard, P.S., Amrick, C.L. Life Sci. (1988) [Pubmed]
  10. Structure-affinity relationship studies of non-competitive NMDA receptor antagonists derived from dexoxadrol and etoxadrol. Aepkers, M., Wünsch, B. Bioorg. Med. Chem. (2005) [Pubmed]
  11. Molecular modeling of noncompetitive antagonists of the NMDA receptor: proposal of a pharmacophore and a description of the interaction mode. Elhallaoui, M., Laguerre, M., Carpy, A., Ouazzani, F.C. Journal of molecular modeling (Online) (2002) [Pubmed]
 
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