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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

TDGA     2-(carboxymethylsulfanyl) ethanoic acid

Synonyms: PubChem10792, T30007_ALDRICH, USAF E-2, CHEBI:35012, CCG-37662, ...
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Disease relevance of Mercaptodiacetic acid

  • A Gram-negative bacterium, Alcaligenes xylosoxydans ssp. xylosoxydans (SH91), consumed thiodiglycol (TDG), the nontoxic hydrolysis product of sulfur mustard, as a primary carbon source and transformed TDG to commercially relevant chemical precursors, [(2-hydroxyethyl)thio]acetic acid (HETA) and thiodiglycolic acid (TDGA) [1].

High impact information on Mercaptodiacetic acid


Biological context of Mercaptodiacetic acid

  • Since these pre-term infants are exposed to an increased oxygen atmosphere in the incubator, we supposed that these high levels of thiodiacetic acid might be produced from ethylene, generated in the course of lipid peroxidation processes [7].

Associations of Mercaptodiacetic acid with other chemical compounds


Analytical, diagnostic and therapeutic context of Mercaptodiacetic acid


  1. Biocatalytic transformation of [(2-Hydroxyethyl)thio]acetic acid and thiodiglycolic acid from thiodiglycol by Alcaligenes xylosoxydans ssp. xylosoxydans (SH91). Lee, T., Chan, S.H., Weigand, W.A., Bentley, W.E. Biotechnol. Prog. (2000) [Pubmed]
  2. Disposition and metabolism in 1-(2-chloroethyl)-3-(2',3',4'-tri-o-acetyl, ribopyranosyl)-1-nitrosourea in rats. Godeneche, D., Moreau, M.F., Madelmont, J.C., Duprat, J., Plagne, R. Cancer Res. (1982) [Pubmed]
  3. DNA single strand breaks in peripheral lymphocytes associated with urinary thiodiglycolic acid levels in polyvinyl chloride workers. Lei, Y.C., Yang, H.T., Ma, Y.C., Huang, M.F., Chang, W.P., Cheng, T.J. Mutat. Res. (2004) [Pubmed]
  4. Identification of thiodiglycolic acid, thiodiglycolic acid sulfoxide, and (3-carboxymethylthio)lactic acid as major human biotransformation products of S-carboxymethyl-L-cysteine. Hofmann, U., Eichelbaum, M., Seefried, S., Meese, C.O. Drug Metab. Dispos. (1991) [Pubmed]
  5. Synthesis of new chiral sulfinyldiacetic acid derivatives and attempt at chemoselective asymmetric Pummerer reaction. Nagao, Y., Miyamoto, S., Hayashi, K., Mihira, A., Sano, S. Chem. Pharm. Bull. (2002) [Pubmed]
  6. The analysis of thiodiglycollic acid by selected ion monitoring. Pettit, B.R. Clin. Chim. Acta (1986) [Pubmed]
  7. Thiodiacetic acid--a metabolite of Ethylene oxide. Scheick, C., Spiteller, G., Dasenbrock, C. Z. Naturforsch., C, J. Biosci. (1997) [Pubmed]
  8. The biological fate of vinylidene chloride in rats. Jones, B.K., Hathway, D.E. Chem. Biol. Interact. (1978) [Pubmed]
  9. Spectroscopic, redox and biological activities of transition metal complexes with ons donor macrocyclic ligand derived from semicarbazide and thiodiglycolic acid. Chandra, S., Sangeetika, n.u.l.l. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. (2004) [Pubmed]
  10. Determination of thiodiglycolic acid in urine by capillary electrophoresis. Samcová, E., Kvasnicová, V., Urban, J., Jelínek, I., Coufal, P. Journal of chromatography. A. (1999) [Pubmed]
  11. Chromatographic determination of thiodiglycolic acid - a metabolite of vinyl chloride. Dramiński, W., Trojanowska, B. Arch. Toxicol. (1981) [Pubmed]
  12. Identification of S-(carboxymethyl)-L-cysteine and thiodiglycolic acid, urinary metabolites of 2,2'-bis-(chloroethyl)-ether in the rat. Müller, G., Norpoth, K., Eckard, R. Cancer Lett. (1979) [Pubmed]
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