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Chemical Compound Review

Tedegyl     2-(2- hydroxyethylsulfanyl)ethanol

Synonyms: Tiodiglicol, Tiodiglicolo, thiodiglycol, Thiodiethanol, Thiodiglycolum, ...
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Disease relevance of beta-Hydroxyethyl sulfide


High impact information on beta-Hydroxyethyl sulfide


Chemical compound and disease context of beta-Hydroxyethyl sulfide


Biological context of beta-Hydroxyethyl sulfide

  • High resolution product mass spectra were acquired for thiodiglycol, the hydrolysis product of mustard and nine other sulfur containing diols, including five longer chain diols that could not be identified during prior LC-ESI-MS analyses [8].
  • A cutaneous full-thickness liquid sulfur mustard burn model in weanling swine: clinical pathology and urinary excretion of thiodiglycol [9].
  • Stimulation of myogenesis by 2,2'-thiodiethanol in suboptimal tissue culture conditions [10].

Anatomical context of beta-Hydroxyethyl sulfide

  • Supplementation of Eagle's minimal essential medium (EMEM) with Dextran T-500, microelements, Thiodiethanol, and catalase, and incubation of the cultures at 35 degrees C instead at 37 degrees C, provided conditions promoting myotube terminal differentiation to cross-striated myofibres [11].

Associations of beta-Hydroxyethyl sulfide with other chemical compounds


Gene context of beta-Hydroxyethyl sulfide


Analytical, diagnostic and therapeutic context of beta-Hydroxyethyl sulfide

  • Determination of the sulfur mustard hydrolysis product thiodiglycol by microcolumn liquid chromatography coupled on-line with sulfur flame photometric detection using large-volume injections and peak compression [18].
  • This result opens the way for sensitive mass spectrometric detection of sulfur mustard exposure of skin by gas chromatography/mass spectrometry of (derivatized) thiodiglycol [19].
  • This study demonstrates the degradation of thiodiglycol using bioreactors and, more generally, is an experimental study of bioreactor designs for the degradation of growth-inhibitory substances [20].
  • Urine, from human volunteers with no known exposure to sulphur mustard, contained detectable but very low concentrations (<0.2ng/ml) of thiodiglycol, consistent with previous observations using different methodologies [15].


  1. Thiodiglycol, the hydrolysis product of sulfur mustard: analysis of in vitro biotransformation by mammalian alcohol dehydrogenases using nuclear magnetic resonance. Brimfield, A.A., Novak, M.J., Hodgson, E. Toxicol. Appl. Pharmacol. (2006) [Pubmed]
  2. Transformation of thiodiglycol by resting cells of Alcaligenes xylosoxydans PGH10. García-Ruiz, V., Martín-Otero, L.E., Puyet, A. Biotechnol. Prog. (2002) [Pubmed]
  3. Overalkylation of a protein digest with iodoacetamide. Boja, E.S., Fales, H.M. Anal. Chem. (2001) [Pubmed]
  4. 2,2'-Thiodiethanol: A new water soluble mounting medium for high resolution optical microscopy. Staudt, T., Lang, M.C., Medda, R., Engelhardt, J., Hell, S.W. Microsc. Res. Tech. (2007) [Pubmed]
  5. The insulin signal initiating cellular differentiation is preserved by chick embryo myoblasts incubated at 2 degrees C. Reiss, K., Kajstura, J., Korohoda, W. Eur. J. Cell Biol. (1990) [Pubmed]
  6. Quantitation of the sulfur mustard metabolites 1,1'-sulfonylbis[2-(methylthio)ethane] and thiodiglycol in urine using isotope-dilution Gas chromatography-tandem mass spectrometry. Boyer, A.E., Ash, D., Barr, D.B., Young, C.L., Driskell, W.J., Whitehead, R.D., Ospina, M., Preston, K.E., Woolfitt, A.R., Martinez, R.A., Silks, L.A., Barr, J.R. Journal of analytical toxicology. (2004) [Pubmed]
  7. Biocatalytic transformation of [(2-Hydroxyethyl)thio]acetic acid and thiodiglycolic acid from thiodiglycol by Alcaligenes xylosoxydans ssp. xylosoxydans (SH91). Lee, T., Chan, S.H., Weigand, W.A., Bentley, W.E. Biotechnol. Prog. (2000) [Pubmed]
  8. Packed capillary liquid chromatography-electrospray ionization (tandem) mass spectrometry of mustard hydrolysis products in soil. D'Agostino, P.A., Hancock, J.R., Chenier, C.L. Journal of chromatography. A. (2004) [Pubmed]
  9. A cutaneous full-thickness liquid sulfur mustard burn model in weanling swine: clinical pathology and urinary excretion of thiodiglycol. Graham, J.S., Reid, F.M., Smith, J.R., Stotts, R.R., Tucker, E.S., Shumaker, S.M., Niemuth, N.A., Janny, S.J. Journal of applied toxicology : JAT. (2000) [Pubmed]
  10. Stimulation of myogenesis by 2,2'-thiodiethanol in suboptimal tissue culture conditions. Reiss, K., Pietrzykowski, Z., Kajstura, J., Korohoda, W. Folia Histochem. Cytobiol. (1985) [Pubmed]
  11. The formation of myotubes in cultures of chick embryo myogenic cells in serum-free medium is induced by the insulin pulse treatment. Reiss, K., Korohoda, W. Folia Histochem. Cytobiol. (1988) [Pubmed]
  12. Biological fate of sulfur mustard, 1,1'-thiobis(2-chloroethane). Urinary excretion profiles of hydrolysis products and beta-lyase metabolites of sulfur mustard after cutaneous application in rats. Black, R.M., Hambrook, J.L., Howells, D.J., Read, R.W. Journal of analytical toxicology. (1992) [Pubmed]
  13. In vitro oxidation of the hydrolysis product of sulfur mustard, 2,2'-thiobis-ethanol, by mammalian alcohol dehydrogenase. Brimfield, A.A., Zweig, L.M., Novak, M.J., Maxwell, D.M. J. Biochem. Mol. Toxicol. (1998) [Pubmed]
  14. Toxicity assessment of thiodiglycol. Reddy, G., Major, M.A., Leach, G.J. International journal of toxicology. (2005) [Pubmed]
  15. Analysis of the sulphur mustard metabolites thiodiglycol and thiodiglycol sulphoxide in urine using isotope-dilution gas chromatography-ion trap tandem mass spectrometry. Riches, J., Read, R.W., Black, R.M. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. (2007) [Pubmed]
  16. Oxidation of thiodiglycol (2,2'-thiobis-ethanol) by alcohol dehydrogenase: comparison of human isoenzymes. Dudley, B.F., Brimfield, A.A., Winston, G.W. J. Biochem. Mol. Toxicol. (2000) [Pubmed]
  17. Analysis of thiodiglycol in urine of victims of an alleged attack with mustard gas, Part II. Wils, E.R., Hulst, A.G., van Laar, J. Journal of analytical toxicology. (1988) [Pubmed]
  18. Determination of the sulfur mustard hydrolysis product thiodiglycol by microcolumn liquid chromatography coupled on-line with sulfur flame photometric detection using large-volume injections and peak compression. Hooijschuur, E.W., Kientz, C.E., Brinkman, U.A. Journal of chromatography. A. (1999) [Pubmed]
  19. Diagnosis and dosimetry of exposure to sulfur mustard: development of a standard operating procedure for mass spectrometric analysis of haemoglobin adducts: exploratory research on albumin and keratin adducts. Noort, D., Fidder, A., Hulst, A.G., de Jong, L.P., Benschop, H.P. Journal of applied toxicology : JAT. (2000) [Pubmed]
  20. Bioreactor strategies for the treatment of growth-inhibitory waste: an analysis of thiodiglycol degradation, the main hydrolysis product of sulfur mustard. Lee, T., Pham, M.Q., Weigand, W.A., Harvey, S.P., Bentley, W.E. Biotechnol. Prog. (1996) [Pubmed]
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