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Chemical Compound Review

Aminourea     aminourea

Synonyms: Carbazamide, Semikarbazid, Aminomocovina, Semicarbazide, Aminoharnstoff, ...
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Disease relevance of aminourea

  • Here, we present a comparative study between semicarbazide and amine glass slides in an immunofluorescent serodetection assay using HIV (Gp120, Gp41), HCV (mix-HCV, core, NS3, and NS4), and HBV (HBs) recombinant antigens [1].
  • In the recovery studies it was seen that semicarbazide does not allow displacement of all the AcH; treatment of the blood with the reactant sodium nitrite-sulfosalycilic acid and use of the hemolysis method gave levels of recovery lower than 50% [2].
  • Semicarbazide also reduced HCHO-induced cytotoxicity in the Yoshida lymphosarcoma cell line, while no significant alteration in MDMS-induced cytotoxicity was observed [3].
  • The spin-labeled derivative of podophyllotoxin, N'-podophyllic acid-N-[3-(2,2,5,5-tetramethyl pyrrolinenyloxy)] semicarbazide (GP-11), was synthesized and tested for its antitumor activity against mouse transplantable tumors, Sarcoma-180, Hepatoma-A, P388 leukemia and Ehrlich ascites carcinoma [4].
  • Semicarbazide was ineffective against acrolein toxicity [5].

High impact information on aminourea


Chemical compound and disease context of aminourea


Biological context of aminourea


Anatomical context of aminourea


Associations of aminourea with other chemical compounds


Gene context of aminourea


Analytical, diagnostic and therapeutic context of aminourea

  • Lesions of the vPAG did not change the amount of freezing or escape responses produced by microinjections of semicarbazide into the dlPAG [35].
  • We report a novel generation of peptide arrays fabricated by site-specific ligation of glyoxylyl peptides onto glass slides covered by a semicarbazide sol-gel layer [36].
  • Additional data concerning the characterization of the semicarbazide surface (homogeneity of the slides, chemical stability, contact angle measurements, atomic force microscopy studies, reproducibility of serodetection results) are also presented and discussed [1].
  • 5. When intrapulmonary metabolism of phenylethylamine was inhibited by simultaneous perfusion with semicarbazide (10 mM) and pargyline (10 micronM), the removal rate was unaltered, establishing that uptake of the amine from the vascular space is not dependent on metabolism at least for 4 min infusions [37].
  • We describe novel peptide-protein microarrays, which were fabricated using semicarbazide glass slides that permitted the immobilization of glyoxylyl peptides by site-specific ligation and the immobilization of proteins by physisorption [38].


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  22. Tyramine and vanadate synergistically stimulate glucose transport in rat adipocytes by amine oxidase-dependent generation of hydrogen peroxide. Marti, L., Morin, N., Enrique-Tarancon, G., Prevot, D., Lafontan, M., Testar, X., Zorzano, A., Carpéné, C. J. Pharmacol. Exp. Ther. (1998) [Pubmed]
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  36. Peptide arrays for highly sensitive and specific antibody-binding fluorescence assays. Melnyk, O., Duburcq, X., Olivier, C., Urbès, F., Auriault, C., Gras-Masse, H. Bioconjug. Chem. (2002) [Pubmed]
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  38. Peptide-protein microarrays for the simultaneous detection of pathogen infections. Duburcq, X., Olivier, C., Malingue, F., Desmet, R., Bouzidi, A., Zhou, F., Auriault, C., Gras-Masse, H., Melnyk, O. Bioconjug. Chem. (2004) [Pubmed]
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