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Chemical Compound Review

Arphamenine A     5-amino-2-benzyl-8- (diaminomethylideneamin...

Synonyms: AGN-PC-00MCG5, SureCN1782835, NSC-601671, NSC601671, SMP2_000023, ...
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Disease relevance of Arphamenine A


High impact information on Arphamenine A


Anatomical context of Arphamenine A


Associations of Arphamenine A with other chemical compounds

  • Cardiac fibroblasts from passage 2 from normal male adult rats were cultured to confluency and incubated with and without 600 pmol/l TGF-ss1 for 2 days in serum-free Dulbecco's modified Eagle's medium and then incubated with 100 mol/l arphamenine A for 1 day in this medium with added ascorbic acid, ss-aminopropionitrile and titriated proline [6].

Gene context of Arphamenine A


  1. Cell-free biosynthesis of arphamenine A. Okuyama, A., Ohuchi, S., Tanaka, T., Aoyagi, T., Umezawa, H. Biochem. Int. (1986) [Pubmed]
  2. Cloning and characterization of a leucyl aminopeptidase from three pathogenic Leishmania species. Morty, R.E., Morehead, J. J. Biol. Chem. (2002) [Pubmed]
  3. Inhibition of aminopeptidases by peptides containing ketomethylene and hydroxyethylene amide bond replacements. Harbeson, S.L., Rich, D.H. J. Med. Chem. (1989) [Pubmed]
  4. Separation of enkephalin-degrading enzymes from longitudinal muscle layer of bovine small intestine. Enzyme inhibition by arphamenine A. Hazato, T., Shimamura, M., Kase, R., Iijima, M., Katayama, T. Biochem. Pharmacol. (1985) [Pubmed]
  5. Reversal of angiotensin II-stimulated collagen gel contraction in cardiac fibroblasts by aminopeptidase inhibition. Lijnen, P.J., Petrov, V.V., Diaz-Araya, G., Fagard, R.H. J. Cardiovasc. Pharmacol. (2005) [Pubmed]
  6. Collagen production in cardiac fibroblasts during inhibition of aminopeptidase B. Lijnen, P.J., Petrov, V.V., Turner, M., Fagard, R.H. Journal of the renin-angiotensin-aldosterone system : JRAAS. (2005) [Pubmed]
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